cov pid 1 [ . . . . : . . . 80 1 CLN8_Hs 100.0% 100.0% VFWDLAATRAVFGVQSTAAGLWALLGDP---VLHA------------DKARGQQNWCWFHITTATGFFCFENVAVH-LSN 2 Q9QUK3/62-267 100.0% 87.6% VFWNLAATRAVFGVQSTTAGLWALLGDP---VLYA------------DKALGQQNWCWFHITTATGFFFFENVAVH-LSN 3 Q96G23/131-337 97.0% 10.6% KKFREASWRFTFYLIAFIAGMAVIVDKP---WFYDMKKVWEG-----YPIQSTIPSQYWYYMIELSFYWSLLFSIA--SD 4 Q90YY7/131-337 97.0% 14.4% KKFREASWRFTFYLVAFIAGLAALIDKP---WFYDTKEMWAG-----FPVLPLLPSQYWYYMIELGFYMSLLFSVA--SD 5 Q90YY6/137-343 97.0% 13.9% RKFSEASWRFGFYLIIFSAGLISLIHTP---WFWDHRECWSG-----YPAQAVAEAQYWYYIIELSFYLSLLLCVS--VD 6 Q9D6J1/131-337 97.0% 13.9% KKFCEACWRFVFYLCSFVGGTSILYHES---WLWSPSLCWEN-----YPHQTLNLSLYWWYLLELGFYLSLLITLP--FD 7 Q9HA82/131-337 97.0% 14.9% KKFCEASWRFLFYLSSFVGGLSVLYHES---WLWAPVMCWDR-----YPNQTLKPSLYWWYLLELGFYLSLLIRLP--FD 8 Q9D6K9/139-345 97.0% 11.5% TKFCESMWRFTYYLCIFCYGIRFLWSMP---WFWDTRQCWYN-----YPYQPLSRELYYYYITQLAFYWSLMFSQF--ID 9 AAL89720/131-33 97.0% 10.6% TKFCESMWRFTFYLYIFCYGIRFLWSTT---WFWDTRQCWYN-----YPYQPLTSGLYYYYIKELAFYWSLMFSQF--TD 10 Q95RN6/134-339 96.5% 11.1% VKFCENTWRCIYYLYSFIFGVIVLWDKP---WFWDVKSCWYG-----YPHQSISNDIWWYYMISMSFYWSLTGTQF--FD 11 Q9GYR9/90-308 97.0% 9.1% KKILECFWRFSYYTFAFLYGLYVMKNSS---WLYDVKQCWIG-----YPFHPVPDTIWWYYMIETGFYYSLLIGST--FD 12 Q21158/171-388 98.5% 11.6% SRMAECAMRALYYTISFVCGLYLVLHES---HLYDITECWRN-----WPFHPIPNAVAWYYWIQGGFYIALVFGIL-FLD 13 Q9LDF2/76-294 98.5% 12.0% RKFKESAWKCIYYLSAELLALSVTYNEP---WFSNTLYFWIGPGDQIWPDQPMKMKLKFLYMFAAGFYTYSIFALV-FWE 14 Q9FZ69/73-292 98.5% 11.5% RKFKESAWKCVYYLSAEILALSVTYNEP---WFMNTKYFWVGPGDQTWPDQQTKLKLKLLYMFVAGFYTYSIFALV-FWE 15 Q8W4Y5/72-289 97.5% 9.6% RKFKESAWKCIYFLSAEVFALVVTYNEP---WFTNTRYFWVGPGDQVWPDQMYKSKLKALYMYTGGFYTYSIFALI-FWE 16 Q9M6A4/73-292 98.0% 11.4% NKFKESAWKFVYFLSAELLALSVTCNEP---WFTDSRYFWAGPGDVVWPNLKMKLKLKLLYMYAGGFYFYSIFATL-YWE 17 Q9M6A2/71-283 98.5% 8.1% VKCKESLWKLLYYAACDFFVLQVIYHEP---WARDIKLYFHG-----WPNQELKLSIKLYYMCQCGFYVYGVAALL-AWE 18 YHXF_SCHPO/144- 98.0% 10.1% RRFEEQAYTCLYFTVMGSWGLYVMKQTPM--WFFNTDAFWEE-----YPHFYHVGSFKAFYLIEAAYWIQQALVLILQLE 19 LAG1_YEAST/171- 98.0% 11.5% KRMLEQMYAIFYCGVSGPFGLYIMYHSDL--WLFKTKPMYRT-----YPVITNPFLFKIFYLGQAAFWAQQACVLVLQLE 20 Q9GVA0/92-298 97.0% 11.1% TKFKETSWRFLAYSCLVGCGMWGTVKEP---FFWDQSLCFYG-----YPSTPPSNAVLSYWAFQLAFYSSLLVSQF--SD 21 Q9Y1V7/133-338 95.5% 10.0% TKFQETFWRFAFYLTSFFYGLYVMYDQEC---VWQTEKCFSN----YPEDHVLSQKIYYYYLIELAFYSATTLTQF--FD 22 LAG1_SCHPO/153- 98.0% 8.8% IRFCEQGYSFFYYLCFWFLGLYIYRSSN---YWSNEEKLFED-----YPQYYMSPLFKAYYLIQLGFWLQQILVLH-LEQ 23 LSS1_HUMAN/97-3 98.0% 10.0% AKMPESAWKFLFYLGSWSYSAYLLFGTDYP-FFHDPPSVFYDW----TPGMAVPRDIAAAYLLQGSFYGHSIYATL-YMD 24 CAD26440/65-270 96.0% 11.0% KKFCISLWKAMFYSFTSVYGYFVIRSEP---RAYTAKNLMDT-----WGVHGAPSKVLFFYHLEFSYYFVELFYLF--SE 25 Q9XWE9/102-326 98.5% 7.2% HKVPESFWKLTYYGTVWIFAFYFHMCVDSHDIFNDPLSMWIEWE--SGGRPKMHWQVQVIYAVQSAFYIHSIYATL-FMD 26 AAH24829/116-32 97.5% 11.2% NKLNEAGQLSVFYIVSGIWGMIILASEN---CLSDPTLLWKS-----QPHNMMTFQMKFFYISQLAYWFHSFPELY-FQK 27 Q90ZM0/116-328 97.5% 6.5% SKFNESGQLSAFYLFSCIWGASIIVSEN---YFSDPISLWKG-----YPHTYFPFQMKFFYISQLAYWFHAFPELY-FQK 28 Q90ZM1/117-329 97.5% 8.8% SKFNESGQLSAFYLFSCLWGASILGSEN---ILSNPVSLWDG-----YPHTLMQFQMKFYYICQLGYWLHAIPELY-FQK 29 Q90ZL9/111-323 97.5% 8.4% SRFNESGQLAAFHLASMFWCLYVSATEG---YLSYPKTLWES-----YPHVYLPFQVKFFYLCQLAYWLHALPELY-FQK 30 Q924Z5/112-324 97.5% 7.4% SKFNESGQLLVFHLSAVAWCFYVIVTEG---YLTNPRSLWED-----YPHVYLSFQVKFFYLGQLAYWLHSLPELY-FQK 31 Q9XXK7/123-342 97.0% 8.1% FKFGESFHQMFFTVYSIAHAFYIVSERLEDFSEVKSFSVWLGY---PTEHRVMSAAYKLYFIFQISYWIHQFPEFY-LQK 32 Q9W5C3/1330-153 94.0% 8.9% QLVAFYLLSFVWGAHVLLKEGYLGQVAQ-----LWEG----------FPDHPMSFLHKFYFVVQLAYYLHMLPELY-FQK 33 Q9V3S7/127-403 98.5% 10.2% SDVLEITNKIVSAIQASFSFFVGLIVCKS---TCTKSFVYASHF--LMEAYGWFGTAYFMYDIWSMYKVHTQKIADKLHL 34 Q9XHZ7/65-275 95.5% 12.1% SRDPIFVNTSVSLLHSIITSASVVFILL---NQCLAKGLDEMFDH-SELVGGTWKWAYPALCFSCGYFAYDQWDML-QYR 35 Q93892/84-290 94.5% 11.3% IKRKRLLNLTTSLIHSTISGLYLFAFFC-----YNTKLMFA------APLHYYTYLDSQIITLSIGYFFYDGIDLVMNDK 36 Q20297/56-260 94.5% 12.3% FKRYRLQNLTVCWLHAVIVGGGDLILMF-----SHPHEIF------HDVIDWYNPIAAQLPLISVAYFFQDAFDMLMYEW 37 Q99JT6/40-239 93.0% 13.4% LRTWRWHNLLVSFTHSIVSGIWALLCLWQ---TPEMLV---------EIETAWSASGYLLVCFSAGYFIHDTVDIVVSKQ 38 Q9N5G9/75-277 94.5% 13.9% LKKWRISNESVSMVHSAISGFWAAYALI----VDPELFK--------SPILYHCIVGRNLVLMMTGYLLNDLVDLICNER 39 Q9XTE6/102-304 94.5% 12.4% NKKWRISNECVSLFHSVISGLWAAYALL----YYKQLVQ--------DLVNYRCDVAINLVLMSAGYLFHDLVDLLVNEQ 40 Q9BL09/35-249 96.5% 14.0% NKTRLFAVRVVSFTHALVSALGCIFSLL-----TDVNYVR-------EPYDYHKANAEYVFLFSMGYFIYDLLDMHIHGE 41 15862410/29-230 94.5% 9.6% HRSYEWSCRLVTFTHGVLSIGLSAYIGFID-GPWPFT----------HPGSPNTPLQVHVLCLTLGYFIFDLGWCVYFQS 42 Q9LI49/25-219 91.0% 12.5% KRSYDFCNRAVSAAHAAAAVSLACLSVA---DWSRPLS---------PLAAASSPPQMKALAVTLSYMVYDAACCYLNDD 43 Q9P3N6/69-308 95.5% 14.8% SKKANWDTHVVSLVQSTLINVLALWVMY----ADKERAAMDWE----QRIWGYTGASGMIQALACGYFVWDLGITLLNFD 44 O13752/74-276 93.5% 13.7% KTRLNWDAHVVSSVQSIVLICLGYTCL-------KEVNAFP------DKLFGYSVVAGDIYALTAGYFVWDLYITVRYVH 45 YJ86_YEAST/70-2 95.0% 12.7% LLKIDFNVHTVSMIQAVVSNTVLLPTL------TTPMHY--------NVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFK 46 Q06107/95-307 95.0% 13.3% SLINQSSVHLISLLQSIVVLYYSLKFLLDP-KASAEPYQTS-----HSRVFTENRDTQVICIFAIGYFVWDIYISTMYS- 47 Q8VZR3/32-226 91.0% 13.9% SYSFSFSNRLLSTAHATIAVTLATLSVQ---DLSCPVC---------PLASKPSHKQMDVMAFSLSYMIYDLICCHFDQV 48 Q96MV1/44-251 96.0% 14.7% KKKIEWNSRVVSTCHSLVVGIFGLYIFL-----FDEATKA-------DPLWGGPSLANVNIAIASGYLISDLSIIILYWK 49 Q93Z82/69-278 95.0% 11.6% IQRIEWNNRGISTVHAIFISAMSLYFVF----WSDLFSDRWHN---DLVVFRSSRLSSLGLGISIGYFLADLGMIFWKYP 50 Q93ZA9/52-261 95.5% 13.1% KVRMEWNNRGFSTFHAVFTSVASIYFLV----ISDQFDENVHG---DSVINSTTRLSESVMGISLGYFLADLAMIFWYFP 51 Q93VP0/48-253 95.5% 14.8% MKKVEWNNRGFSTFHALVAAVVSFYLVV----ISDLFHS-------NIIIDRNSWLSDAMFGVSIGYFLTDLVMILWYFP 52 Q8VC26/33-231 92.5% 13.4% RDRWMWRNIFVSLIHSLLSGVGALVGLW----QFPQMVT--------DPINDHPPWARVLVAVSVGYFAADGVDMLWNQT 53 Q9LYA1/356-566 96.0% 9.8% QIRPEASSCLISIFHGSPAVFLATRAVFS-----SSER---------SFASANTAAQNTVLDFSVAYFLTDLFHYIVFNP 54 Q9LK26/35-246 97.5% 11.3% ETRPLASSCLISLLHGVSAVVLATNALLS-----DPNR---------GFSSVNTQSQNSILDFSSAYFLADLVHLAVFPS 55 Q9LU96/39-250 97.5% 9.4% QSSHLGASCLMSLFHGTPAVIMASHALLT--TPRADVH---------SFASPNTAVESNVLDFSMAYFTVDLLHYLIFLP 56 Q9CW26/66-297 97.5% 13.8% ADAVIVSARLVSSVQAIMASTAGYIVST----SCK------------HIIDDQHWLSSAYTQFAVPYFIYDIYAMFLCHW 57 ENSG00000083426 99.0% 12.3% TDCVMISTRLVSSVHAVLATGSGIVIIR----SCD------------DVITGRHWLAREYVWFLIPYMIYDSYAMYLCEW consensus/100% ..................................................................ah............ consensus/90% ..h.....hhh.hh.....sh..hh..................................hh.hthuahh..h...h.... consensus/80% .ph.p...phh.hh.uhhhshhhhh.........p........................hhhhthuaah..hh.hh...p consensus/70% p+hhc.s.phh.hhpuhhhuhhshht......h.s.h.h..........hthhs..hhhhhhhphuaahhphhthh...p cov pid 81 . 1 . . . . : . 160 1 CLN8_Hs 100.0% 100.0% LIFRTF----------------------------------------------------------DLFLVIHHLFAFLGFL 2 Q9QUK3/62-267 100.0% 87.6% LFFRTF----------------------------------------------------------DLFLVVHHLFAFLGFL 3 Q96G23/131-337 97.0% 10.6% VKRKD-----------------------------------------------------------FKEQIIHHVATIILIS 4 Q90YY7/131-337 97.0% 14.4% VKRKD-----------------------------------------------------------FKEQIVHHVATILLIS 5 Q90YY6/137-343 97.0% 13.9% IKRKD-----------------------------------------------------------FQEQIIHHIATIFLIA 6 Q9D6J1/131-337 97.0% 13.9% VKRKD-----------------------------------------------------------FKEQVVHHFVAVGLIG 7 Q9HA82/131-337 97.0% 14.9% VKRKD-----------------------------------------------------------FKEQVIHHFVAVILMT 8 Q9D6K9/139-345 97.0% 11.5% VKRKD-----------------------------------------------------------FLMMFIHHMIGIMLTT 9 AAL89720/131-33 97.0% 10.6% IKRKD-----------------------------------------------------------FLIMFIHHLATVGLIS 10 Q95RN6/134-339 96.5% 11.1% VKRKD-----------------------------------------------------------FWQMFIHHMVTLLLMS 11 Q9GYR9/90-308 97.0% 9.1% VRRSD-----------------------------------------------------------FWQLMVHHVITIFLLS 12 Q21158/171-388 98.5% 11.6% AKRSD-----------------------------------------------------------FWQMLVHHFITLALIG 13 Q9LDF2/76-294 98.5% 12.0% TRRSD-----------------------------------------------------------FGVSMGHHITTLVLIV 14 Q9FZ69/73-292 98.5% 11.5% TRRSD-----------------------------------------------------------FGVSMGHHIATLILIV 15 Q8W4Y5/72-289 97.5% 9.6% TRRSD-----------------------------------------------------------FGVSMSHHVATAILIV 16 Q9M6A4/73-292 98.0% 11.4% TRRYD-----------------------------------------------------------FAAQIIHHVTTVSLIV 17 Q9M6A2/71-283 98.5% 8.1% TRRKD-----------------------------------------------------------FAVMMSHHVITIILLS 18 YHXF_SCHPO/144- 98.0% 10.1% KPRKD-----------------------------------------------------------FKELVVHHIITLLLIG 19 LAG1_YEAST/171- 98.0% 11.5% KPRKD-----------------------------------------------------------YKELVFHHIVTLLLIW 20 Q9GVA0/92-298 97.0% 11.1% IRRKD-----------------------------------------------------------FYQMCVHHIVTIALLM 21 Q9Y1V7/133-338 95.5% 10.0% VKRKD-----------------------------------------------------------FWEMFIHHIVTIILLC 22 LAG1_SCHPO/153- 98.0% 8.8% RRAD------------------------------------------------------------HWQMFAHHIVTCALII 23 LSS1_HUMAN/97-3 98.0% 10.0% TWRKD-----------------------------------------------------------SVVMLLHHVVTLILIV 24 CAD26440/65-270 96.0% 11.0% HAYKD-----------------------------------------------------------FLQMVTHHIVTMLLLF 25 Q9XWE9/102-326 98.5% 7.2% LWRKD-----------------------------------------------------------SWLMFVHHFIALGLLF 26 AAH24829/116-32 97.5% 11.2% VRKQD-----------------------------------------------------------IPGQLIYIGLHLFHIG 27 Q90ZM0/116-328 97.5% 6.5% TKKED-----------------------------------------------------------IPRQLVYIGLYLFHII 28 Q90ZM1/117-329 97.5% 8.8% AKKED-----------------------------------------------------------IPRQLVYISLYLVHIA 29 Q90ZL9/111-323 97.5% 8.4% VKKEE-----------------------------------------------------------VPRQLQYIVLYLLHIA 30 Q924Z5/112-324 97.5% 7.4% VRKEE-----------------------------------------------------------VPRQLQYICLYLLHIT 31 Q9XXK7/123-342 97.0% 8.1% LKRDE-----------------------------------------------------------IRQKSVQAILHIAFIS 32 Q9W5C3/1330-153 94.0% 8.9% IKTKEE----------------------------------------------------------QQPKIVHSISGFTLIV 33 Q9V3S7/127-403 98.5% 10.2% LRITKGQGAVVSNGHANGKVNGKSASGNNNGSTPTNLHEICDYDGACVQIPKDGRWDFLKYVVTHPVMMIHHVFIGTFGL 34 Q9XHZ7/65-275 95.5% 12.1% LYSGL-----------------------------------------------------------IPSILVHHLVLLVCFT 35 Q93892/84-290 94.5% 11.3% LSIS------------------------------------------------------------TGVLLFHHVASIYVLS 36 Q20297/56-260 94.5% 12.3% NSY-------------------------------------------------------------TLELLLHHFATCAALV 37 Q99JT6/40-239 93.0% 13.4% TRA-------------------------------------------------------------SWEYLVHHVMAMGAFF 38 Q9N5G9/75-277 94.5% 13.9% SVR-------------------------------------------------------------IVELLFHHVVVLSAFT 39 Q9XTE6/102-304 94.5% 12.4% SAR-------------------------------------------------------------IIELLFHHVVVLSAFA 40 Q9BL09/35-249 96.5% 14.0% LES-------------------------------------------------------------SKEYLIHHSLVITAFS 41 15862410/29-230 94.5% 9.6% E---------------------------------------------------------------GALMLAHHTLSILGII 42 Q9LI49/25-219 91.0% 12.5% V---------------------------------------------------------------RVDNTVHHLVSIVGIA 43 Q9P3N6/69-308 95.5% 14.8% IF--------------------------------------------------------------GFGLLAHAVSALVVYS 44 O13752/74-276 93.5% 13.7% IT--------------------------------------------------------------GIGFVIHAIAALFVIT 45 YJ86_YEAST/70-2 95.0% 12.7% LY--------------------------------------------------------------GLEFTGHAIGSVYVML 46 Q06107/95-307 95.0% 13.3% ----------------------------------------------------------------TFPFVVHGIISTVVFC 47 Q8VZR3/32-226 91.0% 13.9% F---------------------------------------------------------------SIDNAVHHFVSILGFI 48 Q96MV1/44-251 96.0% 14.7% VIG-------------------------------------------------------------DKFFIMHHCASLYAYY 49 Q93Z82/69-278 95.0% 11.6% SLG-------------------------------------------------------------GIEYIVHHSLSGVAVA 50 Q93ZA9/52-261 95.5% 13.1% TLG-------------------------------------------------------------GIEYVFHHFLSMFAII 51 Q93VP0/48-253 95.5% 14.8% SLG-------------------------------------------------------------GKEYLLHHGLSMYAIC 52 Q8VC26/33-231 92.5% 13.4% LAQ-------------------------------------------------------------AWDLLCHHLAVVSCLS 53 Q9LYA1/356-566 96.0% 9.8% N---------------------------------------------------------------DVLFIGHHVATLFVFL 54 Q9LK26/35-246 97.5% 11.3% PAGG------------------------------------------------------------DSLFAAHHLAVLFVFL 55 Q9LU96/39-250 97.5% 9.4% N---------------------------------------------------------------DFIFILHHIATLYVFA 56 Q9CW26/66-297 97.5% 13.8% HKHQVKGHG---------------------------------GEDGTPRALGSTWAVVRGYLHKEFLMVLHHAAMVLVCF 57 ENSG00000083426 99.0% 12.3% CRTRDQNR--------------------------------------------APSLTLRNFLSRNRLMITHHAVILFVLV consensus/100% ...........................................................................h.hh. consensus/90% ....................................................................hhathh.hhhh. consensus/80% hh...............................................................h..hhHHhhshhhhh consensus/70% hht.............................................................hh.hhhHHhhslhhhh cov pid 161 . . . 2 . . . . 240 1 CLN8_Hs 100.0% 100.0% GCLVNLQAGHYLAM--TTLLLEMSTPFTCVSWMLLKAG----------WSESLFWKLNQWLMIHMFHCRMVLTYHMWWVC 2 Q9QUK3/62-267 100.0% 87.6% GSAINLRAGHYLAM--TTLLLEMSTPFTCISWMLLKAG----------WSDSLFWKANQWLMIHMFHCRMILTYHMWWVC 3 Q96G23/131-337 97.0% 10.6% FSWFANYIRAGTL---IMALHDSSDYLLESAKMFNYAG-----------WKNTCNNIFIVFAIVFIITRLVILPFWILHC 4 Q90YY7/131-337 97.0% 14.4% FSWCVNYIRAGTL---IMLVHDASDYLLESAKMFNYAG-----------WRKTCNYIFIIFAAIFIITRLVIFPFWILHC 5 Q90YY6/137-343 97.0% 13.9% FSYCANYVRVGTL---VMLVHDSSDFLLESAKMFNYAG-----------WRKTCDALFVVFAAVFLVTRLIVFPFRIVYT 6 Q9D6J1/131-337 97.0% 13.9% FSYSVNLLRIGAV---VLLLHDCSDYLLEGCKILNYAH-----------FRRGCDALFIMFALVFFYTRLIFFPTQVIYT 7 Q9HA82/131-337 97.0% 14.9% FSYSANLLRIGSL---VLLLHDSSDYLLEACKMVNYMQ-----------YQQVCDALFLIFSFVFFYTRLVLFPTQILYT 8 Q9D6K9/139-345 97.0% 11.5% FSYVNNMVRVGAL---IFCLHDFADPLLEAAKMANYAR-----------RERLCTTLFVIFGAAFIVSRLAIFPLWILNT 9 AAL89720/131-33 97.0% 10.6% FSYVNNMVRVGTL---VMCLHDASDFLLEAAKLTNYAK-----------FQRLCDSFFMFFALVFVTTRLIIFPLWILNT 10 Q95RN6/134-339 96.5% 11.1% LSWVCNLHRVGSL---VLVVHDCADIFLEAAKLTKYAK-----------YQKLCDAIFAIFTVVWIVTRLGFYPRIIYSS 11 Q9GYR9/90-308 97.0% 9.1% SSWTINFVRVGTL---ILLSHDVSDVFLEGGKLVRYDAHNK----------NMTNFMFVLFFSSWVATRLIYYPFIVIRS 12 Q21158/171-388 98.5% 11.6% VSWTMNMVRVGTL---ILVSHDAVDILIDVGKILRYEQ-----------FETALTICFAGVLFVWVATRLVYYPFWIIRS 13 Q9LDF2/76-294 98.5% 12.0% LSYICRLTRAGSV---ILALHDASDVFLEIGKMSKYCG-----------AESLASISFVLFALSWVVLRLIYYPFWILWS 14 Q9FZ69/73-292 98.5% 11.5% LSYVCSFSRVGSV---VLALHDASDVFLEVGKMSKYSG-----------AERIASFSFILFVLSWIILRLIYYPFWILWS 15 Q8W4Y5/72-289 97.5% 9.6% LSYNIRFARVGSV---VLAIHDASDIFLEIGKMSKYSG-------------AEALASFRYLCLSWIILRLIYYPFWVLWS 16 Q9M6A4/73-292 98.0% 11.4% LSYVYGFARIGSV---VLALHDGSDVFMEIAKMSKYSG-----------FDLIADIFFSLFALVFTSLRIICYPFWIIRS 17 Q9M6A2/71-283 98.5% 8.1% YSYLTSFFRIGAI---ILALHDASDVFMETAKIFKYSE-----------KEFGASVCFALFAVSWLLLRLIYFPFWIIRA 18 YHXF_SCHPO/144- 98.0% 10.1% LSYYFHFTWIGLA---VFITMDTSDIWLALSKCLNYVN------------TVIVYPIFVIFVFVWIYMRHYLNFKIMWAV 19 LAG1_YEAST/171- 98.0% 11.5% SSYVFHFTKMGLA---IYITMDVSDFFLSLSKTLNYLN------------SVFTPFVFGLFVFFWIYLRHVVNIRILWSV 20 Q9GVA0/92-298 97.0% 11.1% FAYTVNMFQIGVL---IALVHDFSDVPLELAKLLHYAS-----------YEGLAQASFVVFSIVFVLTRLIVYPFWLIWS 21 Q9Y1V7/133-338 95.5% 10.0% GSYTLNYTKMGAF---ILVVHDSADFYIEFAKMGKYAN-----------NSLVTNVGFISFTISFFLSRLVILPLWIVPS 22 LAG1_SCHPO/153- 98.0% 8.8% LSYGFNFLRVGNA---ILYIFDLSDYILSGGKMLKYLG-----------FGKICDYLFGIFVASWVYSRHYLFSKILRVV 23 LSS1_HUMAN/97-3 98.0% 10.0% SSYAFRYHNVGIL---VLFLHDISDVQLEFTKLNIYFKSRGGS--YHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYA 24 CAD26440/65-270 96.0% 11.0% LSYHNDLLRAGVA---IIVIHDISDPFLEIGKLTNYIH-----------DKSLATSIFTCFAGIFIASRLGIYAFLLSLP 25 Q9XWE9/102-326 98.5% 7.2% LSYVDNFTLPGAL---VLFLHDNSDATLEITKLSFYLKKRTNRQ-YYKYYFLMGNAAFILFAIIWVIFRLYWYTCKLLYA 26 AAH24829/116-32 97.5% 11.2% GAYLLYLNHLGLL---LLMLHYAVELLSSVCSLLYFGD-------------ERYQKGLSLWPIVFISGRLVTLIVSVVTV 27 Q90ZM0/116-328 97.5% 6.5% GAYVLNLNRLGLV---LLVLHYFVEFLFHMSRLFYFSN-------------ERYQKGFTVWAVLFVLGRLLTLILSVLTV 28 Q90ZM1/117-329 97.5% 8.8% GAYALNLNRLGLV---LLVLHYFVELIFHVSRLIYFSN-------------EERQSGFTVWAVLFVLGRLLTLSLSVLTV 29 Q90ZL9/111-323 97.5% 8.4% GAYLLNLTRLGLI---LLLLQSVAEFLFHIARLFYFTD-------------ENNQRLFNAWGVVFVITRLFTLTLSVLTI 30 Q924Z5/112-324 97.5% 7.4% GAYLLNLSRLGLI---LLLLQYSTEALFHMARLFHFAD-------------ENNERLFNAWAAVFGVTRLFILTLAVLTI 31 Q9XXK7/123-342 97.0% 8.1% IAYFFNFTRVGLA---LITLEYITQLIFHIARFAHFVGRKG-----------LSDPAFKLFNGSFVLVRLGSIIIAVMTF 32 Q9W5C3/1330-153 94.0% 8.9% LAYTLSFQRLALV---LLTLHYFSELLSHVFQLIGVFD-----------REERLAKLRVVNNAVFFLIRFATSVIGVLTL 33 Q9V3S7/127-403 98.5% 10.2% LVVTYIRGGGHCIYS-YMFMMEFSTPFVSLRSILSTMRLKD---------SRVYIANGLLMLATFFVCRVCMWPYVMWRY 34 Q9XHZ7/65-275 95.5% 12.1% LALYRNVTINYLI---LTLICEMHSIFLHVRKLRRMAGIRD-------SNTALVKLEWVLNWTAFVFARCIPHILITIKL 35 Q93892/84-290 94.5% 11.3% TAVLSKKFLLYAY---WAMLMEVSSIFLHTRSILHISKLSTTS------MIGFSKVVSYLNLITFIVFRGFVQFFLFGWA 36 Q20297/56-260 94.5% 12.3% APGLTGKFTLAAG---WALLMEVNSIFLHARTILQICGLST-------QFPGVFRVVVYSNIISFFFFRIVSQILWTNWA 37 Q99JT6/40-239 93.0% 13.4% SGIFWKRFVGGGV---LTLLVEVSNIFLTLRMMMKINNAQD---------LLLYKVNKYINLVMYFLFRLAPQAYLTKFF 38 Q9N5G9/75-277 94.5% 13.9% ICLFYDLMLGIVV---AGLLMELNSIFLHIRSLMNLYGFDK--------KLTAFRVTVILNIITLVVFRLIVNVYMIYFV 39 Q9XTE6/102-304 94.5% 12.4% VTMFFNRFLGVVV---FGLLMELNSIFLHSRSLLNLYGVDK--------KSPSFRIIALLNMVTLFAFRLCVSAYLVYFV 40 Q9BL09/35-249 96.5% 14.0% IILLSGRLFGLAM---IALLVEIQTVFLHLRTMVRLLYGSKH-------MPASIDVLINANMICLFLFRHLPVCYLLFYL 41 15862410/29-230 94.5% 9.6% XALVLGESGTEVNA--VLFGSELTNPLLQMRWFLRETG---------HYHSFTGDVVDFLFVALFTGVRIGVGACLLFCE 42 Q9LI49/25-219 91.0% 12.5% AGLAYRRCGTEMVA--SLFVTEISSPLLHLREILKEFGIKD---------TDLNLLVDILFAVIFSVARMGFGPYLTYVT 43 Q9P3N6/69-308 95.5% 14.8% FGFRPFLNYYSTT----FILYELSTPFLNIHWFFDKLNMTG---------SRAQLYNGIALLVTFFGCRLIWGTWQSIEV 44 O13752/74-276 93.5% 13.7% FSYRPYLMYYGPT----YLSWELSTPFLNIHYFLDKTNRTG---------SKFQMINGFILIVTFICVRIAWGWFSAYST 45 YJ86_YEAST/70-2 95.0% 12.7% LSLRPFCQPWIGR----FLIYEASTPFVNINWFIMQCNAKSKN----SIPLWFNVVNGLLLMTVFFVVRICWGSIASALL 46 Q06107/95-307 95.0% 13.3% IGLKPYIQYYAPV----FLMFELSNPSLNFRWFGIKFLPQKSKF-----CSLLLLLNNLTLMVVFFAARIAWGWFQIGKL 47 Q8VZR3/32-226 91.0% 13.9% AGLAYQKSGSEIVA--TLWVAEISSPFFHLREILKEIGYKD---------TKLNLAADVCFATIFTLARIVCGPFLVYVS 48 Q96MV1/44-251 96.0% 14.7% LVLKNGVLAYIGN---FRLLAELSSPFVNQRWFFEALKYPK--------FSKAIVINGILMTVVFFIVRIASMLPHYGFM 49 Q93Z82/69-278 95.0% 11.6% YSLFSGEGQLYTY---MVLISEITTPEINLRWYLDTAGMKK---------SLAYVVNGVFIFLAWLVARILLFIYMFYHV 50 Q93ZA9/52-261 95.5% 13.1% LSVTSGQSQFYIF---LVLLSEATTPFVNLRWYLDNSGQKG---------SKAYTLNGIALFLGWLVARVLLFIFFFVHM 51 Q93VP0/48-253 95.5% 14.8% LALLSGKAHMYIL---MVLFTEATTPFVNLRWYLEVAGKKT---------HNLYLYNGLALFVGWLVARVILFIYFFTHM 52 Q8VC26/33-231 92.5% 13.4% TAVVSGHYVGFSM---VSLLLELNSICLHLRKLLLLSHKAP---------SLAFRVSSWASLATLVLFRLLPLGWMSLWL 53 Q9LYA1/356-566 96.0% 9.8% TCRFLVFHGACAIL-GLLILAEVTSACQNAWTLAGARKNDP----ESRLAVKVYDLLSPPFYAFYSIVRGVLGPLFFGKM 54 Q9LK26/35-246 97.5% 11.3% TCRYMVAHGACALL-ALLVVAEATSACQNTWTLADARGKDA------PLAVSLHRFVTVPFYASYSVCRCVLAPLLIVKM 55 Q9LU96/39-250 97.5% 9.4% TCRFAVGHGAHGLL-LLLILAEATSACQNVWTITGYRKNDV------ALARRVRELLSPPFYLFYTVVRGLAGPVVLYDM 56 Q9CW26/66-297 97.5% 13.8% PLSVVWRQGKGDFFLGCMLMAEVSTPFVCLGKILIQYKQQH---------TLLHKVNGALMLLSFLCCRVLLFPTCTGPT 57 ENSG00000083426 99.0% 12.3% PVAQRLRGDLGDFFVGCIFTAELSTPFVSLGRVLIQACMNEMTESLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSY consensus/100% ..................h.....p...t...h...............................h...Rhh......... consensus/90% .shh..h..hh.h...hhhh...sp.hhpht.h....t.......................hh.hhhhRhh...h.hh.. consensus/80% hshh..h.hhh.h...hhhlh-hss.hhphthhh.h.t..............hh.h.hhhhhh.ahhhRhhhh.hhhhh. consensus/70% huhhhthhthssh...hhhlt-hos.hlphtphhphht............tthhph.hhhhhhsahhsRlhhhshhhhhh cov pid 241 : . . . . 3 . ] 318 1 CLN8_Hs 100.0% 100.0% FWHWDGLVSSL-------------------------------YLPHLTLFLVGLALLTLIINPYWTHKKTQQLLNPVD 2 Q9QUK3/62-267 100.0% 87.6% FCHWDALTSSL-------------------------------HLPHWALFLFGLALLTAVINPYWTHKKTQQLLHPVD 3 Q96G23/131-337 97.0% 10.6% TLVYPLELYPA---------------------------------FFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFIT 4 Q90YY7/131-337 97.0% 14.4% TWVYPVTVYPP---------------------------------FFGYYFFNGLLFVLQCLHIFWAVLILRMAIKFLP 5 Q90YY6/137-343 97.0% 13.9% AVVDSLIVFSP---------------------------------YPGYYFFNGLLLVLQALHIFWAWLILRMVHKFVF 6 Q9D6J1/131-337 97.0% 13.9% SVYDSIKNSGP---------------------------------FFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLH 7 Q9HA82/131-337 97.0% 14.9% TYYESISNRGP---------------------------------FFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFMK 8 Q9D6K9/139-345 97.0% 11.5% TLFESWEIIGP---------------------------------YPSWWLFNALLLILQVLHAIWSYLIVQTASKALS 9 AAL89720/131-33 97.0% 10.6% TMFESWDLIGP---------------------------------YPSWWLFNGLLLVLQILHIVWSYLILRIAYKALV 10 Q95RN6/134-339 96.5% 11.1% SVEAPRIL----------------------------------PMFPAYYIFNSLLLMLLVLHVIWTYMILKIVVDSLQ 11 Q9GYR9/90-308 97.0% 9.1% AVTEAAALIQPDYI----------------------LWDYQLSPPYAPRLIVFALILLFFLHIFWTFIILRIAYRTST 12 Q21158/171-388 98.5% 11.6% VWFDAPALIQDDYE-----------------------WLNFDQQPQAPRFIMLLLTALLILHIFWAYILFKIAYDTIQ 13 Q9LDF2/76-294 98.5% 12.0% TSYQIIMTVDK---------------------------EKHPNGPILYYMFNTLLYFLLVLHIFWWVLIYRMLVKQVQ 14 Q9FZ69/73-292 98.5% 11.5% TSYEVVLELDK--------------------------DKHPIEGPIYYYMFNTLLYCLLVLHIYWWVLMYRMLVKQIQ 15 Q8W4Y5/72-289 97.5% 9.6% TSYEVLQTLDK--------------------------EKHKVDGPIYYYIFNSLLFCLLVLHIYWWVLIYRMLVKQIQ 16 Q9M6A4/73-292 98.0% 11.4% TCYELLYVLD--------------------------IQKERTTGIILYFVFNALLICLLVLHLFWFKIILRMVKNQIL 17 Q9M6A2/71-283 98.5% 8.1% TSIELLDYLDMTSA----------------------------EGTLMYYSFNTMLLMLLVFHIYWWYLICAMIVRLLK 18 YHXF_SCHPO/144- 98.0% 10.1% WGTMRTINSFDLDW-----------------------AAEQYKCWISRDVTLILLTALQLVNIYWLILILRIGYRAFT 19 LAG1_YEAST/171- 98.0% 11.5% LTEFRHEGNYVLNF-----------------------ATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIW 20 Q9GVA0/92-298 97.0% 11.1% AYIDIPLIGGL---------------------------------YPAFYMFITFLLILQVLHIYWFKLIMTMVFQLLR 21 Q9Y1V7/133-338 95.5% 10.0% IWFYGIYTYN-----------------------------------CAMAWLFCALLILQLLHFYWFSHIVKAAYASIL 22 LAG1_SCHPO/153- 98.0% 8.8% VTNAPEIIGGFHLD----------------------VPNGYIFNKPIYIAFIILLFTLQLLIYIWFGMIVKVAYRVFS 23 LSS1_HUMAN/97-3 98.0% 10.0% TSHCSLRTVPD---------------------------------IPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLT 24 CAD26440/65-270 96.0% 11.0% IVVSMWEHGFSP----------------------------------SLFLIAMLLQGLQAMHIVWSLMIVRMARKVIH 25 Q9XWE9/102-326 98.5% 7.2% TIYGAVYLGP--------------------------------QDAPFFPLLGAMLLIIFAMNVYWFNFIARMIWRVAL 26 AAH24829/116-32 97.5% 11.2% GLHLAGTNRNGNALS-------------------------GNVNVLAAKIAVLSSSCSIQVYITWTLTTVWLQRWLED 27 Q90ZM0/116-328 97.5% 6.5% GFGLARAENQELDLSN------------------------GNFNILAIRITVLASICITQAFMMWKFINFQLRRWREH 28 Q90ZM1/117-329 97.5% 8.8% GFGLAGAEKQGLNLAE------------------------GSFNVLFVRVTVLAAICITQAFMMWKFINFQLRRWREQ 29 Q90ZL9/111-323 97.5% 8.4% GFGLARAEVHTFNPDK------------------------GTLNTLLFRMVVLLLMCVSQTWMMWRFIHFQLRRWREC 30 Q924Z5/112-324 97.5% 7.4% GFGLARVENQVFDPEK------------------------GNFNTLPCRLGMLLLVCVAQAWLMWRFIHSQLRHWREY 31 Q9XXK7/123-342 97.0% 8.1% WYGLRQAESPFVDISA------------------------GNFNTAVIRLNVLLAVVLLQLFLLYSFVVFHMGRFRES 32 Q9W5C3/1330-153 94.0% 8.9% YYGIGGVRS---------------------------------------LLALGGLIALQGYLVFSFITEQLRAKREAK 33 Q9V3S7/127-403 98.5% 10.2% SLAIEAASLWS-------------------------------AMWGLPRGCLISIAILFLPQLYWFYLMVLGALKVFL 34 Q9XHZ7/65-275 95.5% 12.1% IKDAHKFGKG--------------------------------------VELPLALSGMAGMNILNVGLGLDLFHAFRR 35 Q93892/84-290 94.5% 11.3% WVNYDHIH------------------------------------FIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLS 36 Q20297/56-260 94.5% 12.3% IYNVPGLHWY------------------------------------YVLVGLGGPIIFGCINGMLFLRLLASDGFLTE 37 Q99JT6/40-239 93.0% 13.4% LQYAGQRTLG--------------------------------------TFLLAILLMLDLMIIIYFSRLLRSDFCPER 38 Q9N5G9/75-277 94.5% 13.9% FASFSMSPWY------------------------------------IASTICVLILCLASSNMVLTYRLLAADGFCGA 39 Q9XTE6/102-304 94.5% 12.4% VVSIPDLEWYV------------------------------------SIINGLVIASLASTNTVLTYRLLAADGLLGS 40 Q9BL09/35-249 96.5% 14.0% IAQDVKVPILLKL---------------------------FLVGGLTFLEYHNTHLTMAMAKSDGFFGHERQALDEDS 41 15862410/29-230 94.5% 9.6% MVSPT------------------------------------PKWFVKAGGVAMYAVSWCFMFSIWRFAWRKSIKKYHA 42 Q9LI49/25-219 91.0% 12.5% VTADN------------------------------------------PILIKAMATGLQLVSAYWFLRILRMVRHKLG 43 Q9P3N6/69-308 95.5% 14.8% YKDMWKAVHRAPTPEYIQSYYNTTSSTIDAENVMLFAAKPEPIPVWLALLYVASNLTLNTLNWYWFFKMISAVRKRFV 44 O13752/74-276 93.5% 13.7% AIEILNHINVA--------------------------------PWALSLFYLAANMSLNCLNLFWVSKMIDAIRRRAH 45 YJ86_YEAST/70-2 95.0% 12.7% FRQMWKVRDEL--------------------------------PKFSAVTMMSLNIFMNLLNVLWFKKMIRIAKKLAK 46 Q06107/95-307 95.0% 13.3% CYDFYQVRNEP------------------------------GFLVFDTIVILAGNFVLDILNVIWFSTMVSVAAKVLK 47 Q8VZR3/32-226 91.0% 13.9% LSADN------------------------------------------PIFIKAMGSGLQLVSIFWFYKIFGMMRYKLF 48 Q96MV1/44-251 96.0% 14.7% YSVYGTEPYI-------------------------------RLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVIS 49 Q93Z82/69-278 95.0% 11.6% YLHYNQVM---------------------------------RMHIFGYVLVFGVPAALGVMNLIWFGKIVRGVKKTLA 50 Q93ZA9/52-261 95.5% 13.1% YLHFHQVKQVF---------------------------------PLGFYSLLTIPPALAVMNLLWFWKITKGLIKTLS 51 Q93VP0/48-253 95.5% 14.8% YFHFDQVKSIF---------------------------------PLGFYSILTVPPALAVMNLFWFWKIFKGMLKTLS 52 Q8VC26/33-231 92.5% 13.4% SRQHYQLSL---------------------------------------ALVLLCVAGLVTVGSISISTGIRILTKDIL 53 Q9LYA1/356-566 96.0% 9.8% VAFYARGGAHG------------------------------VIPNWLWISWAIVVGIAITVSILWIWNLWIELFSERK 54 Q9LK26/35-246 97.5% 11.3% TWFYVSGGADD------------------------------VIPRWVWVSWTVVIVTAVTVSILWIWNLWVLFFQERY 55 Q9LU96/39-250 97.5% 9.4% ATFYGSGAADG------------------------------VVPRWAWLSWLVVIGFAILVSCWFHVYFSRMDSPICE 56 Q9CW26/66-297 97.5% 13.8% GATLACPCSQ---------------------------------CPWPSCATSTWARTAPRTQLYWLSLMCRGDCGLFR 57 ENSG00000083426 99.0% 12.3% GRQQGLSLLQV--------------------------------PFSIPFYCNVANAFLVAPQIYWFCLLCRKAVRLFD consensus/100% .............................................................................. consensus/90% h...............................................h.h.hh..hh..h.hhhh.hhht..h.... consensus/80% hh..............................................hhh.hhhhhh.hhphhWhhhhhphhhh.h. consensus/70% hhh.shh.......................................hhhhhhhhhhhl.hhplhWhhhhhphhhphhp