Family alignment for the TOP1Bc domain, displayed in

                     cov    pid   1 [        .         .         .         .         :         .         .         . 80 
 1 HI32816_4/1-89 100.0% 100.0%     RFSRVVFNEITKNAIKQAFEKPEQ-----LNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVA-------------------    
 2 TOP1_BACSU/1-8 100.0%  64.0%     SDCRVVFNEITKDAIKESFKHPRM-----INMDLVDAQQARRILDRLVGYKISPILWKKVK-------------------    
 3 O83409/1-89    100.0%  57.3%     PIKRIVFNEITPHAIRAAIGHPVP-----IDTAKVNAQKARRVLDRLVGYHLCPLLWHKVK-------------------    
 4 E1342630/1-89  100.0%  57.3%     FFKRVAFNEITKKAIMNAVANPRK-----LDTNLVNAQQARRALDYLVGFTLSPLLWRKLP-------------------    
 5 TOP1_THEMA/1-8 100.0%  48.3%     RKNRIVFSEITPRVIREAVKNPRE-----IDMKKVRAQLARRILDRIVGYSLSPVLWRNFK-------------------    
 6 O34204/1-89    100.0%  49.4%     GKNIITFTEITERAIKEAVKNPRE-----IDMNKVNAQLARRVLDRIVGYMISPLLWRIIK-------------------    
 7 TOP1_HELPY/1-8 100.0%  56.2%     SYPRIVFHEITQNAILNALKTPRK-----IDMSKVNAQQARRFLDRIVGFKLSSLIASKIT-------------------    
 8 O84649/1-91    100.0%  51.6%     KIQRISFNAITKGAVTEALKHPRE-----IDMALVNAQQARRFLDRIVGYKISPILGRKLQR------------------    
 9 TOP1_BORBU/1-8 100.0%  48.3%     NYKRMIFHEITETAITESLKNTRN-----IDMNLVNAGEARRILDRLYGYTISPLLWKKVA-------------------    
10 TOP1_SYNY3/1-8 100.0%  56.2%     PIKRMVFHEITQEAIRSALENCRD-----IDENLVHAQETRRILDRLVGYTLSPLLWKKIA-------------------    
11 TOP1_SYNP7/1-9 100.0%  40.0%     PRSAWSFDEITQEAIQAAHEKLSGC----RSAALVHAQETSQDSRSLGGLHPVGPALEKNC-------------------    
12 TOP1_MYCTU/1-8 100.0%  56.2%     PVKRMVFHEITEPAIRAAAEHPRD-----LDIDLVDAQETRRILDRLYGYEVSPVLWKKVA-------------------    
13 O25188/1-98    100.0%  28.6%     EIYRAEFHEITPSGIESGLKNAVLFSR--SNTNLYQSFLGRIASDQVVGFALTSYLRKSLN-------------------    
14 Q9ZKL6/1-98    100.0%  27.6%     TIYRTEFHEITKSGVEKGLNNAGLFSQ--SNLNLYYSWLGRIVSDQFIGFTLTPYLRKNIK-------------------    
15 TOPG_SULAC/1-1  98.9%  28.0%     NIRRAEFHEVTRKAILQAINQPRE-----FNVNLVKSQLVRRIEDRWIGFKLSSILQTRFWPEYCKS-------------    
16 P74759/1-89     98.9%  32.2%     NIYRITYHEITKKAILEALRNPMK-----INTNLVMSQIVRRIEDRWIGFTLSNLLKTKFN-------------------    
17 Q58907/1-91     95.5%  36.8%     NIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQVVRRIEDRWIGFRLSQKLWEVFN-------------------    
18 P95479/1-89     98.9%  36.7%     VIKRIEFHEVTRPAILRAINEARD-----INEDRVNAQLVRRIEDRWIGFELSQKLWEVFE-------------------    
19 O51934/1-89     98.9%  36.7%     SLRRIEMHEITRYGFKKARESVRF-----VDFNLVKAQIVRRVQDRWIGFELSGKLQKRFG-------------------    
20 O67037/1-88     97.8%  35.6%     NVERIEFHEVTRKAIKHAVENPRD-----FNENLVKAQLVRRIADRWVGFEVSRIVQQAFD-------------------    
21 O67226/1-88     97.8%  34.4%     NIKRAEFHEVTPKAFREAIQNPRE-----VDLNLVKAQLVRRILDRWVGFTLSHILWDAFG-------------------    
22 Q59046/1-94    100.0%  36.2%     KAKRMRFSSLTKKEIVRAFENPDE-----IDYGLVDAGESRHILDWYFGINLSRALMNAIR-------------------    
23 O58356/1-96    100.0%  35.4%     VAKRMKFSALTKRDLLNAWRNLEPT----INFGMANAGIARHILDWYWGVNLSRALTHAIKK------------------    
24 O27661/1-95    100.0%  35.8%     KTSRMKFSTLTREEIQRAYKNPIE-----VDYGQVDSGAARHILDFIFGVNISRSLMKSVKA------------------    
25 O87222/1-96    100.0%  28.1%     DIKRLWINSLEKESILNGFKNLKDGW---EFYNFFKEAQTRQISDWLIGMNASPLFTIELQR------------------    
26 O68005/1-96    100.0%  25.0%     TYKRLWINSLEKDVIRSGFQNLQPGM---NYYPFYQEAQTRQIADWLIGMNASPLYTLNLQQ------------------    
27 TOP3_ECOLI/1-9 100.0%  20.8%     QVQRCLINDLNPQAVERAIDRLRSNS---EFVPLCVSALARARADWLYGINMTRAYTILGRN------------------    
28 TOP3_HAEIN/1-9 100.0%  22.9%     KILRCLISDLNPSAVEKAVKKLQPNR---NFIPLATSALARARADWLYGINMTRAYTIRGRQ------------------    
29 TOP3_YEAST/1-1 100.0%  23.9%     QVYRAVFSHLERQHILNAARNPSR-----LDMKSVHAVGTRIEIDLRAGVTFTRLLTETLRNKLRNQ-------------    
30 O60126/1-97    100.0%  22.7%     QVIRADFNNLERSHIISAAKRPRD-----VSKNAADAVDARIELDFRLGAIFTRLQTIQLQ-KSFD--------------    
31 TOP3_HUMAN/1-9 100.0%  24.5%     QVLRARFSEITPHAVRTACENLTE-----PDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEV-------------    
32 O61660/1-102   100.0%  24.5%     DIFRARFSEITKAAITRAARNLIR-----LDEKTVAAVDCRSELDLRIGSAFTRLQTLHLRNRFRDL-------------    
33 HSD012_1/1-82   91.0%  24.4%     TVFRARFSSITDTDICNAMACLGE-----PDHNEALSVDARQELDLRIGCAFT---------------------------    
34 TOP1_MYCGE/1-8  98.9%  43.8%     KCKRITFNEITKKAVVDALKQPRN-----IDLNWVESQFARQILDRMIGFRLSRLLNSYLQ-------------------    
35 Q07711/1-96    100.0%  19.8%     TIKRLWLTSKVESSIRKAFKNILPKE---KTYGFYKEGRARELSDWLVGINLSRHFTKISRELG----------------    
36 P96583/1-91    100.0%  28.6%     PIKRLWISSVTDKAIKEGFQKLRSGK---EYENLYHSAVARAEADWIVGINATRALTTKFN-------------------    
37 Q49600/1-198    96.6%  14.9%     QVYRTEFHEVTRRGISEALKEESWKN---VDAGRVSAQILRRVADRWIGFSLSQDLWDVFKHLEIKLGELPSGSRIEVRL    
38 O28469/1-93    100.0%  33.3%     KVDRVRYSAVTEKEIRSAFSKPVK-----VDFNLANAALARQKIDLIWGATLTRLISVHSGRMG----------------    
39 TOP1_BACAN/1-9 100.0%  22.3%     KQSRVYKSSFEAAELEAALNRLESAS---KYDGLAYSAKARQYLDYLLGMNITRGCTTKLAQN-----------------    
   consensus/100%                   ...hh.hpth....h.tuhtp...............t...p...c.hhG...s...........................    
   consensus/90%                    .h.Rh.hpplp.ttl.tuhpp...........thh.u..sR...DhhhGhtho.......t...................    
   consensus/80%                    .h.Rh.hpplstpsl.pAhpp.t.......s.shsput.sRph.DhhhGhpho.hhh..ht...................    
   consensus/70%                    phhRhhFpplTcpuIhpAhcp.pp.....hshshsput.sRphhDhhlGhplo.hlhpthp...................    

                     cov    pid  81          .         1         .         .         .         .         :         . 160
 1 HI32816_4/1-89 100.0% 100.0%     --------------------------------------------------------------------------------    
 2 TOP1_BACSU/1-8 100.0%  64.0%     --------------------------------------------------------------------------------    
 3 O83409/1-89    100.0%  57.3%     --------------------------------------------------------------------------------    
 4 E1342630/1-89  100.0%  57.3%     --------------------------------------------------------------------------------    
 5 TOP1_THEMA/1-8 100.0%  48.3%     --------------------------------------------------------------------------------    
 6 O34204/1-89    100.0%  49.4%     --------------------------------------------------------------------------------    
 7 TOP1_HELPY/1-8 100.0%  56.2%     --------------------------------------------------------------------------------    
 8 O84649/1-91    100.0%  51.6%     --------------------------------------------------------------------------------    
 9 TOP1_BORBU/1-8 100.0%  48.3%     --------------------------------------------------------------------------------    
10 TOP1_SYNY3/1-8 100.0%  56.2%     --------------------------------------------------------------------------------    
11 TOP1_SYNP7/1-9 100.0%  40.0%     --------------------------------------------------------------------------------    
12 TOP1_MYCTU/1-8 100.0%  56.2%     --------------------------------------------------------------------------------    
13 O25188/1-98    100.0%  28.6%     --------------------------------------------------------------------------------    
14 Q9ZKL6/1-98    100.0%  27.6%     --------------------------------------------------------------------------------    
15 TOPG_SULAC/1-1  98.9%  28.0%     -------------------------------------------------------------------------------L    
16 P74759/1-89     98.9%  32.2%     --------------------------------------------------------------------------------    
17 Q58907/1-91     95.5%  36.8%     --------------------------------------------------------------------------------    
18 P95479/1-89     98.9%  36.7%     --------------------------------------------------------------------------------    
19 O51934/1-89     98.9%  36.7%     --------------------------------------------------------------------------------    
20 O67037/1-88     97.8%  35.6%     --------------------------------------------------------------------------------    
21 O67226/1-88     97.8%  34.4%     --------------------------------------------------------------------------------    
22 Q59046/1-94    100.0%  36.2%     --------------------------------------------------------------------------------    
23 O58356/1-96    100.0%  35.4%     --------------------------------------------------------------------------------    
24 O27661/1-95    100.0%  35.8%     --------------------------------------------------------------------------------    
25 O87222/1-96    100.0%  28.1%     --------------------------------------------------------------------------------    
26 O68005/1-96    100.0%  25.0%     --------------------------------------------------------------------------------    
27 TOP3_ECOLI/1-9 100.0%  20.8%     --------------------------------------------------------------------------------    
28 TOP3_HAEIN/1-9 100.0%  22.9%     --------------------------------------------------------------------------------    
29 TOP3_YEAST/1-1 100.0%  23.9%     -------------------------------------------------------------------------ATMTKDG    
30 O60126/1-97    100.0%  22.7%     --------------------------------------------------------------------------------    
31 TOP3_HUMAN/1-9 100.0%  24.5%     --------------------------------------------------------------------------------    
32 O61660/1-102   100.0%  24.5%     --------------------------------------------------------------------------------    
33 HSD012_1/1-82   91.0%  24.4%     --------------------------------------------------------------------------------    
34 TOP1_MYCGE/1-8  98.9%  43.8%     --------------------------------------------------------------------------------    
35 Q07711/1-96    100.0%  19.8%     --------------------------------------------------------------------------------    
36 P96583/1-91    100.0%  28.6%     --------------------------------------------------------------------------------    
37 Q49600/1-198    96.6%  14.9%     DIPSGVEVVDFRRTFDEDSSVRSRSVRLRREGDEYVVRTRISRGGDVTYTATLLDPNRKLGDRNGVRPELVRVRASVNGE    
38 O28469/1-93    100.0%  33.3%     --------------------------------------------------------------------------------    
39 TOP1_BACAN/1-9 100.0%  22.3%     --------------------------------------------------------------------------------    
   consensus/100%                   ................................................................................    
   consensus/90%                    ................................................................................    
   consensus/80%                    ................................................................................    
   consensus/70%                    ................................................................................    

                     cov    pid 161          .         .         .         2        ] 209
 1 HI32816_4/1-89 100.0% 100.0%     -----------RGLSAGRVQSVAVKLLVEREREIKAFQ-----PEEYWE    
 2 TOP1_BACSU/1-8 100.0%  64.0%     -----------KGLSAGRVQSVALRLIIDREKEINDFK-----PEEYWT    
 3 O83409/1-89    100.0%  57.3%     -----------NGLSAGRVQSVALRLICEREVEVKRFV-----PEEYWT    
 4 E1342630/1-89  100.0%  57.3%     -----------GCKSAGRVQSVALRLICDREDEIERFK-----SEEYWD    
 5 TOP1_THEMA/1-8 100.0%  48.3%     -----------SNLSAGRVQSATLKLVCDREREILRFV-----PKKYHR    
 6 O34204/1-89    100.0%  49.4%     -----------DARSAGRVQSAALKIICERERERYRFV-----PQKYFK    
 7 TOP1_HELPY/1-8 100.0%  56.2%     -----------KGLSAGRVQSAALKLVIDKEREIKAFK-----PLTYFT    
 8 O84649/1-91    100.0%  51.6%     ----------WSGVSAGRVQSVALKLVVDREYAIERFV-----PVEFWN    
 9 TOP1_BORBU/1-8 100.0%  48.3%     -----------YGLSAGRVQSVGLKLLIEKEKTRINFK-----KANYYS    
10 TOP1_SYNY3/1-8 100.0%  56.2%     -----------WGLSAGRVQSVAVRLIVQRERARRAFK-----TAGYWD    
11 TOP1_SYNP7/1-9 100.0%  40.0%     -----------LGPIAGRVQSVAVRLLVQRERARRAFR-----QGSYWD    
12 TOP1_MYCTU/1-8 100.0%  56.2%     -----------PKLSAGRVQSVATRIIVARERDRMAFR-----SAAYWD    
13 O25188/1-98    100.0%  28.6%     ----------LSELSAGRVQTPALALICQRDQEIRDFDKLDAEEKVEYQ    
14 Q9ZKL6/1-98    100.0%  27.6%     ----------NFEVGAGRVQTPALSILVELDRKIQAFEQKNNDEKLSYS    
15 TOPG_SULAC/1-1  98.9%  28.0%     SSNKQLNCNENKNLSAGRVQTPVLSWIVDRYTEYQRN------KSRVYY    
16 P74759/1-89     98.9%  32.2%     ----------GHNHGAGRVQTPVLGWIVDKTIKYKSA------MGYVVY    
17 Q58907/1-91     95.5%  36.8%     ----------KNYLSAGRVQTPVLGWIIERYNEHK--------IK-VPY    
18 P95479/1-89     98.9%  36.7%     ----------NYNLSAGRVQTPVLGWIVQRYKEFTES------ETDFLG    
19 O51934/1-89     98.9%  36.7%     ----------RSNLSAGRVQSTVLGWIVEREEEYKKS------EKDFTL    
20 O67037/1-88     97.8%  35.6%     ----------KHWLSGGRVQIPVLGWIIEREKLYRK-------KKHVVQ    
21 O67226/1-88     97.8%  34.4%     ----------KKWLSAGRVQTPVLGWVIKRYEESKE-------KKGEIL    
22 Q59046/1-94    100.0%  36.2%     ------AVNRWKTMSVGRVQGPALAFLTERELEIKKFI-----PKPYWV    
23 O58356/1-96    100.0%  35.4%     ------ASGKWVVLSTGRVQGPTLKFLVEREREIQSFV-----PRPYWV    
24 O27661/1-95    100.0%  35.8%     ------ATNRFIKLSAGRVQTPTLAILVEREKEIRDFK-----PVPYWI    
25 O87222/1-96    100.0%  28.1%     -------KGINGVYSIGRVQTPTLYLVYKRYLEIKNFK-----PTPYFE    
26 O68005/1-96    100.0%  25.0%     -------KGVQGTFSLGRVQTPTLYLIFQRQEAIENFR-----KEPFFE    
27 TOP3_ECOLI/1-9 100.0%  20.8%     -------AGYQGVLSVGRVQTPVLGLVVRRDEEIENFV-----AKDFFE    
28 TOP3_HAEIN/1-9 100.0%  22.9%     -------TGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQ-----PKDFFE    
29 TOP3_YEAST/1-1 100.0%  23.9%     AKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNFV-----PEEFWY    
30 O60126/1-97    100.0%  22.7%     -------ILQNKIISYGPCQFPTLGFVVDRWQRVEDFV-----PETYWH    
31 TOP3_HUMAN/1-9 100.0%  24.5%     --------LAEQLISYGSCQFPTLGFVVERFKAIQAFV-----PEIFHR    
32 O61660/1-102   100.0%  24.5%     ----LGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFV-----SEPFWK    
33 HSD012_1/1-82   91.0%  24.4%     ----------SSLISFGPCQTPTLGFCVERHDKIQSFK-----PETYWV    
34 TOP1_MYCGE/1-8  98.9%  43.8%     ------------AKSAGRVQSVALRFLEEREKEIAKFV-----PRFWWT    
35 Q07711/1-96    100.0%  19.8%     ---------NDGVIHIGRVSSPTLNMVYNRENNIKGFK-----GKKFYK    
36 P96583/1-91    100.0%  28.6%     -----------AQLSCGRVQTPTLAMIAKREADIQAFT-----PVPYYG    
37 Q49600/1-198    96.6%  14.9%     PVDPNVKLEPMTWLSAGRVQTPVLGWIIDRAREYR--------ETEFYA    
38 O28469/1-93    100.0%  33.3%     ----------KDFLSVGRVQTPTLRLIVDRELEIQNFK-----PEKYYE    
39 TOP1_BACAN/1-9 100.0%  22.3%     ----------KFLLSSGRVQMCLLHEIRQRELAIENYR-----EQSYYH    
   consensus/100%                   ................G.sp.shh..h.th...................    
   consensus/90%                    .............huhGpsQ.sslthlhp+..th.t..........hh.    
   consensus/80%                    .............hShGRVQsssLthlhpR..thpth.......t.aa.    
   consensus/70%                    ...........thlSsGRVQossLthlhcRppchppF.......p.aat