cov pid 1 [ . . . . : . . . 80 1 TOP1_HUMAN 100.0% 100.0% LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 2 TOP1_CRIGR 100.0% 98.7% LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 3 Q12855 100.0% 100.0% LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 4 TOP1_MOUSE 100.0% 98.9% LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 5 Q12856 100.0% 99.5% LFRGRGNHPKTGMLKRRIM-PEDIIINCSKDAKVPS---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 6 P79994 100.0% 95.8% LFRGRGNHPKMGMLKRRIM-PEDIIINCSKDSKVPP---PPPGH-KWKEVRHDNKVTWLVSWTENIQGS-IKYIMLNPSS 7 TOP1_XENLA 100.0% 90.7% LFRGRGDHPKMGKLKKRIM-PEDIIINCSKDSKIPV---APAGH-KWKEVRHDGKVTWLVSWTENIQGS-IKYIMLNPSS 8 TOP1_DROME 95.8% 69.3% LFRGRGEHPKMGMIKRRIQ-ASDVSINCGKDSKVPS---PPPGS-RWKEVRHDNTVTWLASWIENVQGQ-VKYIMLNPSS 9 Q27529 97.1% 66.5% VFRGRGGHPKMGLIKKRIM-PEDVIINCGKDTEIPK---PPPGH-KWKEVRHDNTVTWLCSWTESVLGQ-NKYIMLNPSS 10 TOP1_YEAST 98.1% 41.8% LFRGRGAHPKTGKLKRRVN-PEDIVLNLSKDAPVPP---APEGH-KWGEIRHDNTVQWLAMWRENIFNS-FKYVRLAANS 11 O60013 98.1% 43.8% LFRGRGDHPKTGKLKTRVV-PEQVIINIGKDSVIPS---PPPGH-NWKEVRHDNTVTWLATWNENVNNN-VKYVFLSAGS 12 O59891 98.1% 43.0% LFKGRGEHPKKGTVKNRLR-PEDIIINIGKEAPIPV---PNIPG-QWKGIQHDNTVTWLAHWKENVNGN-AKYVFLSAGS 13 TOP1_SCHPO 98.1% 41.0% LFRGRGSHPKTGSLKRRVY-PEQITINIGEGVPVPE---PLPGH-QWAEVKHDNTVTWLATWHENINNN-VKYVFLAAGS 14 O13463 98.1% 39.7% LFRGRGEHPKTGRVKARVQ-PEQITINIGKEARVPP---PPEGH-KWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANS 15 CAU41342_1 98.1% 39.9% LFRGRGAHPKTGKLKRRVV-SEQVTLNLGKDAKIPE---PPAGH-QWGEIRHDNEVTWLAMWKENISDS-LKYVRFANNS 16 TOP1_CANAL 98.1% 39.7% LFRGRGAHPKTGKLKRRVV-SEQVTLNLGKDAKIPE---PPAGH-QWGEIRHDNEVTWLAMWKENISDS-LKYVRFANNS 17 JC6519 98.1% 38.1% LFRGRGEHPKTGRVKARVQ-PEQITINIGKEARVPP---PPEGH-KWKEVKHDQEGTWLAMWQENINGN-YKYVMLAANS 18 TOP1_ARATH 95.0% 44.7% LFRGRGEHPKMGKLKKRIH-PCEITLNIGKGAPIPEC--PIAGE-RWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGS 19 Q94705 98.1% 43.1% LFLGRGAHPKTGLVKKRIE-AEDITINIGKGVPVPE---PPPGH-KWCKVVHDDKVAWLAMWKENINNG-FKYVWLHASS 20 O24307 95.0% 44.7% LFRGRGEHPKMGRLKKRIH-PSDIVINIGSEAQVPEC--PIPGE-GWKDIRNDNTVTWLCYWSDPINPKLFKYVFLAASS 21 P93119 97.9% 41.1% VVQRSWRASKDPQVKKNVYSQIDITINIGKDAPIPEP--PIPGE-RWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASS 22 Q26024 99.2% 35.6% LFRGRGEHPKQGLLKKRIF-PEDVVINISKDAPVPRLYDNMCGH-NWGDIYHDNKVTWLAYYKDSINDQ-IKYTFLSAQS 23 TOP1_USTMA 98.1% 28.2% LFLGRGAHPKAGKVKRRIS-PGDITINHSGDHPAPQ---PPAGMGDWAEVVEKKDVTWLAYWKENINGQ-YKYVFLDATS consensus/100% lh.tphttsK.s.lKtpl....pl.lNhutt..hP....s..s..tWttl.pctpstWLs.a.-sl.st..KYhhhtstS consensus/90% LFpGRGtHPKhGhlKpRl..spplhlNhucts.lP....s..Gp.pWt-lhHDppVTWLs.Wp-slpsp.hKYlhLsssS consensus/80% LFRGRGtHPKhGhlK+Rl..spplhINhuK-u.lP....P.sGc.pWtEl+HDspVTWLs.WpEsIpsp.hKYlhLsssS consensus/70% LFRGRGpHPKhGhlK+Rlh.PE-IhINhuK-u.lPp...PPsGH.pWpEl+HDNpVTWLs.WpENIpsp.hKYlhLsssS cov pid 81 . 1 . . . . : . 160 1 TOP1_HUMAN 100.0% 100.0% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 2 TOP1_CRIGR 100.0% 98.7% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 3 Q12855 100.0% 100.0% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 4 TOP1_MOUSE 100.0% 98.9% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 5 Q12856 100.0% 99.5% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 6 P79994 100.0% 95.8% RIKGEKDWQKYETARRLKKCVDKIR-NQYREDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 7 TOP1_XENLA 100.0% 90.7% RIKGEKDWQKYETARRLKMCVEKIR-NTYKEDWKSKEMKVRQ--------------------RAVALYFIDKLALRAGNE 8 TOP1_DROME 95.8% 69.3% KLKGEKDHIKYETARRLDKVIDKIR-ATYRDEWKSKEMRVRQ--------------------RAVALYFIDKLALRAGNE 9 Q27529 97.1% 66.5% KIKGEKDFEKYETARRLKKKIGGIR-ERYTDDFKSKEMRVRQ--------------------RATALYFIDKLALRAGNE 10 TOP1_YEAST 98.1% 41.8% SLKGQSDYKKFEKARQLKSYIDAIR-RDYTRNLKSKVMLERQ--------------------KAVAIYLIDVFALRAGGE 11 O60013 98.1% 43.8% SLKGQSDLKKYEKARELKLYIDNIR-KQYRKELEDKLMEVRQ--------------------RATAMYLIDLFALRAGNE 12 O59891 98.1% 43.0% AWKGQSDRAKFEKARELIKHVDKIR-KDYTADLKSKIMADRQ--------------------RATALYFIDRLALRAGNE 13 TOP1_SCHPO 98.1% 41.0% SLKGQSDLKKYEKSRKLKDYIDDIR-KGYRKDLKNELTVERQ--------------------RGTAMYLIDVFALRAGNE 14 O13463 98.1% 39.7% DVKGQSDYKKFEKARELKKHIARIR-KDYQKNLKHELMVERQ--------------------KATAVYLIDQFALRAGNE 15 CAU41342_1 98.1% 39.9% SVKGQSDFKKFETARKLRDHVDSIR-KDYTKMLKSEKMQDRQ--------------------MATAMYLIDVFALRAGGE 16 TOP1_CANAL 98.1% 39.7% SVKGQSDFKKFETARKLRDHVDSIR-KDYTKMLKSEKMQDRQ--------------------MATAMYLIDVFALRAGGE 17 JC6519 98.1% 38.1% DVKGQSDYKKFEKARELKKHIARIR-KDYQKNLKHELMVERQKATAVYLIDQFALRAMVERQKATAVYLIDQFALRAGNE 18 TOP1_ARATH 95.0% 44.7% SLKGLSDKEKYEKARNLTDHIDNIR-TTYTKNFTAKDVKMRQ--------------------IAVATYLIDKLALRAGNE 19 Q94705 98.1% 43.1% AVKGRSDMKKFEVARKLKDHIEKIR-KKYLKELGSEELEERQ--------------------RATAIYLIDRLALRVGNE 20 O24307 95.0% 44.7% SLKGQSDKEKYEKARMLKDYIGNIR-AYYTKDFTSKDITKQQ--------------------IAVATYLIDKLALRAGNE 21 P93119 97.9% 41.1% SLKGKVTREKYEKSRKLKDYIEGIRAAAYTKDFASKDSKKRQ--------------------IAVATYLIDKLALRAGNE 22 Q26024 99.2% 35.6% KFKGYKDLMKYENARKLKSCVHKIR-EDYKNKMKNKNIIDKQ--------------------LGTAVYLIDFLALRVGGE 23 TOP1_USTMA 98.1% 28.2% NFKTNSDREKFEKARKLDTVVKQIR-RDVNKNLKSKVRHERQ--------------------IATIVCLIDNFSLRAGNE consensus/100% thKs..sh.KaE.uR.L..hlttIR.t.h.t.httc....pQ....................hushhhhID.huLRsGsE consensus/90% phKGppDhtKaEpARpLcphlttIR.ttYpcphpsc.h..RQ....................hAsAhYhID.hALRAGsE consensus/80% plKGppDhpKaEpARcL+phlcpIR.ppYpcphcsc.hh.RQ....................hAsAhYhIDhhALRAGNE consensus/70% plKGppDhpKaEpARcLKchl-pIR.ppYpcshKSK.hp.RQ....................hAsAhYhIDphALRAGNE cov pid 161 . . . 2 . . . . 240 1 TOP1_HUMAN 100.0% 100.0% KEEGETADTVGCCSLRVEHINLHPELDG-----------------------------QEYVVEFDFLGKDSIRYYNKVPV 2 TOP1_CRIGR 100.0% 98.7% KEEGETADTVSCCSLRVEHINLHPELDG-----------------------------QEYVVEFDFPGKDSIRYYNKVPV 3 Q12855 100.0% 100.0% KEEGETADTVGCCSLRVEHINLHPELDG-----------------------------QEYVVEFDFLGKDSIRYYNKVPV 4 TOP1_MOUSE 100.0% 98.9% KEEGETADTVGCCSLRVEHINLHPELDG-----------------------------QEYVVEFDFPGKDSIRYYNKVPV 5 Q12856 100.0% 99.5% KEEGETADTVGCCSLRVEHINLHPELDG-----------------------------QEYVVEFDFLGKDSIRYYNKVPV 6 P79994 100.0% 95.8% KEEGETADTVGCCSLRVEHIKLHPELDG-----------------------------QEYVVEFDFLGKDSIRYYNKVPV 7 TOP1_XENLA 100.0% 90.7% KEEGETADTVGCCSLRVEHINLFQELDG-----------------------------QEFVVEFDFPGKDSIRYYNKVPV 8 TOP1_DROME 95.8% 69.3% KDE-DQADTVGCCSLRVEHVQLHKELNG-----------------------------KENVVVFDFPGKDSIRYYNEVEV 9 Q27529 97.1% 66.5% KDVDEAADTVGCCSLRVEHIKLFDSAKLNEDDKKE----------------------KEFVVEFDFLGKDSIRYFNRVSV 10 TOP1_YEAST 98.1% 41.8% KSE-DEADTVGCCSLRYEHVTLKPPNTV----------------------------------IFDFLGKDSIRFYQEVEV 11 O60013 98.1% 43.8% KGE-DEADTVGCCSLRYEHISLSPPNTV----------------------------------VFDFLGKDSIRYYNEVQV 12 O59891 98.1% 43.0% KGE-DEADTVGCCSLRYEHVTLSPPNTI----------------------------------IFDFLGKDSMRFHQEVEV 13 TOP1_SCHPO 98.1% 41.0% KGE-DEADTVGCCSLRYEHVTLKPPRTV----------------------------------VFDFLGKDSIRYYNEVEV 14 O13463 98.1% 39.7% KGE-DEAETVGCCSLKYENVTLKPPNKV----------------------------------IFDFLGKDSIRFYDEVEV 15 CAU41342_1 98.1% 39.9% KGE-DEADTVGCCSLRYEHVTLKPPNKV----------------------------------IFDFLGKDSIRFYQEVEV 16 TOP1_CANAL 98.1% 39.7% KGE-DEADTVGCCSLRYEHVTLKPPNKV----------------------------------IFDLLGKDSIRFYQEVEV 17 JC6519 98.1% 38.1% KGE-DEAETVGCCSLKYENVTLKPPNKV----------------------------------IFDFLGKDSIRFYDEVEV 18 TOP1_ARATH 95.0% 44.7% KDD-DEADTVGCCTLKVGNVECIPPNKIK----------------------------------FDFLGKDSIQYVNTVEV 19 Q94705 98.1% 43.1% KDE-DTADTVGCCSLRVEHVTLKEPASVT----------------------------------LDFLGKDSMRYHNTVDV 20 O24307 95.0% 44.7% KDD-DEADTVGCCTLKVENVTRETPNKLK----------------------------------FNFLGKDSIKYENTVEV 21 P93119 97.9% 41.1% KDD-DEADTVGCCTLKVENVETKRPNILK----------------------------------FDFLGKDSIRYQNEVEV 22 Q26024 99.2% 35.6% KDIDEEADTVGCCSLRVEHISFAHDIPFKSVDSKEQKTNDEKVNKIPLPTNLESISSEDCYITLDFLGKDSIRYFNTVKI 23 TOP1_USTMA 98.1% 28.2% KGE-DETETYGVCSLRCEHAQIKMPDTIH----------------------------------LEFLGKDSMKFEEDLKI consensus/100% Kt..-ts-ThusCoL+htphph.....h...................................hph.GKDShpa.ppl.l consensus/90% Kt-.-pA-TVGCCoL+hEplph....ph...................................hDF.GKDSh+a.ppV.V consensus/80% Kt-.-pADTVGCCSL+hEplplp...ph...................................FDFLGKDSIRaapcV.V consensus/70% KtE.-pADTVGCCSLRhEHlsLcs..ph...................................FDFLGKDSIRaascV.V cov pid 241 : . . . . 3 . . 320 1 TOP1_HUMAN 100.0% 100.0% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDLMEGLTAKVFRTYNASITLQQ 2 TOP1_CRIGR 100.0% 98.7% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDLMEGLTAKVFRTYNASITLQQ 3 Q12855 100.0% 100.0% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDLMEGLTAKVFRTYNASITLQQ 4 TOP1_MOUSE 100.0% 98.9% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDLMEGLTAKVFRTYNASITLQQ 5 Q12856 100.0% 99.5% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------GILNKHLQDLMEGLTAKVFRTYNASITLQQ 6 P79994 100.0% 95.8% E-KRVFKNLQLFMEN------------KQPEDDLFDRLNT----------SILNKHLQDLMEGLTAKVFRTYNASITLQQ 7 TOP1_XENLA 100.0% 90.7% E-KRVFKNLQLFMEN------------KQPDDDLFDRLNT----------SILNKHLQDLMEGLTAKVFRTYNASITLQQ 8 TOP1_DROME 95.8% 69.3% E-KRVFKNLELFMEH------------KKEGDDLFDRLNT----------QVLNEHLKELMEGLTAKVFRTYNASKTLQS 9 Q27529 97.1% 66.5% E-KRVYKNLKIFMEG------------KAPSDDLFDRLDT----------ATLNDHLRSLMDGLTVKVFRTYNASITLQE 10 TOP1_YEAST 98.1% 41.8% D-KQVFKNLTIFKRP-----------PKQPGHQLFDRLDP----------SILNKYLQNYMPGLTAKVFRTYNASKTMQD 11 O60013 98.1% 43.8% D-PQVFKNLKIFKRS-----------PKTEGDMLFDRLNT----------SKLNNHLTSLMPGLSAKVFRTHNASYTMSE 12 O59891 98.1% 43.0% D-PQVFKNIKLFKAD-----------PKKKGDDIFDRLTT----------TLLNKHLNGMMPGLTAKVFRTYNASWTFQE 13 TOP1_SCHPO 98.1% 41.0% D-PQVFKNLKIFKRP-----------PKKEGDLIFDRLST----------NSLNKYLTSLMDGLSAKVFRTYNASYTMAE 14 O13463 98.1% 39.7% D-PQVFKNLKIFKKP-----------PKKEGDEIFDRLTT----------SALNKHLSQYMPGLTAKVFRTYNASHTMSE 15 CAU41342_1 98.1% 39.9% D-KQVFKNLRIFKKS-----------PKQPGDDLFDRINP----------SLVNRQLQNYMKGLTAKVFRTYNASKTMQD 16 TOP1_CANAL 98.1% 39.7% D-KQVFKNLRIFKKS-----------PKQPGDDLFDRINP----------SLVNRQLQNYMKGLTAKVFRTYNASKTMQD 17 JC6519 98.1% 38.1% D-PQVFKNLKIFKKP-----------PKKEGDEIFDRLTT----------SALNKHLSQYMPGLTAKVFRTYNASHTMSE 18 TOP1_ARATH 95.0% 44.7% E-PLVYKAIGQFQAG------------KSKTDDLFDELDT----------SKLNAHLKELVPGLTAKVFRTYNASITLDE 19 Q94705 98.1% 43.1% D-PRVFKNLSEFMYKGGNKKA-----PKKPENDLFDQLTT----------SSLNKYLKGFMENLSAKVFRTYNASLTLEK 20 O24307 95.0% 44.7% E-LPVYNAILKFQKD------------KGPGDDLFDKLDT----------NKLNAHLKELMPGLTAKVFRTFNASITLDD 21 P93119 97.9% 41.1% E-PRVFSAIEQFRSG------------KEGGDDLFDQLDT----------SKLNAHLKELMPGLTAKVFRTYNASITLDE 22 Q26024 99.2% 35.6% D-KQAYINIIIFCKN------------KNRDEGVFDQITC----------SKLNEYLKEIMPTLSAKVFRTYNASITLDQ 23 TOP1_USTMA 98.1% 28.2% TNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQG consensus/100% p...sa.sl..F...............Kt.tp.lFst.ps..........t.lNt.Lpthh.sLosKVFRTaNAShThtt consensus/90% -..pVapslt.Fhts............Kp.t-.lFDplss..........s.lNtaLpphM.GLoAKVFRTYNAShThpp consensus/80% -..pVFKNlphFhcs............Kp.tDplFDcLso..........shLNpaLpphM.GLoAKVFRTYNAShThpp consensus/70% -..pVFKNLplFhcs............Kp.tD-LFDRLsT..........uhLNcaLpphM.GLTAKVFRTYNAShThpp cov pid 321 . . : . . . . 4 400 1 TOP1_HUMAN 100.0% 100.0% QLKELTA------------------------------------------------------------------------- 2 TOP1_CRIGR 100.0% 98.7% QLKELTA------------------------------------------------------------------------- 3 Q12855 100.0% 100.0% QLKELTA------------------------------------------------------------------------- 4 TOP1_MOUSE 100.0% 98.9% QLKELTA------------------------------------------------------------------------- 5 Q12856 100.0% 99.5% QLKELTA------------------------------------------------------------------------- 6 P79994 100.0% 95.8% QLKELTN------------------------------------------------------------------------- 7 TOP1_XENLA 100.0% 90.7% QLDELTN------------------------------------------------------------------------- 8 TOP1_DROME 95.8% 69.3% QLDLLTD------------------------------------------------------------------------- 9 Q27529 97.1% 66.5% QLIKLTN------------------------------------------------------------------------- 10 TOP1_YEAST 98.1% 41.8% QLDLIPN------------------------------------------------------------------------- 11 O60013 98.1% 43.8% QLKNTPK------------------------------------------------------------------------- 12 O59891 98.1% 43.0% QLKNTPT------------------------------------------------------------------------- 13 TOP1_SCHPO 98.1% 41.0% ELKKMPK------------------------------------------------------------------------- 14 O13463 98.1% 39.7% LLKSMHA------------------------------------------------------------------------- 15 CAU41342_1 98.1% 39.9% QIDIIEN------------------------------------------------------------------------- 16 TOP1_CANAL 98.1% 39.7% QIDIIEN------------------------------------------------------------------------- 17 JC6519 98.1% 38.1% LLKSMHA------------------------------------------------------------------------- 18 TOP1_ARATH 95.0% 44.7% MLSQ---------------------------------------------------------------------------- 19 Q94705 98.1% 43.1% ELAKMPE------------------------------------------------------------------------- 20 O24307 95.0% 44.7% KLNK---------------------------------------------------------------------------- 21 P93119 97.9% 41.1% MVRCKLLSR----------------------------------------------------------------------- 22 Q26024 99.2% 35.6% QLKRIKEVYGKTTYSLYSGETELHKSKKRKSSHLTSDTNILSDASDSTINDVNNEYDENGINKKLSYATTVGKENDVDDK 23 TOP1_USTMA 98.1% 28.2% LLEQTEEWLKSRPN------------------------------------------------------------------ consensus/100% .l.............................................................................. consensus/90% .lp.h........................................................................... consensus/80% .Lcph.t......................................................................... consensus/70% pLcph.t......................................................................... cov pid 401 . . . . : . . . 480 1 TOP1_HUMAN 100.0% 100.0% ------PDENIPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQTKIDAKKEQLA--------------------- 2 TOP1_CRIGR 100.0% 98.7% ------PDENVPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQSKIDAKKDQLA--------------------- 3 Q12855 100.0% 100.0% ------PDENIPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQTKIDAKKEQLA--------------------- 4 TOP1_MOUSE 100.0% 98.9% ------PDENVPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQSKIDAKKDQLA--------------------- 5 Q12856 100.0% 99.5% ------PDENIPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQTKIDAKKEQLA--------------------- 6 P79994 100.0% 95.8% ------PDDNIPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQSKIDAKKEQLA--------------------- 7 TOP1_XENLA 100.0% 90.7% ------SDDNVPAKILSYNRANRAVAILCNHQRAPPKTFE-KSMMNLQGKIDAKKDQLA--------------------- 8 TOP1_DROME 95.8% 69.3% ------PSATVPEKLLAYNRANRAVAILCNHQRSVPKSHE-KSMENLKEKIKAKREAIE--------------------- 9 Q27529 97.1% 66.5% ------PKDNVAAKILSYNRANRQVAILCNHQRAVSKGFD-ESMQKLEQKIKDKKKEVK--------------------- 10 TOP1_YEAST 98.1% 41.8% -------KGSVAEKILKYNAANRTVAILCNHQRTVTKGHA-QTVEKANNRIQELEWQKIRCKRAILQLDKDLLKKE-PKY 11 O60013 98.1% 43.8% -------DASISDKVLAYNRANRMVAILCNHQRTISKTHS-AQMERIEDKILALKYQKIRLRKAILTLDPKLEKSR-PDL 12 O59891 98.1% 43.0% -------NGTVAEKIAAYNTANRDVAILCNHQKSVSKGFE-GSFAKAEDKIRALKYQRLKLRLQLFSLNPKIKKKH-PEL 13 TOP1_SCHPO 98.1% 41.0% -------NLTLADKILFYNRANRTVAILCNHQRSVTKNHD-VQMERFAERIKALQYQRMRLRKMMLNLEPKLAKSK-PEL 14 O13463 98.1% 39.7% -------TGNNAEKVKAYNDANRKVAILCNHKRTVGAVTR-DQMEKMSERIKGQRYQKWRLKQMMLDLDPSLKKKKGAQF 15 CAU41342_1 98.1% 39.9% -------EGTVAEKVAKFNAANRTVAILCNHQRTVSKTHG-DSVQRINDKLKKFMWQKIRLKKMILQLEPKLKKKD-SKY 16 TOP1_CANAL 98.1% 39.7% -------EGTVAEKVAKFNAANRTVAILCNHQRTVSKTHG-DSVQRINDKLKKFMWQKIRLKKMILQLEPKLKKKD-SKY 17 JC6519 98.1% 38.1% -------TGNNAEKVKAYNDANRKVAILCNHKRTVGAVTR-DQMEKMSERIKGQRYQKWRLKQMMLDLDPSLKKKKGAQF 18 TOP1_ARATH 95.0% 44.7% ---E-TKDGDVTQKIVVYQKANKEVAIICNHQRTVSKTHG-AQIEKLTARIEELKEVLKELKTNLDRAK----------- 19 Q94705 98.1% 43.1% ----SLIKATADEKVLFYNRCNREVAILCNHQRSLSKTHT-ETMGKIDEKIAEFKKEKLQQQIAYLKGKGKKPVLS---- 20 O24307 95.0% 44.7% ---D-TKDGDAAEKIVVYQHANKQVAIICNHQRSVSKSHS-AQMTKLNEKIDELQDVLKELKVDLDRAR----------- 21 P93119 97.9% 41.1% ---E-TKGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHS-AQMVRLNEKIEELKGLLKELQEDLTRVN----------- 22 Q26024 99.2% 35.6% NSPIEVDVSNINELINFYNNANREVAILCNHQRSIPKQHD-TTMSKIKKQIELYNEDIKEYKKYLQHLKKN--------- 23 TOP1_USTMA 98.1% 28.2% ---AAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKV consensus/100% .........s.sthh..aptsN+.VAIlCNHp+s.s..h...ph.phttpl......h...................... consensus/90% .......pts.stKlh.YptAN+tVAIlCNHQRs.stsht.tph.phpp+Itthp..hh..................... consensus/80% .......ptshstKlh.YNpANRtVAILCNHQRsssKsat.tph.phpp+Icthp.phh..................... consensus/70% .......stslstKllsYNcANRtVAILCNHQRsssKsap.ppM.plppKIcth+.phh..................... cov pid 481 . 5 . . . . : . 560 1 TOP1_HUMAN 100.0% 100.0% ---------------DARR-----------------DLKSA------KADAKV--------------------------- 2 TOP1_CRIGR 100.0% 98.7% ---------------DARR-----------------DLKSA------KADAKV--------------------------- 3 Q12855 100.0% 100.0% ---------------DARR-----------------DLKSA------KADAKV--------------------------- 4 TOP1_MOUSE 100.0% 98.9% ---------------DARR-----------------DLKSA------KADAKV--------------------------- 5 Q12856 100.0% 99.5% ---------------DARR-----------------DLKSA------KADAKV--------------------------- 6 P79994 100.0% 95.8% ---------------DARR-----------------ELKSA------KADAKV--------------------------- 7 TOP1_XENLA 100.0% 90.7% ---------------DARR-----------------EFKSA------KADAKV--------------------------- 8 TOP1_DROME 95.8% 69.3% ---------------KCES-----------------EYHS---------------------------------------- 9 Q27529 97.1% 66.5% ---------------EAEA-----------------ALKSA------RGAEK---------------------------- 10 TOP1_YEAST 98.1% 41.8% FEE-----------IDDLTKEDEATIHKRIIDREIEKYQRKFVRENDKRKFEK--------------------------- 11 O60013 98.1% 43.8% SEA-----------VSDIDEDWIKEHQKVLIEKEYDKIKRKFQKDNEKLISQN--------------------------- 12 O59891 98.1% 43.0% AED-----------ESDVDDEFMERHEAELLEKALENAKKKWDTDNVKLEGDG--------------------------- 13 TOP1_SCHPO 98.1% 41.0% LAK-----------EEGITDSWIVKHHETLYELEKEKIKKKFDRENEKLAAEDP-------------------------- 14 O13463 98.1% 39.7% FEL-----------DEDIDKEWIKEHQAFLIEEQAQKIKKKFEKDNEKLLAEG--------------------------- 15 CAU41342_1 98.1% 39.9% FEE-----------IDDLLKEDIEHIHHTIIKRQREQAKKKLERDNEKLKLEG--------------------------- 16 TOP1_CANAL 98.1% 39.7% FEE-----------IDDLIKEDIEHIHHTIIKRQREQAKKKLERDNEKLKLEG--------------------------- 17 JC6519 98.1% 38.1% FEL-----------DEDIDKEWIKEHQAFLIEEQAQKIKKKFEKDNEKLLAEG--------------------------- 18 TOP1_ARATH 95.0% 44.7% ---------------KGKP-----------------PLEGSDGK------------------------------------ 19 Q94705 98.1% 43.1% ---------------DSESDEDTPKKATPKKATPKKETKSSDEATPNKKRKKD--------------------------- 20 O24307 95.0% 44.7% ---------------KGKS-----------------PTKSSDGK------------------------------------ 21 P93119 97.9% 41.1% ---------------KGKP-----------------PLKNSDGKPKRNLNLKR--------------------------- 22 Q26024 99.2% 35.6% ---------------SDKK----------------FIFVSKVSTLDGTLRPNK--------------------------- 23 TOP1_USTMA 98.1% 28.2% KEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRS consensus/100% ...............ps....................h.t........................................ consensus/90% ...............ps....................hcpt....................................... consensus/80% ...............csht.................th+pt......ph..p............................ consensus/70% ...............cshp.................phKpt......+hthc............................ cov pid 561 . . . 6 . . . . 640 1 TOP1_HUMAN 100.0% 100.0% ------------------MKDAKTKKVVESKKK---------------AVQRLEEQLMKLEVQATDREENKQIALGTSKL 2 TOP1_CRIGR 100.0% 98.7% ------------------MKDAKTKKVVESKKK---------------AVQRLEEQLMKLEVQATDREENKQIALGTSKL 3 Q12855 100.0% 100.0% ------------------MKDAKTKKVVESKKK---------------AVQRLEEQLMKLEVQATDREENKQIALGTSKL 4 TOP1_MOUSE 100.0% 98.9% ------------------MKDAKTKKVVESKKK---------------AVQRLEEQLMKLEVQATDREENKQIALGTSKL 5 Q12856 100.0% 99.5% ------------------MKDAKTKKVVESKKK---------------AVQRLEEQLMKLEVQATDREENKQIALGTSKL 6 P79994 100.0% 95.8% ------------------RRDEKSKKAVESKKK---------------AVQRIEEQLMKLEVQATDREENKQIALSTSKL 7 TOP1_XENLA 100.0% 90.7% ------------------RRDEKTKKLVESKKK---------------AVQRIEEQLMKLEVQATDREENKQIALGTSKL 8 TOP1_DROME 95.8% 69.3% -------------------RDEKKGK----------------------QLERLRDQLKKLELQETDRDENKTIALGTSKL 9 Q27529 97.1% 66.5% ---------------------EKAQK----------------------KYDRLKEQLKKLKISRTDKDENKQIALGTSKL 10 TOP1_YEAST 98.1% 41.8% --EELLPESQLKEWLEKVDEKKQEFEKELKTGEVELKSSWNSVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSKI 11 O60013 98.1% 43.8% --ETPMPESRLEKFLEKINEMKEEFKIENEKGRVESKTRGITIETLDLQIKKINERIHQMKALMIDKAQNKTTALGTSKI 12 O59891 98.1% 43.0% --KKKKTKGELDERLSEIKAEFKELKKERKAKKIDPKRG-ATEEKLLAQIARIDERIATAKVQLQDRDKLKDVALGTSKI 13 TOP1_SCHPO 98.1% 41.0% --KSMLPESELEVRLKAADELKKALDAELKSKKVDPGRS--SMEQLEKRLNKLNERINVMRTQMIDKDENKTTALGTSKI 14 O13463 98.1% 39.7% --EKEMKASELETRLEAVKELEKKFNKENKTGKVEAEGRSPTVEKLEASITKLQQRIENMELQAQDKEDNKEVALGTSKI 15 CAU41342_1 98.1% 39.9% --KPLLTESDIKDKLDKIDELEKEYQKELKTGKPIVTKNA-TVEKLKQQIETLENKILNVSIQLKDKEDNSEVSLGTSKM 16 TOP1_CANAL 98.1% 39.7% --KPLLTESDIKDKLDKIDELEKEYQKELKTGKPIVTKNA-TVEKLKQQIETLENRILNVSIQLKDKEDNSEVSLGTSKM 17 JC6519 98.1% 38.1% --EKEMKASELETRLEAVKELEKKFNKENKTGKVEAEGRSPTVEKLEASITKLQQRIENMELQAQDKEDNKEVALGTSKI 18 TOP1_ARATH 95.0% 44.7% --------------------KIRSLEPNAWEKK----------------IAQQSAKIEKMERDMHTKEDLKTVALGTSKI 19 Q94705 98.1% 43.1% ------------------DDEEEADDFKETPKKKVKRALPDSVEKCKAAIERVDTSINKWNIKKTEKDELKSVALTTSKI 20 O24307 95.0% 44.7% --------------------SKRSLTPEVLEKK----------------ISQTNAKIEKMQRDMKTKVDLKTVALGTSKI 21 P93119 97.9% 41.1% ------YKGKL-LKLIQKLRKWSETRRLSVTKK----------------IAQTNTKIEKMERDKETKEDLKTVALGTSKI 22 Q26024 99.2% 35.6% --------------------VKENMKEESCKKK---------------LIT-LIKKVELLNNQMKVRDDNKTIALGTSKI 23 TOP1_USTMA 98.1% 28.2% SIKGFKDKKQVDEELKALNETAKRLEKERKTNK--SQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKL consensus/100% ......................pt.p.......................h....t.l...p.....+.p.pphuLsTSKh consensus/90% ......................cthp.....tc................ltphpppl.phphph.s+pc.ppluLuTSKl consensus/80% ...................t.tcphp....ptK...............tlpplpppl.phphphps+--.KplALGTSKl consensus/70% ...................c.t+phch..pptK...............tlpplpppl.phchphpD+--NKplALGTSKl cov pid 641 : ] 656 1 TOP1_HUMAN 100.0% 100.0% NYLDPRITVAWCKKWG 2 TOP1_CRIGR 100.0% 98.7% NYLDPRITVAWCKKWG 3 Q12855 100.0% 100.0% NYLDPRITVAWCKKWG 4 TOP1_MOUSE 100.0% 98.9% NYLDPRITVAWCKKWG 5 Q12856 100.0% 99.5% SYLDPRITVAWCKKWG 6 P79994 100.0% 95.8% NYLDPRISVAWCKKWG 7 TOP1_XENLA 100.0% 90.7% NYLDPRISVAWCKKYG 8 TOP1_DROME 95.8% 69.3% NYLDPRISVAWCKKHD 9 Q27529 97.1% 66.5% NYIDPRITVAWCKKFE 10 TOP1_YEAST 98.1% 41.8% NYIDPRLSVVFCKKYD 11 O60013 98.1% 43.8% NYIDPRLTYAWCAKYG 12 O59891 98.1% 43.0% NYIDPRLTVAWAKKFD 13 TOP1_SCHPO 98.1% 41.0% NYIDPRLTYSFSKRED 14 O13463 98.1% 39.7% NYIDPRLTVVFSKKFK 15 CAU41342_1 98.1% 39.9% NYIDPRLIVMFSKKFD 16 TOP1_CANAL 98.1% 39.7% NYIDPRLIVMFSKKFD 17 JC6519 98.1% 38.1% NYIDPRLTVVFSKKFK 18 TOP1_ARATH 95.0% 44.7% NYLDPRITVAWCKRHE 19 Q94705 98.1% 43.1% NYIDPRITAAWAKRVG 20 O24307 95.0% 44.7% NYLDPRITVAWCKRHE 21 P93119 97.9% 41.1% NYLDPRITVAWCKRHD 22 Q26024 99.2% 35.6% NYMDPRITVAFCKKFE 23 TOP1_USTMA 98.1% 28.2% NYIDPRITLAWLKEWD consensus/100% sYhDPRl.h.a.tc.t consensus/90% NYlDPRlohsasK+at consensus/80% NYlDPRloVsasK+at consensus/70% NYlDPRlTVAasKKas