cov pid 1 [ . . . . : . . . 80 1 rras_mouse 100.0% 100.0% -ETHKLVVVGGGGVGKSALTIQFIQS----YFVSDYDPTIEDSYTKICTVDGIP-ARLDILDTAGQEEFGAMREQYMRAG 2 DMRICGENE_1-223 100.0% 48.2% -RVYKIVILGDGGVGKSAVTLQFVSH----SFLDYHDPTIEDSYQQQAVIDNEA-ALLDILDTAGQVEFTAMRDQYMRCG 3 rash_msv 99.4% 56.3% MTEYKLVVVGAKGVGKSALTIQLIQN----HFVDEYDPTIEDSYRKQVVIDGET-CLLDILDTAGQEEYSAMRDQYMRTG 4 MRAS_RAT-178 100.0% 51.8% -PTYKLVVVGDGGVGKSALTIQFFQK----IFVPDYDPTIEDSYLKHTEIDNQW-AILDVLDTAGQEEFSAMREQYMRTG 5 CEC54A12_4-202 100.0% 33.5% TSDYRVAVFGAGGVGKSSITQRFVKG----TFNENYVPTIEDTYRQVISCNQKNVCTLQITDTTGSHQFPAMQRLSISKG 6 rap2_human 98.8% 46.1% MREYKVVVLGSGGVGKSALTVQFVTG----TFIEKYDPTIEDFYRKEIEVDSSP-SVLEILDTAGTEQFASMRDLYIKNG 7 ras2_drome 100.0% 69.5% MQTYKLVVVGGGGVGKSAITIQFIQS----YFVTDYDPTIEDSYTKQCNIDDVP-AKLDILDTAGQEEFSAMREQYMRSG 8 ras3_drome 100.0% 51.5% MREYKIVVLGSGGVGKSALTVQFVQC----IFVEKYDPTIEDSYRKQVEVDGQQ-CMLEILDTAGTEQFTAMRDLYMKNG 9 RASL_CAEEL-181 100.0% 35.3% SLNRKVAVMGYPHVGKSALVLRFTQN----IFPERYESTIEDQHSKHIAAFHRD-YHLRVTDTAGQQEYTVFPRSCSLDI 10 CEC25D7_8-198 100.0% 40.1% -REFKVVVLGSGGVGKSALTVQFVSS----TFIEKYDPTIEDFYRKEIEVDGQP-SVLEILDTAGTEQFSSMRDLYIKNG 11 HSRRRGBP_1-170 100.0% 34.3% -KSRKIAILGYRSVGKSSLTIQFVEG----QFVDSYDPTIENTFTKLITVNGQE-YHLQLVDTAGQDEYSIFPQTYSIDI 12 EH052_1-169 100.0% 41.6% -KDYKIVVLGSGAVGKSSITVRFVQG----IFLVKYDPTIEDSYRKQLDLDGQQ-YVLEILDTAGTEQFTAMRDLYMKTG 13 ras_schpo 100.0% 64.1% LREYKLVVVGDGGVGKSALTIQLIQS----HFVDEYDPTIEDSYRKKCEIDGEG-AVLDLLDTAGQEEYSAMREQYMRTG 14 rasa_dicdi 98.8% 56.6% MTEYKLVIVGGGGVGKSALTIQLIQN----HFIDEYDPTIEDSYRKQVSIDDET-CLLDILDTAGQEEYSAMRDQYMRTG 15 DMRAS3_1-166 99.4% 37.3% -REYKIVVLGSGGVGKSALTVQFVQC----IFVEKYDPTIEDSYRKQVKVNERQ-CMLEIVNTAGTEQFTAMRNLYMKNG 16 rasb_dicdi 99.4% 58.2% --EYKLVVMGGGGVGKSALTIQFIQN----HFIEEYDPTIEDSYRRQCQVDEDT-CLLDILDTAGQDDYSAMRDQYMRTG 17 rasc_dicdi 98.2% 53.7% ----KLVIVGDGGVGKSALTIQLTQN----QFIAEYDPTIENSYRKQVNIDEEV-YMLDILDTAGQEEYSAMRDQYIRSG 18 CE56930_1-181 100.0% 67.5% -AVLRIVVVGGGGVGKSALTIQFIQR----YFVQDYDPTIEDSYTKQCFVDEDL-CKLEILDTAGQEEFSTMREQYLRTG 19 MMAF9246_1-202 100.0% 34.5% KNCYRMVILGSSKVGKTAIVSRFLTG----RFEDAYTPTIEDFHRKFYSIRGEV-YQLDILDTSGNHPFPAMRRLSILTG 20 MMU71205_1-185 100.0% 52.4% -REYKLVMLGAGGVGKSAMTMQFISH----RFPEDHDPTIEDAYKIRIRIDDEP-ANLDILDTAGQAEFTAMRDQYMRAG 21 rasg_dicdi 100.0% 57.5% MTEYKLVIVGGGGVGKSALTIQLIQN----HFIDEYDPTIEDSYRKQVTIDEET-CLLDILDTAGQEEYSAMRDQYMRTG 22 CEF17C8_2-182 100.0% 51.8% -PYYKLVVIGDGGVGKSSLTIQFFQK----QFVDYYDPTIEDQYIQHCEIDGNW-VIMDVLDTAGQEEFSAMREQYIRGG 23 ras1_rhira 100.0% 61.7% VREYKLVMVGGGGVGKSALTIQFIQS----HFVDEYDPTIEDSYRKQCVIDSET-ALLDVLDTAGQEEYSAMREQYMRNG 24 rsr1_yeast 97.6% 50.6% MRDYKLVVLGAGGVGKSCLTVQFVQG----VYLDTYDPTIEDSYRKTIEIDNKV-FDLEILDTAGIAQFTAMRELYIKSG 25 ras2_rhira 92.8% 55.8% -------------VGKSAMTIQFIQS----TFVDEYDPTIEDSYRKQCLIDSEC-AMLDILDTAGQEEYSAMRERFMRNG 26 RAS2_HYDMA-172 100.0% 64.5% -RQYKLVVVGGGGVGKSALTIQFIQS----HFVQDYDPTIEDSYRKQCVIDDKV-AHLDILDTAGQEEFSAMRDEYMRTG 27 RSR1_CANAL-168 100.0% 47.9% -RDYKVVVLGAGGVGKSSITVQFVQG----VYVESYDPTIEDSYRKQIEVDGRA-CDLEILDTAGVAQFTAMRELYIKSG 28 rtc1_human 100.0% 69.9% -EKYRLVVVGGGGVGKSALTIQFIQS----YFVTDYDPTIEDSYTKQCVIDDRA-ARLDILDTAGQEEFGAMREQYMRTG 29 HSU78164_1-184 100.0% 51.2% -REYKVVMLGAGGVGKSAMTMQFISH----QFPDYHDPTIEDAYKTQVRIDNEP-AYLDILDTAGQAEFTAMREQYMRGG 30 rass_dicdi 100.0% 53.9% MFNFKLVLVGPGGVGKSCLTIQFIAQ----KFVDEYDPTLEDSYRKQTTVDGEE-CLLDIYDTAGQEDFSAVRDQYMRTG 31 rala_human 100.0% 49.1% LALHKVIMVGSGGVGKSALTLQFMYD----EFVEDYEPTKADSYRKKVVLDGEE-VQIDILDTAGQEDYAAIRDNYFRSG 32 RAS2_NEUCR-191 100.0% 43.8% -VLYKLVVLGDGGVGKTALTIQLCLE----HFVETYDPTIEDSYRKQVVIDGQA-CMLEVLDTAGQEEYTALRDQRIRDG 33 ras1_yeast 100.0% 58.7% IREYKIVVVGGGGVGKSALTIQFIQS----YFVDEYDPTIEDSYRKQVVIDDKV-SILDILDTAGQEEYSAMREQYMRTG 34 EH054_1-172 100.0% 47.3% -NTYKLVMLGGGAVGKSAITVQLVSG----HFVQIYDPTIEDSYRTSISVDGEM-VSLDILDTAGQEEYSALRDQYMRSG 35 RAS1_NEUCR-177 100.0% 61.1% TREYKLVVVGGGGVGKSCLTIQLIQG----HFLDEYDPTIEDSYRKQCTIDNEV-ALLDILDTAGQEEYSAMREQYMRTG consensus/100% .............VGKoshs.phh.t.....a...a.sThts.a...h.h.t.....hplhsTsG...as.h.p....th consensus/90% ...h+lshhGssuVGKSulThphhpt.....F.p.Y-PTIEDtYpp.h.lstp..h.L-llDTAGptpasuhRc.hhpsG consensus/80% ..paKlVllGsGGVGKSulTlQhlpt....hFlppYDPTIEDoYpKph.lDsp..shL-ILDTAGpcpaoAMR-.Yh+sG consensus/70% .ppYKlVllGuGGVGKSALTlQFlps....hFl-cYDPTIEDSY+KphtlDscs.shL-ILDTAGQE-aoAMR-pYh+sG cov pid 81 . 1 . . . . : . 160 1 rras_mouse 100.0% 100.0% NGFLLVFAIND-RQSFNEVGKLFTQILRVKDR-------------------DDFPIVLVGNKADLENQ-RQVLR-SEASS 2 DMRICGENE_1-223 100.0% 48.2% EGFIICYSVTD-RHSFQEASEYRKLITRVRLS-------------------EDIPLVLIANKVDLESQ-RRVTT-EEGRN 3 rash_msv 99.4% 56.3% EGFLCVFAINN-TKSFEDIHQYREQIKRVKDS-------------------DDVPMVLVGNKCDLAA--RTVES-RQAQD 4 MRAS_RAT-178 100.0% 51.8% DGFLIVYSVTD-KASFEHVDRFHQLILRVKDR-------------------ESFPMILVANKVDLMHL-RKITR-DQGKE 5 CEC54A12_4-202 100.0% 33.5% NAFILIYSVTN-KQSFAELVPIIEMMKEVKGN-----------------AIAETPIMLVGNKKDEESK-REVSS-NSGQK 6 rap2_human 98.8% 46.1% QGFILVYSLVN-QQSFQDIKPMRDQIIRVKRY-------------------EKVPVILVGNKVDLESE-REVSS-SEGRA 7 ras2_drome 100.0% 69.5% EGFLLVFALND-HSSFDEIPKFQRQILRVKDR-------------------DEFPMLMVGNKCDLKHQ-QQVSL-EEAQN 8 ras3_drome 100.0% 51.5% QGFVLVYSITA-QSTFNDLQDLREQILRVKDT-------------------DDVPMVLVGNKCDLEEE-RVVGK-ELGKN 9 RASL_CAEEL-181 100.0% 35.3% NGFILVYAIDD-RKSFEMCSNIYEKIVRTYGD-------------------TSIPIVIVGNKTDLSTQ-RVVRA-EEGEE 10 CEC25D7_8-198 100.0% 40.1% QGFVVVYSITS-QQTFHDIRNMKEQIVRVKGS-------------------ENVPILLVGNKCDLSHQ-RQVRS-EEGLA 11 HSRRRGBP_1-170 100.0% 34.3% NGYILVYSVTS-IKSFEVIKVIHGKLLDMVGK-------------------VQIPIMLVGNKKDLHME-RVISY-EEGKA 12 EH052_1-169 100.0% 41.6% QGFVLVYSIMA-QSTYNDLDPIHDQIVRVRDT-------------------ENVPIIVVGNKCDLESQ-RIVSQ-DDGKA 13 ras_schpo 100.0% 64.1% QGFLLVYNITS-RSSFDEISTFYQQILRVKDK-------------------DTFPVVLVANKCDLEAE-RVVSR-REREQ 14 rasa_dicdi 98.8% 56.6% QGFLCVYSITS-RSSYDEIASFREQILRVKDK-------------------DRVPLILVGNKADLDHE-RQVSV-NEGQE 15 DMRAS3_1-166 99.4% 37.3% SDSCWSTRSRR-NRRLTICRTREQILRVKDTD--------------------DVPMVLVGNKCDLEEE-RVVGK-ELGKN 16 rasb_dicdi 99.4% 58.2% QGFLCVYDVTS-RTSFEEINVVREQIIRVKDN-------------------DKVPIVLVGNKCDLENL-REVTE-GEGSE 17 rasc_dicdi 98.2% 53.7% RGFLIVYSIIS-RASFEAVTTFREQILRVKDL-------------------STYPIVIIGNKADLPDKDRKVPP-MEGKE 18 CE56930_1-181 100.0% 67.5% SGFLIVFAVTD-RNSFEEVKKLHELICRIKDR-------------------DDFPIILVGNKADLENE-RHVAR-HEAEE 19 MMAF9246_1-202 100.0% 34.5% DVFILVFSLDN-RDSFEEVQRLKQQILDTKSC-----------LKNKTKENVDVPLVICGNKGDRDFY-REVEQ-REIEQ 20 MMU71205_1-185 100.0% 52.4% EGFIICYSITD-RRSFHEVREFKQLIYRVRRT-------------------DDTPVVLVGNKSDLKQL-RQVSK-EEGLS 21 rasg_dicdi 100.0% 57.5% QGFLCVYSITS-RSSFDEIASFREQILRVKDK-------------------DRVPMIVVGNKCDLESD-RQVTT-GEGQD 22 CEF17C8_2-182 100.0% 51.8% RGFLLVFSVTE-RKSFEEAHKLYNQVLRVKDR-------------------SEYPVLLVANKVDLINQ-RVVSE-QEGRE 23 ras1_rhira 100.0% 61.7% EGFLLVYSITS-RLSFEEITTFYQQICRVKDR-------------------DYFPMVLVGNKCDLEGD-RQVSS-QEGRD 24 rsr1_yeast 97.6% 50.6% MGFLLVYSVTD-RQSLEELMELREQVLRIKDS-------------------DRVPMVLIGNKADLIN--ERVISVEEGIE 25 ras2_rhira 92.8% 55.8% EGFVLIYSITS-YHTFEQVQKLHEQIARVKDL-------------------EHFPMVLVGNKCDLEQD-RQVPT-SAGRD 26 RAS2_HYDMA-172 100.0% 64.5% EGFLLVFSVTD-RSSFDEIPRFHTQILRVKDI-------------------EEFPMILVGNKSDLENE-RTVST-AEAQE 27 RSR1_CANAL-168 100.0% 47.9% KGFLLVYSVTD-ENSLKELLALREQVLRIKDS-------------------DNVPMVLVGNKCDLEDD-RVLSI-EDGVK 28 rtc1_human 100.0% 69.9% EGFLLVFSVTD-RGSFEEIYKFQRQILRVKDR-------------------DEFPMILIGNKADLDHQ-RQVTQ-EEGQQ 29 HSU78164_1-184 100.0% 51.2% EGFIICYSVTD-RQSFQEAAKFKELIFQVRHT-------------------YEIPLVLVGNKIDLEQF-RQVST-EEGLS 30 rass_dicdi 100.0% 53.9% EGFLCVYSITY-LQSFKEIHRLHNHLLKVKDL-------------------DSVPFVLVGNKCDLNEY-REVST-AEGEE 31 rala_human 100.0% 49.1% EGFLCVFSITE-MESFAATADFREQILRVKED-------------------ENVPFLLVGNKSDLEDK-RQVSV-EEAKN 32 RAS2_NEUCR-191 100.0% 43.8% EGFVLVYSISS-RSSFARIKKFHHQIQRVKESTSSPSAYPGSSPLAATNPSAPVPIMLVGNKSDRVTE-REVST-QEGHA 33 ras1_yeast 100.0% 58.7% EGFLLVYSVTS-RNSFDELLSYYQQIQRVKDS-------------------DYIPVVVVGNKLDLENE-RQVSY-EDGLR 34 EH054_1-172 100.0% 47.3% DGYVIVYSITS-TTSFLEANGFREQLYRVLDKDVS----------------EHVSIALCGNKYDLENE-RQVET-AEAKK 35 RAS1_NEUCR-177 100.0% 61.1% EGFLLVFAINS-RESFEEIRIYQQQILRVKDR-------------------DSFPMIIVGNKYDLRGE-RVVSE-QEGQA consensus/100% .s.hh.ht......ph..h..h.t.h..h........................hshhhhuNK.D.....p.l.....h.t consensus/90% pGFlhsaulsp..toatth..h.p.lhchct.....................phPhhlluNK.DL.t..R.V...tpu.t consensus/80% pGFllVaulss.ppSFpcltthppplhRV+cp...................pphPhllVGNKsDLpp..R.Vst.p-upp consensus/70% pGFllVaSlos.ppSFp-ltphcpQIhRVK-p...................-phPhlLVGNKsDLcpp.RpVsp.pEGpp cov pid 161 . . . 2 . . ] 225 1 rras_mouse 100.0% 100.0% FSASHH-------------------------------MTYFEASAKLRLNVDEAFEQLVRAVRKY 2 DMRICGENE_1-223 100.0% 48.2% LANQFG-------------------------------CPFFETSAALRHYIDEAFYTLVREIRRK 3 rash_msv 99.4% 56.3% LARSYG-------------------------------IPYIKTSAKTRQGVEDAFYTLVREIRQH 4 MRAS_RAT-178 100.0% 51.8% MATKYN-------------------------------IPYIETSAKDPPLNVDKTFHDLVRVIRQ 5 CEC54A12_4-202 100.0% 33.5% VATNME-------------------------------CGFIETSAKNNENITELFQQLLALEKKR 6 rap2_human 98.8% 46.1% LAEEWG-------------------------------CPFMETSAKSKTMVDELFAEIVRQMN-- 7 ras2_drome 100.0% 69.5% TSRNLM-------------------------------IPYIECSAKLRVNVDQAFHELVRIVRKF 8 ras3_drome 100.0% 51.5% LATQFN-------------------------------CAFMETSAKAKVNVNDIFYDLVRQINKK 9 RASL_CAEEL-181 100.0% 35.3% LARQWD-------------------------------AKFVEITARESNRVHEVFELLLREIEIS 10 CEC25D7_8-198 100.0% 40.1% LENSKHKVFNILSNFVWEKIIFWKNRFFFKIETESWSCPFTECSAKNNQNVNVTFAEIVREMNYV 11 HSRRRGBP_1-170 100.0% 34.3% LAESWN-------------------------------AAFLESSAKENQTAVDVFRRIILEAEKM 12 EH052_1-169 100.0% 41.6% LADKYG-------------------------------AEFLEVSAKAEIRISDIFTTLIKRINAM 13 ras_schpo 100.0% 64.1% LAKSMH-------------------------------CLYVETSAKLRLNVEEAFYSLVRTIRRY 14 rasa_dicdi 98.8% 56.6% LAKDS--------------------------------LSFHESSAKSRINVEEAFYSLVREIRK- 15 DMRAS3_1-166 99.4% 37.3% LATQFN-------------------------------CAFMETSAKAKVNVNDIFYDWSGRSTRS 16 rasb_dicdi 99.4% 58.2% LAKSFS-------------------------------VPFLETSAKKRLNVDECFFEVVREIKKS 17 rasc_dicdi 98.2% 53.7% LAKSFG-------------------------------APFLETSAKSRVNVEEAFFTLVREIKRW 18 CE56930_1-181 100.0% 67.5% LAHRLS-------------------------------IPYLECSAKIRKNVDEAFFDIVRLVRKY 19 MMAF9246_1-202 100.0% 34.5% LVGDDP-----------------------------QRCAYFEISAKKNSSLDQMFRALFAMAKLP 20 MMU71205_1-185 100.0% 52.4% LAREFS-------------------------------CPFFETSAAYRYYIDDVFHALVREIRKK 21 rasg_dicdi 100.0% 57.5% LAKSFG-------------------------------SPFLETSAKIRVNVEEAFYSLVREIRKD 22 CEF17C8_2-182 100.0% 51.8% LAAQLK-------------------------------LMYIETSAKEPPVNVDAAFHELVRIVRS 23 ras1_rhira 100.0% 61.7% LAKNFG-------------------------------CQFIETSAKQRINVDEAFFEVVRDIRRY 24 rsr1_yeast 97.6% 50.6% VSSKWGR------------------------------VPFYETSALLRSNVDEVFVDLVRQI--- 25 ras2_rhira 92.8% 55.8% LAKQYN-------------------------------CQFFEASAKQNVRIQDAFHGLVREIRRS 26 RAS2_HYDMA-172 100.0% 64.5% LGRKLK-------------------------------VSYLESSAKQRINVDAAFHDLVRAIRNA 27 RSR1_CANAL-168 100.0% 47.9% VSQDWGL------------------------------VPFYETSAMYKTNVDEAFIDVVRQIMRK 28 rtc1_human 100.0% 69.9% LARQLK-------------------------------VTYMEASAKIRMNVDQAFHELVRVIRKF 29 HSU78164_1-184 100.0% 51.2% LAQEYN-------------------------------CGFFETSAALRFCIDDAFHGLVREIRKK 30 rass_dicdi 100.0% 53.9% LAKKLN-------------------------------CKFLETSAKERINVSESFYELVREVKKA 31 rala_human 100.0% 49.1% RAEQWN-------------------------------VNYVETSAKTRANVDKVFFDLMREIRAR 32 RAS2_NEUCR-191 100.0% 43.8% LARELG-------------------------------CEFTEASAKTRTNVEKAFYDVVKQLRKQ 33 ras1_yeast 100.0% 58.7% LAKQLN-------------------------------APFLETSAKQAINVDEAFYSLIRLVRDD 34 EH054_1-172 100.0% 47.3% LADEWK-------------------------------VLFFETSAKAKINITETFQALVKDIKVN 35 RAS1_NEUCR-177 100.0% 61.1% LAAEFG-------------------------------TKYIETSAKTQHNVENAFYDLVREIRKE consensus/100% h.tp...................................ahc.oAh........h....h..... consensus/90% hutpht...............................h.ahEsSAt.p..lpphF.tllt.h... consensus/80% LAppht...............................s.ahEsSAK.p.slpcsFhpll+tlpt. consensus/70% LApphs...............................ssahEoSAK.chsls-sFhplVRplcc.