Domains within Drosophila melanogaster protein A0A0B4K6W9_DROME (A0A0B4K6W9)

Hephaestus, isoform Y

Alternative representations: 1 /

Protein length898 aa
Source databaseUniProt
Identifiers A0A0B4K6W9_DROME, A0A0B4K6W9, FBPP0297632
Source gene FBgn0011224
Alternative splicing FBpp0085238, Q8IMF8_DROME, FBpp0289493, Q95UI6_DROME, FBpp0111778, Q7KRS7_DROME, A0A0B4LHY1_DROME, A0A0B4K6W9_DROME, A8JRI1_DROME, A0A0B4K6P4_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

A0A0B4K6W9_DROME is shown as heph in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for heph

Protein A0A0B4K6W9_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04075Plant hormone signal transduction

KEGG orthologous groups

KONameDescription
K14948PTBP2, NPTBpolypyrimidine tract-binding protein 2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0297632 in eggNOG.

OGTaxonomic classDescription
LKOG1190All organisms (root)polypyrimidine tract-binding protein 2,polypyrimidine tract-binding protein 1,polypyrimidine tract-binding protein 3
FDVR9melanogaster subgroup (species subgroup)polypyrimidine tract-binding protein 1
FV2J4melanogaster group (species group)polypyrimidine tract-binding protein 1
EJE0REndopterygota (cohort)polypyrimidine tract-binding protein 1
KOG1190Eukaryota (superkingdom)polypyrimidine tract-binding protein 2,polypyrimidine tract-binding protein 1,polypyrimidine tract-binding protein 3
HUSUUMetazoa (kingdom)polypyrimidine tract-binding protein 3,polypyrimidine tract-binding protein 1,polypyrimidine tract-binding protein 2
HIMGZArthropoda (phylum)polypyrimidine tract-binding protein 1
85RUKHexapoda (subphylum)polypyrimidine tract-binding protein 1
AGRAWNeoptera (infraclass)polypyrimidine tract-binding protein 1
ANWQFDiptera (order)polypyrimidine tract-binding protein 1
7I3XGOpisthokonta (clade)polypyrimidine tract-binding protein 3,polypyrimidine tract-binding protein 1,polypyrimidine tract-binding protein 2
H44TSBilateria (clade)polypyrimidine tract-binding protein 3,polypyrimidine tract-binding protein 1,polypyrimidine tract-binding protein 2
EH2CDDrosophila (genus)polypyrimidine tract-binding protein 1
50IGDSophophora (subgenus)polypyrimidine tract-binding protein 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: