Domains within Drosophila melanogaster protein A0A0B4KGE1_DROME (A0A0B4KGE1)

Signal transducer and activator of transcription

Alternative representations: 1 /

Protein length818 aa
Source databaseUniProt
Identifiers A0A0B4KGE1_DROME, A0A0B4KGE1, FBPP0306651
Source gene FBgn0016917
Alternative splicing Q24151-2, FBpp0088487, A0A0B4KH10_DROME, FBpp0306648, STAT_DROME, A0A0B4KGE1_DROME, A0A0B4KGI7_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

A0A0B4KGE1_DROME is shown as Stat92E in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Stat92E

Protein A0A0B4KGE1_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04630JAK-STAT signaling pathway
map05203Viral carcinogenesis

KEGG orthologous groups

KONameDescription
K11224STAT5Bsignal transducer and activator of transcription 5B

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0306651 in eggNOG.

OGTaxonomic classDescription
FDYD3melanogaster subgroup (species subgroup)signal transducer and activator of transcription 5B
FUYWImelanogaster group (species group)signal transducer and activator of transcription 5B
EIZN9Endopterygota (cohort)signal transducer and activator of transcription 5B
LKOG3667All organisms (root)signal transducer and activator of transcription 5B,signal transducer and activator of transcription 1,signal transducer and activator of transcription 3
KOG3667Eukaryota (superkingdom)signal transducer and activator of transcription 5B,signal transducer and activator of transcription 1,signal transducer and activator of transcription 3
HU8P6Metazoa (kingdom)signal transducer and activator of transcription 5B,signal transducer and activator of transcription 3,signal transducer and activator of transcription 1
HIS7RArthropoda (phylum)signal transducer and activator of transcription 5B
86GH6Hexapoda (subphylum)signal transducer and activator of transcription 5B
AHJ9CNeoptera (infraclass)signal transducer and activator of transcription 5B
AP0VRDiptera (order)signal transducer and activator of transcription 5B
7MSZPOpisthokonta (clade)signal transducer and activator of transcription 5B,signal transducer and activator of transcription 3,signal transducer and activator of transcription 1
H4SJ1Bilateria (clade)signal transducer and activator of transcription 5B,signal transducer and activator of transcription 3,signal transducer and activator of transcription 1
EH5HNDrosophila (genus)signal transducer and activator of transcription 5B
50JR7Sophophora (subgenus)signal transducer and activator of transcription 5B

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: