Domains within Rattus norvegicus protein A0A0G2JZ23_RAT (A0A0G2JZ23)

Ras-specific guanine nucleotide-releasing factor 1

Alternative representations: 1 /

Protein length1244 aa
Source databaseUniProt
Identifiers A0A0G2JZ23_RAT, A0A0G2JZ23, ENSRNOP00000070883.1, ENSRNOP00000070883
Source gene ENSRNOG00000014025
Alternative splicing F1LM43_RAT, A0A0G2JZ23_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

A0A0G2JZ23_RAT is shown as Rasgrf1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Rasgrf1

Protein A0A0G2JZ23_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04010MAPK signaling pathway
map04510Focal adhesion
map04014Ras signaling pathway

KEGG orthologous groups

KONameDescription
K09285OVM, ANTAP2-like factor, ANT lineage
K04349RASGRF1Ras-specific guanine nucleotide-releasing factor 1
K12326RASGRF2Ras-specific guanine nucleotide-releasing factor 2
K03099SOSson of sevenless

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000070883 in eggNOG.

OGTaxonomic classDescription
LKOG3417All organisms (root)AP2-like factor, ANT lineage,son of sevenless,AP2-like factor, euAP2 lineage
KOG3417Eukaryota (superkingdom)AP2-like factor, ANT lineage,son of sevenless,AP2-like factor, euAP2 lineage
HVU8UMetazoa (kingdom)Ras-specific guanine nucleotide-releasing factor 1,Ras-specific guanine nucleotide-releasing factor 2,son of sevenless
94S8TChordata (phylum)Ras-specific guanine nucleotide-releasing factor 2,Ras-specific guanine nucleotide-releasing factor 1,creatine kinase [EC:2.7.3.2]
5QN2GSarcopterygii (superclass)Ras-specific guanine nucleotide-releasing factor 2,Ras-specific guanine nucleotide-releasing factor 1,creatine kinase [EC:2.7.3.2]
8Z46EMammalia (class)Ras-specific guanine nucleotide-releasing factor 2,Ras-specific guanine nucleotide-releasing factor 1,creatine kinase [EC:2.7.3.2]
4RAN5Euarchontoglires (superorder)Ras-specific guanine nucleotide-releasing factor 1,Ras-specific guanine nucleotide-releasing factor 2
AIAP5Rodentia (order)Ras-specific guanine nucleotide-releasing factor 1,Ras-specific guanine nucleotide-releasing factor 2
8D429Myomorpha (suborder)Ras-specific guanine nucleotide-releasing factor 1
H4D8HBilateria (clade)Ras-specific guanine nucleotide-releasing factor 1,Ras-specific guanine nucleotide-releasing factor 2,son of sevenless
7HT3XOpisthokonta (clade)son of sevenless,Ras-specific guanine nucleotide-releasing factor RalGPS,Ras-specific guanine nucleotide-releasing factor 1
9FCF8Vertebrata (clade)Ras-specific guanine nucleotide-releasing factor 2,Ras-specific guanine nucleotide-releasing factor 1,creatine kinase [EC:2.7.3.2]
CQF0GMuridae (family)Ras-specific guanine nucleotide-releasing factor 1
ADYJPMurinae (subfamily)Ras-specific guanine nucleotide-releasing factor 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: