Domains within Rattus norvegicus protein A0A0G2K6Y1_RAT (A0A0G2K6Y1)

Regulator of G-protein-signaling 8

Alternative representations: 1 /

Protein length232 aa
Source databaseUniProt
Identifiers A0A0G2K6Y1_RAT, A0A0G2K6Y1, ENSRNOP00000073985.1, ENSRNOP00000073985
Source gene ENSRNOG00000002369
Alternative splicing A0A0G2K6Y1_RAT, RGS8_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

A0A0G2K6Y1_RAT is shown as Rgs8 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Rgs8

Protein A0A0G2K6Y1_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05225Hepatocellular carcinoma

KEGG orthologous groups

KONameDescription
K16449RGSregulator of G-protein signaling

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000073985 in eggNOG.

OGTaxonomic classDescription
LKOG3589All organisms (root)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
KOG3589Eukaryota (superkingdom)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
HU11CMetazoa (kingdom)regulator of G-protein signaling
94GAMChordata (phylum)regulator of G-protein signaling
5QP46Sarcopterygii (superclass)regulator of G-protein signaling
8Z6U5Mammalia (class)regulator of G-protein signaling
4RHK7Euarchontoglires (superorder)regulator of G-protein signaling
AIF9ARodentia (order)regulator of G-protein signaling
8D5FXMyomorpha (suborder)regulator of G-protein signaling
H53SNBilateria (clade)regulator of G-protein signaling
7GDS8Opisthokonta (clade)regulator of G-protein signaling
9GDS5Vertebrata (clade)regulator of G-protein signaling
CQ0DAMuridae (family)regulator of G-protein signaling
AE558Murinae (subfamily)regulator of G-protein signaling

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: