Domains within Danio rerio protein A0A0R4ISG3_DANRE (A0A0R4ISG3)

O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1

Alternative representations: 1 /

Protein length1062 aa
Source databaseUniProt
Identifiers A0A0R4ISG3_DANRE, A0A0R4ISG3, ENSDARP00000137847.1, ENSDARP00000137847, A0A0R4IEZ5_DANRE, A0A0R4IEZ5
Source gene ENSDARG00000105243
Alternative splicing ENSDARP00000134118.1, A0A0R4IJA3_DANRE, A0A0R4ISG3_DANRE, A0A0R4IP04_DANRE, B3DKP3_DANRE, A0A0R4IYQ8_DANRE, ENSDARP00000154706.1, ENSDARP00000145336.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

A0A0R4ISG3_DANRE is shown as ogt.1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ogt.1

Protein A0A0R4ISG3_DANRE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04931Insulin resistance

KEGG orthologous groups

KONameDescription
K09667OGTprotein O-GlcNAc transferase [EC:2.4.1.255]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 22 PTMs annotated in this protein:

PTMCount
Ubiquitination10
Phosphorylation8
SUMOylation3
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ogt.1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7955.ENSDARP00000137847 in eggNOG.

OGTaxonomic classDescription
9IX3ROtomorpha (cohort)protein O-GlcNAc transferase [EC:2.4.1.255]
LCOG3914All organisms (root)protein O-GlcNAc transferase [EC:2.4.1.255],tetratricopeptide repeat protein 6,CRISPR-associated protein Csy1
KOG4626Eukaryota (superkingdom)protein O-GlcNAc transferase [EC:2.4.1.255],tetratricopeptide repeat protein 6,tetratricopeptide repeat protein 17
HUAG1Metazoa (kingdom)protein O-GlcNAc transferase [EC:2.4.1.255],E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
94W5BChordata (phylum)protein O-GlcNAc transferase [EC:2.4.1.255]
FYFIMActinopterygii (superclass)protein O-GlcNAc transferase [EC:2.4.1.255]
8NREFNeopterygii (subclass)protein O-GlcNAc transferase [EC:2.4.1.255]
7JWSROpisthokonta (clade)protein O-GlcNAc transferase [EC:2.4.1.255],E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
H5BJIBilateria (clade)protein O-GlcNAc transferase [EC:2.4.1.255],E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
9GT5FVertebrata (clade)protein O-GlcNAc transferase [EC:2.4.1.255]
BESRCCyprinidae (family)protein O-GlcNAc transferase [EC:2.4.1.255]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: