Domains within Drosophila melanogaster protein A1ZBL0_DROME (A1ZBL0)

Tubulin beta chain

Alternative representations: 1 /

Protein length456 aa
Source databaseUniProt
Identifiers A1ZBL0_DROME, A1ZBL0, FBPP0085721, Q6XIS6_DROYA, Q6XIS6, A0A0C9PIF3_9HYME, A0A0C9PIF3, U5LSR1_CALVI, U5LSR1, A0A0A0VB41_CHRMG, A0A0A0VB41
Source gene FBgn0284243
Alternative splicing TBB1_DROME, A1ZBL0_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

A1ZBL0_DROME is shown as betaTub56D in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for betaTub56D

Protein A1ZBL0_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K07375TUBBtubulin beta

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 59 PTMs annotated in this protein:

PTMCount
Phosphorylation38
Ubiquitination14
Acetylation4
Nitrosylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein beta-Tub56D.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0085721 in eggNOG.

OGTaxonomic classDescription
EJ09ZEndopterygota (cohort)tubulin beta
FDTV8melanogaster subgroup (species subgroup)tubulin beta
FV6WFmelanogaster group (species group)tubulin beta
LKOG1375All organisms (root)tubulin beta,centromere protein I,tubulin epsilon
KOG1375Eukaryota (superkingdom)tubulin beta,centromere protein I,tubulin epsilon
HU5VKMetazoa (kingdom)tubulin beta,tubulin epsilon,melanoma-associated antigen p97
HI7PYArthropoda (phylum)tubulin beta,tubulin epsilon
85QZQHexapoda (subphylum)tubulin beta,tubulin epsilon
AGWDMNeoptera (infraclass)tubulin beta,tubulin epsilon
ANTZNDiptera (order)tubulin beta
H3BN6Bilateria (clade)tubulin beta,tubulin epsilon,melanoma-associated antigen p97
7IK8DOpisthokonta (clade)tubulin beta,centromere protein I,tubulin epsilon
EH3M7Drosophila (genus)tubulin beta
50ECQSophophora (subgenus)tubulin beta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: