Domains within Drosophila melanogaster protein A8JQT5_DROME (A8JQT5)

Chondrocyte-derived ezrin-like domain containing protein, isoform G

Alternative representations: 1 /

Protein length4273 aa
Source databaseUniProt
Identifiers A8JQT5_DROME, A8JQT5, FBPP0307781
Source gene FBgn0265082
Alternative splicing Q2M1E6_DROME, A0A0C4DHA1_DROME, A8JQT5_DROME, Q9VN68_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

A8JQT5_DROME is shown as Cdep in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cdep

Protein A8JQT5_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04015Rap1 signaling pathway

KEGG orthologous groups

KONameDescription
K06082FARP2, FRGFERM, RhoGEF and pleckstrin domain protein 2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0307781 in eggNOG.

OGTaxonomic classDescription
LKOG3531All organisms (root)FERM, RhoGEF and pleckstrin domain protein 2,FERM, RhoGEF and pleckstrin domain-containing protein 1,FERM domain-containing protein 7
EJCBVEndopterygota (cohort)FERM, RhoGEF and pleckstrin domain protein 2
FE4KVmelanogaster subgroup (species subgroup)FERM, RhoGEF and pleckstrin domain protein 2
FUZQTmelanogaster group (species group)FERM, RhoGEF and pleckstrin domain protein 2
KOG3531Eukaryota (superkingdom)FERM, RhoGEF and pleckstrin domain protein 2,FERM, RhoGEF and pleckstrin domain-containing protein 1,FERM domain-containing protein 7
HWBZ1Metazoa (kingdom)FERM, RhoGEF and pleckstrin domain protein 2,FERM, RhoGEF and pleckstrin domain-containing protein 1,FERM domain-containing protein 7
HICPJArthropoda (phylum)FERM, RhoGEF and pleckstrin domain protein 2
866TFHexapoda (subphylum)FERM, RhoGEF and pleckstrin domain protein 2
AGPRCNeoptera (infraclass)FERM, RhoGEF and pleckstrin domain protein 2
AP374Diptera (order)FERM, RhoGEF and pleckstrin domain protein 2
H4U1RBilateria (clade)FERM, RhoGEF and pleckstrin domain protein 2,FERM, RhoGEF and pleckstrin domain-containing protein 1,FERM domain-containing protein 7
7MYUYOpisthokonta (clade)FERM, RhoGEF and pleckstrin domain protein 2,FERM, RhoGEF and pleckstrin domain-containing protein 1,FERM domain-containing protein 7
EH3QZDrosophila (genus)FERM, RhoGEF and pleckstrin domain protein 2
50P61Sophophora (subgenus)FERM, RhoGEF and pleckstrin domain protein 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: