Domains within Mus musculus protein ARF_MOUSE (Q64364)

Tumor suppressor ARF

Alternative representations: 1 /

Protein length169 aa
Source databaseUniProt
Identifiers ARF_MOUSE, Q64364, ENSMUSP00000102748.2, ENSMUSP00000102748, Q4U255, Q9QXC7, Q9R051, A7LP29_MOUSE, A7LP29, Q64364-2, Q9Z1E7_MUSSP, Q9Z1E7
Source gene ENSMUSG00000044303
Alternative splicing CDN2A_MOUSE, ARF_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

ARF_MOUSE is shown as Cdkn2a in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cdkn2a

Protein ARF_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05166Human T-cell leukemia virus 1 infection
map05225Hepatocellular carcinoma
map05203Viral carcinogenesis

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K06867K06867uncharacterized protein
K06621CDKN2A, P16, INK4Acyclin-dependent kinase inhibitor 2A

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000102748 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HV2Z7Metazoa (kingdom)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
94IG6Chordata (phylum)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
5QH3ZSarcopterygii (superclass)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
8ZNYXMammalia (class)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
4R3XBEuarchontoglires (superorder)cyclin-dependent kinase inhibitor 2A
AHXF4Rodentia (order)P19Arf_N
8DD6SMyomorpha (suborder)P19Arf_N
9G1C0Vertebrata (clade)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
7MWGROpisthokonta (clade)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
H4022Bilateria (clade)cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinase inhibitor 2A
CQDR2Muridae (family)P19Arf_N
ADXD8Murinae (subfamily)P19Arf_N
5PJS0Mus (genus)P19Arf_N
HEGC5Mus (subgenus)P19Arf_N

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: