Domains within Homo sapiens protein ATM_HUMAN (Q13315)

Serine-protein kinase ATM

Alternative representations: 1 /

Protein length3056 aa
Source databaseUniProt
Identifiers ATM_HUMAN, Q13315, ENSP00000388058.2, ENSP00000388058, ENSP00000278616.4, ENSP00000278616, B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7, E9PIN0_HUMAN, E9PIN0, M0QXY8_HUMAN, M0QXY8, A0A2J8X287_PONAB, A0A2J8X287, E9PRG7_HUMAN, E9PRG7, A0A2J8L0Q0_PANTR, A0A2J8L0Q0, A0A024R3C7_HUMAN, A0A024R3C7
Source gene ENSG00000149311
Alternative splicing ENSP00000435747.1, E9PIQ5_HUMAN, ENSP00000432318.1, A0A087X0E9_HUMAN, ATM_HUMAN, Q6P7P1_HUMAN, ENSP00000469471.1, ENSP00000434327.2, H0YEC6_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

ATM_HUMAN is shown as ATM in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ATM

Protein ATM_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05206MicroRNAs in cancer

KEGG orthologous groups

KONameDescription
K04728ATM, TEL1serine-protein kinase ATM [EC:2.7.11.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000278616 in eggNOG.

OGTaxonomic classDescription
LKOG0892All organisms (root)serine-protein kinase ATM [EC:2.7.11.1]
KOG0892Eukaryota (superkingdom)serine-protein kinase ATM [EC:2.7.11.1]
HTAXTMetazoa (kingdom)serine-protein kinase ATM [EC:2.7.11.1]
94TWEChordata (phylum)serine-protein kinase ATM [EC:2.7.11.1]
5QY9SSarcopterygii (superclass)serine-protein kinase ATM [EC:2.7.11.1]
8Z6GGMammalia (class)serine-protein kinase ATM [EC:2.7.11.1]
4RRH1Euarchontoglires (superorder)serine-protein kinase ATM [EC:2.7.11.1]
504QSPrimates (order)serine-protein kinase ATM [EC:2.7.11.1]
98KYUHaplorrhini (suborder)serine-protein kinase ATM [EC:2.7.11.1]
BVAYWSimiiformes (infraorder)serine-protein kinase ATM [EC:2.7.11.1]
9EVQICatarrhini (parvorder)serine-protein kinase ATM [EC:2.7.11.1]
9GIAYVertebrata (clade)serine-protein kinase ATM [EC:2.7.11.1]
7HTV0Opisthokonta (clade)serine-protein kinase ATM [EC:2.7.11.1]
H4I9HBilateria (clade)serine-protein kinase ATM [EC:2.7.11.1]
FWYM7Hominoidea (superfamily)serine-protein kinase ATM [EC:2.7.11.1]
5MXT2Hominidae (family)serine-protein kinase ATM [EC:2.7.11.1]
5Y370Homininae (subfamily)serine-protein kinase ATM [EC:2.7.11.1]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: