Domains within Mus musculus protein B7FAU9_MOUSE (B7FAU9)

Filamin, alpha

Alternative representations: 1 /

Protein length2639 aa
Source databaseUniProt
Identifiers B7FAU9, B7FAU9_MOUSE, ENSMUSP00000109938.1, ENSMUSP00000109938, ENSMUSP00000098997.2, ENSMUSP00000098997
Source gene ENSMUSG00000031328
Alternative splicing F6XC15_MOUSE, B7FAU9_MOUSE, FLNA_MOUSE, B7FAV1_MOUSE, J3JS91_MOUSE, F7AVL7_MOUSE, F6Z2C0_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

B7FAU9_MOUSE is shown as Flna in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Flna

Protein B7FAU9_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04510Focal adhesion

KEGG orthologous groups

KONameDescription
K04437FLNAfilamin-A

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000109938 in eggNOG.

OGTaxonomic classDescription
LKOG0518All organisms (root)filamin,neuron navigator 3,neuron navigator 2 [EC:5.6.2.4]
KOG0518Eukaryota (superkingdom)filamin,neuron navigator 3,neuron navigator 2 [EC:5.6.2.4]
HTNKNMetazoa (kingdom)filamin,tensin
94VPQChordata (phylum)filamin
5R634Sarcopterygii (superclass)filamin
8Z67SMammalia (class)filamin
4REIPEuarchontoglires (superorder)filamin
AIBCSRodentia (order)filamin
8DJCXMyomorpha (suborder)filamin
H60DKBilateria (clade)filamin,tensin
7JV2IOpisthokonta (clade)filamin,tensin
9FVY2Vertebrata (clade)filamin
CQ8REMuridae (family)filamin
ADXCTMurinae (subfamily)filamin
5PP37Mus (genus)filamin
HEC89Mus (subgenus)filamin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: