Domains within Mus musculus protein CAD16_MOUSE (O88338)

Cadherin-16

Alternative representations: 1 /

Protein length830 aa
Source databaseUniProt
Identifiers CAD16_MOUSE, O88338, ENSMUSP00000148478.1, ENSMUSP00000148478, Q9JLZ5, Q546A8_MOUSE, Q546A8, A0A1D5RMI6_MOUSE, A0A1D5RMI6
Source gene ENSMUSG00000031881
Alternative splicing A0A1D5RLE7_MOUSE, Q8C730_MOUSE, CAD16_MOUSE, A0A1D5RLG9_MOUSE, Q3TPA4_MOUSE, A0A1D5RMA8_MOUSE, A0A1D5RL88_MOUSE, A0A1D5RLS8_MOUSE, A0A1D5RMB7_MOUSE, A0A1D5RM27_MOUSE, A0A1D5RMM2_MOUSE, A0A1D5RMK0_MOUSE, ENSMUSP00000148793.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

CAD16_MOUSE is shown as Cdh16 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cdh16

Protein CAD16_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05226Gastric cancer
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K16499PCDHD2protocadherin delta 2
K06811CDH17cadherin 17, LI cadherin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 1 PTMs annotated in this protein:

PTMCount
Phosphorylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Cdh16.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000148478 in eggNOG.

OGTaxonomic classDescription
LKOG3594All organisms (root)protocadherin delta 2,protocadherin delta 1,protocadherin beta
KOG3594Eukaryota (superkingdom)protocadherin delta 2,protocadherin delta 1,protocadherin beta
HTA71Metazoa (kingdom)cadherin 16, KSP-cadherin,cadherin 17, LI cadherin
93YAZChordata (phylum)cadherin 16, KSP-cadherin,cadherin 17, LI cadherin
5QBF5Sarcopterygii (superclass)cadherin 16, KSP-cadherin
8YW0KMammalia (class)cadherin 16, KSP-cadherin
4RFT5Euarchontoglires (superorder)cadherin 16, KSP-cadherin
AI7CPRodentia (order)cadherin 16, KSP-cadherin
8DC6IMyomorpha (suborder)cadherin 16, KSP-cadherin
7HS63Opisthokonta (clade)cadherin 16, KSP-cadherin,cadherin 17, LI cadherin
9FXIJVertebrata (clade)cadherin 16, KSP-cadherin,cadherin 17, LI cadherin
H524KBilateria (clade)cadherin 16, KSP-cadherin,cadherin 17, LI cadherin
CQ8TTMuridae (family)cadherin 16, KSP-cadherin
AEAJGMurinae (subfamily)cadherin 16, KSP-cadherin
5PYBJMus (genus)cadherin 16, KSP-cadherin
HEC0SMus (subgenus)cadherin 16, KSP-cadherin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: