Domains within Sus scrofa protein CATH_PIG (O46427)

Pro-cathepsin H

Alternative representations: 1 /

Protein length335 aa
Source databaseUniProt
Identifiers CATH_PIG, O46427, ENSSSCP00000001934.1, ENSSSCP00000001934, B2D1T2_PIG, B2D1T2, B2D1T3_PIG, B2D1T3
Source gene ENSSSCG00000001770
Alternative splicing CATH_PIG, F1RKR7_PIG

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

CATH_PIG is shown as CTSH in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CTSH

Protein CATH_PIG is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04142Lysosome
map04210Apoptosis

KEGG orthologous groups

KONameDescription
K01366CTSHcathepsin H [EC:3.4.22.16]
K01365CTSLcathepsin L [EC:3.4.22.15]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9823.ENSSSCP00000001934 in eggNOG.

OGTaxonomic classDescription
LCOG4870All organisms (root)cathepsin L [EC:3.4.22.15],cathepsin B [EC:3.4.22.1],cathepsin F [EC:3.4.22.41]
KOG1543Eukaryota (superkingdom)cathepsin L [EC:3.4.22.15],cathepsin B [EC:3.4.22.1],cathepsin X [EC:3.4.18.1]
HTY79Metazoa (kingdom)cathepsin L [EC:3.4.22.15],cathepsin S [EC:3.4.22.27],cathepsin K [EC:3.4.22.38]
94DWUChordata (phylum)cathepsin H [EC:3.4.22.16]
5QQFGSarcopterygii (superclass)cathepsin H [EC:3.4.22.16]
8ZMK4Mammalia (class)cathepsin H [EC:3.4.22.16]
BQEF0Laurasiatheria (superorder)cathepsin H [EC:3.4.22.16]
AX7QEArtiodactyla (order)cathepsin H [EC:3.4.22.16]
9G3C7Vertebrata (clade)cathepsin H [EC:3.4.22.16]
7HTRGOpisthokonta (clade)cathepsin L [EC:3.4.22.15],cathepsin B [EC:3.4.22.1],cathepsin X [EC:3.4.18.1]
H6AWSBilateria (clade)cathepsin L [EC:3.4.22.15],cathepsin S [EC:3.4.22.27],cathepsin K [EC:3.4.22.38]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: