Domains within Homo sapiens protein CHSP1_HUMAN (Q9Y2V2)

Calcium-regulated heat-stable protein 1

Alternative representations: 1 /

Protein length147 aa
Source databaseUniProt
Identifiers CHSP1_HUMAN, Q9Y2V2, ENSP00000379838.2, ENSP00000379838, ENSP00000311847.4, ENSP00000311847, ENSP00000455284.1, ENSP00000455284, ENSP00000455855.1, ENSP00000455855, ENSP00000481550.1, ENSP00000481550, ENSP00000483591.1, ENSP00000483591, ENSP00000480144.1, ENSP00000480144, ENSP00000478055.1, ENSP00000478055, ENSP00000480542.1, ENSP00000480542, B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, H3BPY5_HUMAN, H3BPY5, H3BSW7_HUMAN, H3BSW7, A0A2J8LA32_PANTR, A0A2J8LA32, H2QAJ7_PANTR, H2QAJ7, G3R0K0_GORGO, G3R0K0, H3BNU9_HUMAN, H3BNU9, A0A2J8LA52_PANTR, A0A2J8LA52, H3BUY4_HUMAN, H3BUY4, A0A2J8LA17_PANTR, A0A2J8LA17, A0A2J8LA44_PANTR, A0A2J8LA44, H3BTK3_HUMAN, H3BTK3, A0A2J8LA35_PANTR, A0A2J8LA35
Source gene ENSG00000153048
Alternative splicing CHSP1_HUMAN, ENSP00000455016.1, ENSP00000455522.1, ENSP00000457864.1, ENSP00000456909.1, H3BQY0_HUMAN, I3L3X8_HUMAN, ENSP00000457213.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

CHSP1_HUMAN is shown as CARHSP1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CARHSP1

Protein CHSP1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04530Tight junction

KEGG orthologous groups

KONameDescription
K03704cspAcold shock protein
K18754LIN28protein lin-28

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 20 PTMs annotated in this protein:

PTMCount
Phosphorylation17
Acetylation2
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein CARHSP1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000379838 in eggNOG.

OGTaxonomic classDescription
LCOG1278All organisms (root)cold shock protein,protein lin-28,Y-box-binding protein 1
KOG3070Eukaryota (superkingdom)protein lin-28,Y-box-binding protein 1,cellular nucleic acid-binding protein
HTMEZMetazoa (kingdom)CSD
94V03Chordata (phylum)CSD
5R6IUSarcopterygii (superclass)CSD
8ZI6BMammalia (class)CSD
4RAW4Euarchontoglires (superorder)CSD
4ZPYXPrimates (order)CSD
988FSHaplorrhini (suborder)CSD
BV7RZSimiiformes (infraorder)CSD
9EPB6Catarrhini (parvorder)CSD
H6EJTBilateria (clade)CSD
9GUU7Vertebrata (clade)CSD
7K95NOpisthokonta (clade)CSD
FWZGGHominoidea (superfamily)CSD
5MZC7Hominidae (family)CSD
5Y089Homininae (subfamily)CSD

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: