Domains within Homo sapiens protein CLC2B_HUMAN (Q92478)

C-type lectin domain family 2 member B

Alternative representations: 1 /

Protein length149 aa
Source databaseUniProt
Identifiers CLC2B_HUMAN, Q92478, ENSP00000228438.2, ENSP00000228438, B2R9U1, Q8IZE9, Q9BS74, Q9UQB4, H2Q5E6_PANTR, H2Q5E6
Source gene ENSG00000110852
Alternative splicing CLC2B_HUMAN, F5H631_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

CLC2B_HUMAN is shown as CLEC2B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CLEC2B

Protein CLC2B_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04145Phagosome
map05167Kaposi sarcoma-associated herpesvirus infection

KEGG orthologous groups

KONameDescription
K06560MRC, CD206, CD280mannose receptor, C type
K10071CLEC2BC-type lectin domain family 2 member B
K06502CD69CD69 antigen
K10072CLEC2DC-type lectin domain family 2 member D

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000228438 in eggNOG.

OGTaxonomic classDescription
LKOG4297All organisms (root)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
KOG4297Eukaryota (superkingdom)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
HVHZ4Metazoa (kingdom)mannose receptor, C type,regenerating islet-derived protein 4,8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
93EE7Chordata (phylum)C-type lectin domain family 2 member D,CD69 antigen,C-type lectin domain family 2 member B
5QTWPSarcopterygii (superclass)C-type lectin domain family 2 member D,CD69 antigen,C-type lectin domain family 2 member B
8YXA2Mammalia (class)C-type lectin domain family 2 member D,C-type lectin domain family 2 member B,CD69 antigen
4RB16Euarchontoglires (superorder)C-type lectin domain family 2 member B
4ZZ92Primates (order)C-type lectin domain family 2 member B
98BGGHaplorrhini (suborder)C-type lectin domain family 2 member B
BUZI0Simiiformes (infraorder)C-type lectin domain family 2 member B
9EYYACatarrhini (parvorder)C-type lectin domain family 2 member B
9G6M6Vertebrata (clade)C-type lectin domain family 2 member D,CD69 antigen,C-type lectin domain family 2 member B
7MCFYOpisthokonta (clade)mannose receptor, C type,regenerating islet-derived protein 4,8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
H4KPABilateria (clade)C-type lectin domain family 2 member D,CD69 antigen,C-type lectin domain family 2 member B
FX8DKHominoidea (superfamily)C-type lectin domain family 2 member B
5MXRSHominidae (family)C-type lectin domain family 2 member B
5XVA6Homininae (subfamily)C-type lectin domain family 2 member B

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: