Domains within Homo sapiens protein DAAM1_HUMAN (Q9Y4D1)

Disheveled-associated activator of morphogenesis 1

Alternative representations: 1 /

Protein length1078 aa
Source databaseUniProt
Identifiers Q9Y4D1, DAAM1_HUMAN, ENSP00000378557.1, ENSP00000378557, Q86U34, Q8N1Z8, Q8TB39, A0A2I3SJQ7_PANTR, A0A2I3SJQ7
Source gene ENSG00000100592
Alternative splicing ENSP00000354162.3, G3V275_HUMAN, DAAM1_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

DAAM1_HUMAN is shown as DAAM1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DAAM1

Protein DAAM1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04310Wnt signaling pathway

KEGG orthologous groups

KONameDescription
K04512DAAMdishevelled associated activator of morphogenesis

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 24 PTMs annotated in this protein:

PTMCount
Phosphorylation17
Acetylation6
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein DAAM1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000378557 in eggNOG.

OGTaxonomic classDescription
LKOG1922All organisms (root)dishevelled associated activator of morphogenesis,formin 2,formin 1
KOG1922Eukaryota (superkingdom)dishevelled associated activator of morphogenesis,formin 2,formin 1
HSXV0Metazoa (kingdom)dishevelled associated activator of morphogenesis,inverted formin-2
94DQWChordata (phylum)dishevelled associated activator of morphogenesis
5RBZ1Sarcopterygii (superclass)dishevelled associated activator of morphogenesis
8ZFG0Mammalia (class)dishevelled associated activator of morphogenesis
4R7RYEuarchontoglires (superorder)dishevelled associated activator of morphogenesis
4ZR4WPrimates (order)dishevelled associated activator of morphogenesis
98RVYHaplorrhini (suborder)dishevelled associated activator of morphogenesis
BV9A2Simiiformes (infraorder)dishevelled associated activator of morphogenesis
9EIAFCatarrhini (parvorder)dishevelled associated activator of morphogenesis
H4MWMBilateria (clade)dishevelled associated activator of morphogenesis,inverted formin-2
7HEDGOpisthokonta (clade)dishevelled associated activator of morphogenesis,cytokinesis protein,inverted formin-2
9FQ23Vertebrata (clade)dishevelled associated activator of morphogenesis
FX1V8Hominoidea (superfamily)dishevelled associated activator of morphogenesis
5N51GHominidae (family)dishevelled associated activator of morphogenesis
5Y4DSHomininae (subfamily)dishevelled associated activator of morphogenesis

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: