Domains within Homo sapiens protein ENSP00000256858.5

Alternative representations: 1 /

Protein length1250 aa
Source databaseEnsembl
Identifiers ENSP00000256858.5, ENSP00000256858
Source gene ENSG00000134444
Alternative splicing ENSP00000494314.1, ENSP00000256858.5, K1468_HUMAN, A0A075B785_HUMAN, A0A075B768_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000256858.5 is shown as RELCH in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RELCH

Protein ENSP00000256858.5 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04350TGF-beta signaling pathway
map05323Rheumatoid arthritis

KEGG orthologous groups

KONameDescription
K05147TNFRSF11A, RANK, CD265tumor necrosis factor receptor superfamily member 11A
K03456PPP2R1serine/threonine-protein phosphatase 2A regulatory subunit A

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000256858 in eggNOG.

OGTaxonomic classDescription
LKOG0211All organisms (root)serine/threonine-protein phosphatase 2A regulatory subunit A,serine/threonine-protein phosphatase 4 regulatory subunit 1,formin-binding protein 4
KOG0211Eukaryota (superkingdom)serine/threonine-protein phosphatase 2A regulatory subunit A,serine/threonine-protein phosphatase 4 regulatory subunit 1,formin-binding protein 4
HVD13Metazoa (kingdom)tumor necrosis factor receptor superfamily member 11A
94GXEChordata (phylum)tumor necrosis factor receptor superfamily member 11A
5RAW6Sarcopterygii (superclass)tumor necrosis factor receptor superfamily member 11A
8Z8AAMammalia (class)tumor necrosis factor receptor superfamily member 11A
4R3EJEuarchontoglires (superorder)tumor necrosis factor receptor superfamily member 11A
4ZTYCPrimates (order)no description
98DBMHaplorrhini (suborder)no description
BVD4NSimiiformes (infraorder)no description
9EHRBCatarrhini (parvorder)no description
H4ZSWBilateria (clade)tumor necrosis factor receptor superfamily member 11A
7GB4POpisthokonta (clade)tumor necrosis factor receptor superfamily member 11A
9FWM7Vertebrata (clade)tumor necrosis factor receptor superfamily member 11A
FX0Z4Hominoidea (superfamily)no description
5N3NNHominidae (family)no description
5Y3RQHomininae (subfamily)no description

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: