Domains within Homo sapiens protein ENSP00000327048.4

Alternative representations: 1 /

Protein length403 aa
Source databaseEnsembl
Identifiers ENSP00000327048.4, ENSP00000327048
Source gene ENSG00000178573
Alternative splicing ENSP00000455097.1, ENSP00000327048.4, MAF_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000327048.4 is shown as MAF in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for MAF

Protein ENSP00000327048.4 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04928Parathyroid hormone synthesis, secretion and action
map05321Inflammatory bowel disease

KEGG orthologous groups

KONameDescription
K09037MAFF_G_Ktranscription factor MAFF/G/K
K09036MAFBtranscription factor MAFB
K09035CMAF, MAFtranscription factor Maf

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 66 PTMs annotated in this protein:

PTMCount
Phosphorylation52
SUMOylation6
Acetylation6
Ubiquitination2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein MAF.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000327048 in eggNOG.

OGTaxonomic classDescription
LKOG4196All organisms (root)transcription factor MAFF/G/K,transcription factor MAFB,transcription factor Maf
KOG4196Eukaryota (superkingdom)transcription factor MAFF/G/K,transcription factor MAFB,transcription factor Maf
HSUUIMetazoa (kingdom)transcription factor MAFB,transcription factor Maf,transcription factor MAFA
94S2RChordata (phylum)transcription factor Maf,transcription factor MAFB,transcription factor MAFA
5QG2BSarcopterygii (superclass)transcription factor Maf,transcription factor MAFB,transcription factor MAFA
8YZJKMammalia (class)transcription factor Maf,transcription factor MAFB,transcription factor MAFA
4RDIEEuarchontoglires (superorder)transcription factor Maf
4ZMAHPrimates (order)transcription factor Maf
98DXEHaplorrhini (suborder)transcription factor Maf
BUYHHSimiiformes (infraorder)transcription factor Maf
9ERPKCatarrhini (parvorder)transcription factor Maf
7KIZ2Opisthokonta (clade)transcription factor MAFB,transcription factor Maf,transcription factor MAFA
9G518Vertebrata (clade)transcription factor Maf,transcription factor MAFB,transcription factor MAFA
H3B8SBilateria (clade)transcription factor MAFB,transcription factor Maf,transcription factor MAFA
FWZIJHominoidea (superfamily)transcription factor Maf
5N00PHominidae (family)transcription factor Maf
5Y1TJHomininae (subfamily)transcription factor Maf

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: