Domains within Homo sapiens protein ENSP00000333363.7

Alternative representations: 1 /

Protein length4707 aa
Source databaseEnsembl
Identifiers ENSP00000333363.7, ENSP00000333363
Source gene ENSG00000124721
Alternative splicing ENSP00000333363.7, ENSP00000362375.4, H0Y7V4_HUMAN, DYH8_HUMAN, H3BLZ4_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000333363.7 is shown as DNAH8 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DNAH8

Protein ENSP00000333363.7 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K10408DNAHdynein axonemal heavy chain

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000333363 in eggNOG.

OGTaxonomic classDescription
LKOG3595All organisms (root)dynein axonemal heavy chain,dynein cytoplasmic 1 heavy chain,dynein cytoplasmic 2 heavy chain
KOG3595Eukaryota (superkingdom)dynein axonemal heavy chain,dynein cytoplasmic 1 heavy chain,dynein cytoplasmic 2 heavy chain
HUT1ZMetazoa (kingdom)dynein axonemal heavy chain,dynein cytoplasmic 1 heavy chain,dynein cytoplasmic 2 heavy chain
940BAChordata (phylum)dynein axonemal heavy chain,dynein cytoplasmic 2 heavy chain,dynein cytoplasmic 1 heavy chain
5R853Sarcopterygii (superclass)dynein axonemal heavy chain
8YX2TMammalia (class)dynein axonemal heavy chain
4RC87Euarchontoglires (superorder)dynein axonemal heavy chain
4ZWGBPrimates (order)dynein axonemal heavy chain
98JEIHaplorrhini (suborder)dynein axonemal heavy chain
BV3ATSimiiformes (infraorder)dynein axonemal heavy chain
9EUVECatarrhini (parvorder)dynein axonemal heavy chain
7HU9FOpisthokonta (clade)dynein axonemal heavy chain,dynein cytoplasmic 1 heavy chain,dynein cytoplasmic 2 heavy chain
H4SE5Bilateria (clade)dynein axonemal heavy chain,dynein cytoplasmic 1 heavy chain,dynein cytoplasmic 2 heavy chain
9FIPCVertebrata (clade)dynein axonemal heavy chain,dynein cytoplasmic 2 heavy chain,dynein cytoplasmic 1 heavy chain
FX9FAHominoidea (superfamily)dynein axonemal heavy chain
5N24SHominidae (family)dynein axonemal heavy chain
5XRY5Homininae (subfamily)dynein axonemal heavy chain

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: