Domains within Homo sapiens protein ENSP00000347684.5

Alternative representations: 1 /

Protein length406 aa
Source databaseEnsembl
Identifiers ENSP00000347684.5, ENSP00000347684
Source gene ENSG00000136944
Alternative splicing ENSP00000436930.1, LMX1B_HUMAN, B7ZLH2_HUMAN, ENSP00000347684.5

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

ENSP00000347684.5 is shown as LMX1B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for LMX1B

Protein ENSP00000347684.5 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells

KEGG orthologous groups

KONameDescription
K09338HD-ZIPhomeobox-leucine zipper protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000347684 in eggNOG.

OGTaxonomic classDescription
LKOG0490All organisms (root)homeobox-leucine zipper protein,LIM homeobox transcription factor 1,LIM homeobox protein 2/9
KOG0490Eukaryota (superkingdom)homeobox-leucine zipper protein,LIM homeobox transcription factor 1,LIM homeobox protein 2/9
HVNCJMetazoa (kingdom)LIM homeobox transcription factor 1
93FV8Chordata (phylum)LIM homeobox transcription factor 1
5QU3VSarcopterygii (superclass)LIM homeobox transcription factor 1
8ZKHMMammalia (class)LIM homeobox transcription factor 1
4RRY7Euarchontoglires (superorder)LIM homeobox transcription factor 1
504KZPrimates (order)LIM homeobox transcription factor 1
98Q2UHaplorrhini (suborder)LIM homeobox transcription factor 1
BVCCQSimiiformes (infraorder)LIM homeobox transcription factor 1
9EXKCCatarrhini (parvorder)LIM homeobox transcription factor 1
H3C2XBilateria (clade)LIM homeobox transcription factor 1
9FW0YVertebrata (clade)LIM homeobox transcription factor 1
7HEEEOpisthokonta (clade)LIM homeobox transcription factor 1,insulin gene enhancer protein ISL-2
FXA6IHominoidea (superfamily)LIM homeobox transcription factor 1
5NEB2Hominidae (family)LIM homeobox transcription factor 1
5XUJWHomininae (subfamily)LIM homeobox transcription factor 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: