Domains within Homo sapiens protein ENSP00000356946.4

Alternative representations: 1 /

Protein length359 aa
Source databaseEnsembl
Identifiers ENSP00000356946.4, ENSP00000356946
Source gene ENSG00000203747
Alternative splicing ENSP00000356946.4, FCG3A_HUMAN, H0Y755_HUMAN, ENSP00000396567.1, ENSP00000491631.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000356946.4 is shown as FCGR3A in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for FCGR3A

Protein ENSP00000356946.4 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05140Leishmaniasis
map04650Natural killer cell mediated cytotoxicity

KEGG orthologous groups

KONameDescription
K06463FCGR3, CD16low affinity immunoglobulin gamma Fc receptor III

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000356946 in eggNOG.

OGTaxonomic classDescription
6XC4KAll organisms (root)low affinity immunoglobulin gamma Fc receptor III,Fc receptor-like protein,low affinity immunoglobulin gamma Fc receptor II-c
5JRWPEukaryota (superkingdom)low affinity immunoglobulin gamma Fc receptor III,Fc receptor-like protein,low affinity immunoglobulin gamma Fc receptor II-c
HU4BZMetazoa (kingdom)low affinity immunoglobulin gamma Fc receptor III,low affinity immunoglobulin gamma Fc receptor II-c
93Z8SChordata (phylum)low affinity immunoglobulin gamma Fc receptor III,low affinity immunoglobulin gamma Fc receptor II-c
5QAPMSarcopterygii (superclass)low affinity immunoglobulin gamma Fc receptor III,low affinity immunoglobulin gamma Fc receptor II-c
8YZX7Mammalia (class)low affinity immunoglobulin gamma Fc receptor III
4RKDHEuarchontoglires (superorder)low affinity immunoglobulin gamma Fc receptor III
4ZT73Primates (order)low affinity immunoglobulin gamma Fc receptor III
98AHGHaplorrhini (suborder)low affinity immunoglobulin gamma Fc receptor III
BVFS0Simiiformes (infraorder)low affinity immunoglobulin gamma Fc receptor III
9EUMZCatarrhini (parvorder)low affinity immunoglobulin gamma Fc receptor III
7JUYIOpisthokonta (clade)low affinity immunoglobulin gamma Fc receptor III,Fc receptor-like protein,low affinity immunoglobulin gamma Fc receptor II-c
9G13PVertebrata (clade)low affinity immunoglobulin gamma Fc receptor III,low affinity immunoglobulin gamma Fc receptor II-c
H5T4HBilateria (clade)low affinity immunoglobulin gamma Fc receptor III,low affinity immunoglobulin gamma Fc receptor II-c
FX12JHominoidea (superfamily)low affinity immunoglobulin gamma Fc receptor III
5N2XXHominidae (family)low affinity immunoglobulin gamma Fc receptor III
5XX2DHomininae (subfamily)low affinity immunoglobulin gamma Fc receptor III

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: