Domains within Homo sapiens protein ENSP00000388475.1

Alternative representations: 1 /

Protein length471 aa
Source databaseEnsembl
Identifiers ENSP00000388475.1, ENSP00000388475
Source gene ENSG00000063244
Alternative splicing ENSP00000388475.1, U2AF2_HUMAN, M0QYQ9_HUMAN, K7ELP8_HUMAN, K7ENG2_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000388475.1 is shown as U2AF2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for U2AF2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9669.ENSMPUP00000007078 in eggNOG.

OGTaxonomic classDescription
LKOG0120All organisms (root)splicing factor U2AF 65 kDa subunit,cofilin,poly(U)-binding-splicing factor PUF60
KOG0120Eukaryota (superkingdom)splicing factor U2AF 65 kDa subunit,cofilin,poly(U)-binding-splicing factor PUF60
HTU58Metazoa (kingdom)splicing factor U2AF 65 kDa subunit,epsin
94PHQChordata (phylum)splicing factor U2AF 65 kDa subunit,epsin
5RA58Sarcopterygii (superclass)splicing factor U2AF 65 kDa subunit,epsin
8ZCASMammalia (class)splicing factor U2AF 65 kDa subunit,epsin
BQP9CLaurasiatheria (superorder)splicing factor U2AF 65 kDa subunit
ARE60Carnivora (order)splicing factor U2AF 65 kDa subunit
HBFIWCaniformia (suborder)splicing factor U2AF 65 kDa subunit
9GAMFVertebrata (clade)splicing factor U2AF 65 kDa subunit,epsin
7H1IJOpisthokonta (clade)splicing factor U2AF 65 kDa subunit,epsin
H3C83Bilateria (clade)splicing factor U2AF 65 kDa subunit,epsin
E0I94Mustelidae (family)splicing factor U2AF 65 kDa subunit

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: