Domains within Homo sapiens protein ENSP00000394227.2

Alternative representations: 1 /

Protein length434 aa
Source databaseEnsembl
Identifiers ENSP00000394227.2, ENSP00000394227
Source gene ENSG00000198223
Alternative splicing CSF2R_HUMAN, ENSP00000410667.1, P15509-2, V9GYE9_HUMAN, P15509-6, F2Z3C9_HUMAN, P15509-5, P15509-3, ENSP00000440491.1, ENSP00000394227.2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000394227.2 is shown as CSF2RA in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CSF2RA

Protein ENSP00000394227.2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04630JAK-STAT signaling pathway

KEGG orthologous groups

KONameDescription
K05066CSF2RA, GMCSFR, CD116granulocyte-macrophage colony-stimulating factor receptor alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000394227 in eggNOG.

OGTaxonomic classDescription
78ERVAll organisms (root)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha,interleukin 5 receptor alpha
5FNSKEukaryota (superkingdom)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha,interleukin 5 receptor alpha
HW1JNMetazoa (kingdom)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha
93DF7Chordata (phylum)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha
5QC6QSarcopterygii (superclass)granulocyte-macrophage colony-stimulating factor receptor alpha
8Z1QSMammalia (class)granulocyte-macrophage colony-stimulating factor receptor alpha
4RFCEEuarchontoglires (superorder)granulocyte-macrophage colony-stimulating factor receptor alpha
4ZPDVPrimates (order)granulocyte-macrophage colony-stimulating factor receptor alpha
98IN2Haplorrhini (suborder)granulocyte-macrophage colony-stimulating factor receptor alpha
BVEBHSimiiformes (infraorder)granulocyte-macrophage colony-stimulating factor receptor alpha
9EHAMCatarrhini (parvorder)granulocyte-macrophage colony-stimulating factor receptor alpha
7IV88Opisthokonta (clade)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha
H67AHBilateria (clade)granulocyte-macrophage colony-stimulating factor receptor alpha,interleukin 3 receptor alpha
9FA61Vertebrata (clade)granulocyte-macrophage colony-stimulating factor receptor alpha
FWYY7Hominoidea (superfamily)granulocyte-macrophage colony-stimulating factor receptor alpha
5N9AGHominidae (family)granulocyte-macrophage colony-stimulating factor receptor alpha
5XVGSHomininae (subfamily)granulocyte-macrophage colony-stimulating factor receptor alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: