Domains within Homo sapiens protein ENSP00000397331.1

Alternative representations: 1 /

Protein length343 aa
Source databaseEnsembl
Identifiers ENSP00000397331.1, ENSP00000397331, ENSP00000383521.1, ENSP00000383521, ENSP00000409132.1, ENSP00000409132, ENSP00000387624.1, ENSP00000387624, ENSP00000366024.2, ENSP00000366024, ENSP00000392347.1, ENSP00000392347, ENSP00000383506.1, ENSP00000383506
Source gene ENSG00000235680
Alternative splicing ENSP00000397331.1, HLAG_HUMAN, Q31611_HUMAN, Q29897_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000397331.1 is shown as HLA-G in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for HLA-G

Protein ENSP00000397331.1 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05167Kaposi sarcoma-associated herpesvirus infection
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K06751MHC1MHC class I antigen

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000366024 in eggNOG.

OGTaxonomic classDescription
6WTPIAll organisms (root)MHC class I antigen,UL16 binding protein,retinoic acid early transcript 1
5J2S9Eukaryota (superkingdom)MHC class I antigen,UL16 binding protein,retinoic acid early transcript 1
HUWB1Metazoa (kingdom)MHC class I antigen
9449UChordata (phylum)MHC class I antigen
5QHUJSarcopterygii (superclass)MHC class I antigen
8Z4KUMammalia (class)MHC class I antigen
4R8YVEuarchontoglires (superorder)MHC class I antigen
H719BBilateria (clade)MHC class I antigen
9G6JWVertebrata (clade)MHC class I antigen
7I7RMOpisthokonta (clade)MHC class I antigen

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: