Domains within Homo sapiens protein ENSP00000402953.2

Alternative representations: 1 /

Protein length516 aa
Source databaseEnsembl
Identifiers ENSP00000402953.2, ENSP00000402953, ENSP00000487945.1, ENSP00000487945
Source gene ENSG00000274081
Alternative splicing ENSP00000488595.1, ENSP00000488435.1, ENSP00000487614.1, ENSP00000402953.2, ENSP00000322016.7, ENSP00000488903.1, H0YCP8_HUMAN, ENSP00000487637.1, ENSP00000488027.1, E9PN18_HUMAN, ENSP00000437309.1, E9PL19_HUMAN, PUF60_HUMAN, ENSP00000395417.2, ENSP00000322036.7

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000402953.2 is shown as PUF60 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PUF60

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9568.ENSMLEP00000031643 in eggNOG.

OGTaxonomic classDescription
LKOG0124All organisms (root)poly(U)-binding-splicing factor PUF60
KOG0124Eukaryota (superkingdom)poly(U)-binding-splicing factor PUF60
HU0DAMetazoa (kingdom)poly(U)-binding-splicing factor PUF60
93YM7Chordata (phylum)poly(U)-binding-splicing factor PUF60
5QK6SSarcopterygii (superclass)poly(U)-binding-splicing factor PUF60
8ZNPVMammalia (class)poly(U)-binding-splicing factor PUF60
4R58JEuarchontoglires (superorder)poly(U)-binding-splicing factor PUF60
4ZW8RPrimates (order)poly(U)-binding-splicing factor PUF60
98994Haplorrhini (suborder)poly(U)-binding-splicing factor PUF60
BV0EMSimiiformes (infraorder)poly(U)-binding-splicing factor PUF60
9EHXFCatarrhini (parvorder)poly(U)-binding-splicing factor PUF60
H745RBilateria (clade)poly(U)-binding-splicing factor PUF60
7KTF2Opisthokonta (clade)poly(U)-binding-splicing factor PUF60
9G8TYVertebrata (clade)poly(U)-binding-splicing factor PUF60
6I5TMCercopithecidae (family)poly(U)-binding-splicing factor PUF60
BRA7QCercopithecinae (subfamily)poly(U)-binding-splicing factor PUF60

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: