Domains within Homo sapiens protein ENSP00000409007.1

Alternative representations: 1 /

Protein length228 aa
Source databaseEnsembl
Identifiers ENSP00000409007.1, ENSP00000409007
Source gene ENSG00000168621
Alternative splicing GDNF_HUMAN, ENSP00000371248.4, ENSP00000409007.1, ENSP00000425928.1, ENSP00000424592.1, ENSP00000478722.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eumetazoa

Predicted functional partners

ENSP00000409007.1 is shown as GDNF in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GDNF

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9597.ENSPPAP00000002916 in eggNOG.

OGTaxonomic classDescription
75N08All organisms (root)glial cell derived neurotrophic factor
5GQ8NEukaryota (superkingdom)glial cell derived neurotrophic factor
HTGZNMetazoa (kingdom)glial cell derived neurotrophic factor
941BXChordata (phylum)glial cell derived neurotrophic factor
5QNT9Sarcopterygii (superclass)glial cell derived neurotrophic factor
8YU1FMammalia (class)glial cell derived neurotrophic factor
4RQT6Euarchontoglires (superorder)glial cell derived neurotrophic factor
4ZSZ7Primates (order)glial cell derived neurotrophic factor
98CWAHaplorrhini (suborder)glial cell derived neurotrophic factor
BV7JTSimiiformes (infraorder)glial cell derived neurotrophic factor
9EWCCCatarrhini (parvorder)glial cell derived neurotrophic factor
7KH5ROpisthokonta (clade)glial cell derived neurotrophic factor
H5ACWBilateria (clade)glial cell derived neurotrophic factor
9FFGQVertebrata (clade)glial cell derived neurotrophic factor
FX8ERHominoidea (superfamily)glial cell derived neurotrophic factor
5N4HJHominidae (family)glial cell derived neurotrophic factor
5XTPYHomininae (subfamily)glial cell derived neurotrophic factor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: