Domains within Homo sapiens protein ENSP00000420746.1

Alternative representations: 1 /

Protein length181 aa
Source databaseEnsembl
Identifiers ENSP00000420746.1, ENSP00000420746
Source gene ENSG00000163590
Alternative splicing ENSP00000420354.1, PPM1L_HUMAN, ENSP00000420746.1, ENSP00000295839.9

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000420746.1 is shown as PPM1L in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PPM1L

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 1868482.ENSTSYP00000017548 in eggNOG.

OGTaxonomic classDescription
LCOG0631All organisms (root)PPM family protein phosphatase [EC:3.1.3.16],protein phosphatase 1L [EC:3.1.3.16],pyruvate dehydrogenase phosphatase [EC:3.1.3.43]
KOG0698Eukaryota (superkingdom)protein phosphatase 1L [EC:3.1.3.16],protein phosphatase PTC2/3 [EC:3.1.3.16],protein phosphatase 2C [EC:3.1.3.16]
HTEDNMetazoa (kingdom)protein phosphatase 1L [EC:3.1.3.16]
948AMChordata (phylum)protein phosphatase 1L [EC:3.1.3.16]
5QJFXSarcopterygii (superclass)protein phosphatase 1L [EC:3.1.3.16]
8ZKCUMammalia (class)protein phosphatase 1L [EC:3.1.3.16]
4RFN7Euarchontoglires (superorder)protein phosphatase 1L [EC:3.1.3.16]
4ZMNHPrimates (order)protein phosphatase 1L [EC:3.1.3.16]
98DT0Haplorrhini (suborder)protein phosphatase 1L [EC:3.1.3.16]
7HCPMOpisthokonta (clade)protein phosphatase 1L [EC:3.1.3.16],protein phosphatase 1K [EC:3.1.3.16],protein phosphatase PTC6 [EC:3.1.3.16 3.1.3.43]
H4S0ABilateria (clade)protein phosphatase 1L [EC:3.1.3.16]
9FGKSVertebrata (clade)protein phosphatase 1L [EC:3.1.3.16]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: