Domains within Homo sapiens protein ENSP00000430604.1

Alternative representations: 1 /

Protein length288 aa
Source databaseEnsembl
Identifiers ENSP00000430604.1, ENSP00000430604
Source gene ENSG00000180228
Alternative splicing PRKRA_HUMAN, ENSP00000408029.1, ENSP00000430604.1, ENSP00000393883.2, F8WEG8_HUMAN, ENSP00000408668.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

ENSP00000430604.1 is shown as PRKRA in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PRKRA

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9568.ENSMLEP00000004333 in eggNOG.

OGTaxonomic classDescription
LKOG3732All organisms (root)double-stranded RNA-binding protein Staufen,RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
KOG3732Eukaryota (superkingdom)double-stranded RNA-binding protein Staufen,RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
HTYT3Metazoa (kingdom)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
93NNNChordata (phylum)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
5QJF5Sarcopterygii (superclass)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
8ZIB7Mammalia (class)interferon-inducible double-stranded RNA-dependent protein kinase activator A
4R5R9Euarchontoglires (superorder)interferon-inducible double-stranded RNA-dependent protein kinase activator A
4ZYK8Primates (order)interferon-inducible double-stranded RNA-dependent protein kinase activator A
98RNEHaplorrhini (suborder)interferon-inducible double-stranded RNA-dependent protein kinase activator A
BVEN7Simiiformes (infraorder)interferon-inducible double-stranded RNA-dependent protein kinase activator A
9EMI8Catarrhini (parvorder)interferon-inducible double-stranded RNA-dependent protein kinase activator A
7GCRYOpisthokonta (clade)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
9G4H4Vertebrata (clade)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
H6NT3Bilateria (clade)RISC-loading complex subunit TARBP2,interferon-inducible double-stranded RNA-dependent protein kinase activator A
6I4EVCercopithecidae (family)interferon-inducible double-stranded RNA-dependent protein kinase activator A
BR4C7Cercopithecinae (subfamily)interferon-inducible double-stranded RNA-dependent protein kinase activator A

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: