Domains within Homo sapiens protein ENSP00000447173.1

Alternative representations: 1 /

Protein length477 aa
Source databaseEnsembl
Identifiers ENSP00000447173.1, ENSP00000447173
Source gene ENSG00000111424
Alternative splicing VDR_HUMAN, ENSP00000447173.1, F8VXQ9_HUMAN, ENSP00000448659.1, ENSP00000449561.1, ENSP00000450105.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

ENSP00000447173.1 is shown as VDR in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for VDR

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9598.ENSPTRP00000084220 in eggNOG.

OGTaxonomic classDescription
LKOG3575All organisms (root)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
KOG3575Eukaryota (superkingdom)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
HV6FZMetazoa (kingdom)vitamin D3 receptor,nuclear receptor subfamily 1 group I
94VCPChordata (phylum)vitamin D3 receptor
5QWRUSarcopterygii (superclass)vitamin D3 receptor
8ZH54Mammalia (class)vitamin D3 receptor
4RAPEEuarchontoglires (superorder)vitamin D3 receptor
4ZJA3Primates (order)vitamin D3 receptor
98DJFHaplorrhini (suborder)vitamin D3 receptor
BV6VASimiiformes (infraorder)vitamin D3 receptor
9EYN2Catarrhini (parvorder)vitamin D3 receptor
9FW8ZVertebrata (clade)vitamin D3 receptor
H6UPDBilateria (clade)vitamin D3 receptor,nuclear receptor subfamily 1 group I
7JBXVOpisthokonta (clade)vitamin D3 receptor,farnesoid X receptor,liver X receptor alpha
FX386Hominoidea (superfamily)vitamin D3 receptor
5N2JFHominidae (family)vitamin D3 receptor
5XVTTHomininae (subfamily)vitamin D3 receptor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: