Domains within Homo sapiens protein ENSP00000483403.1

Alternative representations: 1 /

Protein length645 aa
Source databaseEnsembl
Identifiers ENSP00000483403.1, ENSP00000483403
Source gene ENSG00000112964
Alternative splicing GHR_HUMAN, E9PCN7_HUMAN, E7ES05_HUMAN, P10912-4, A0A087X162_HUMAN, ENSP00000483403.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ENSP00000483403.1 is shown as GHR in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GHR

Protein ENSP00000483403.1 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04630JAK-STAT signaling pathway

KEGG orthologous groups

KONameDescription
K05080GHRgrowth hormone receptor
K08136SPOCKtestican

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000483403 in eggNOG.

OGTaxonomic classDescription
LKOG3555All organisms (root)testican,growth hormone receptor,nidogen (entactin)
5EC0DEukaryota (superkingdom)growth hormone receptor
HW5IAMetazoa (kingdom)growth hormone receptor
93ZPWChordata (phylum)growth hormone receptor
5R0PYSarcopterygii (superclass)growth hormone receptor
8ZKWYMammalia (class)growth hormone receptor
4RKJCEuarchontoglires (superorder)growth hormone receptor
4ZPE4Primates (order)growth hormone receptor
98NB9Haplorrhini (suborder)growth hormone receptor
BV901Simiiformes (infraorder)growth hormone receptor
9EPDFCatarrhini (parvorder)growth hormone receptor
9GN9PVertebrata (clade)growth hormone receptor
H3QWSBilateria (clade)growth hormone receptor
7HM3JOpisthokonta (clade)growth hormone receptor
FXDJGHominoidea (superfamily)growth hormone receptor
5N3VCHominidae (family)growth hormone receptor
5XTK9Homininae (subfamily)growth hormone receptor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: