Domains within Homo sapiens protein F5H5D3_HUMAN (F5H5D3)

Tubulin alpha chain

Alternative representations: 1 /

Protein length519 aa
Source databaseUniProt
Identifiers F5H5D3_HUMAN, F5H5D3, ENSP00000443475.1, ENSP00000443475, X1R3P6_9ZZZZ, X1R3P6
Source gene ENSG00000167553
Alternative splicing F5H5D3_HUMAN, F8VRK1_HUMAN, H0YHV2_HUMAN, TBA1C_HUMAN, F8VS66_HUMAN, A0A1W2PQM2_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

F5H5D3_HUMAN is shown as TUBA1C in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TUBA1C

Protein F5H5D3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K07374TUBAtubulin alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000443475 in eggNOG.

OGTaxonomic classDescription
LKOG1376All organisms (root)tubulin alpha,tubulin beta,small subunit ribosomal protein S34
KOG1376Eukaryota (superkingdom)tubulin alpha,tubulin beta,small subunit ribosomal protein S34
HUI0YMetazoa (kingdom)tubulin alpha,sialidase-1 [EC:3.2.1.18],ganglioside-induced differentiation-associated protein 1
94D5GChordata (phylum)tubulin alpha,sialidase-1 [EC:3.2.1.18],ganglioside-induced differentiation-associated protein 1
5RAVASarcopterygii (superclass)tubulin alpha,DnaJ homolog subfamily B member 2,peroxin-26
8Z3Y7Mammalia (class)tubulin alpha
4REGEEuarchontoglires (superorder)tubulin alpha
4ZRXXPrimates (order)tubulin alpha
98FJPHaplorrhini (suborder)tubulin alpha
BV04RSimiiformes (infraorder)tubulin alpha
9EPQVCatarrhini (parvorder)tubulin alpha
7N6RPOpisthokonta (clade)tubulin alpha,sialidase-1 [EC:3.2.1.18],ganglioside-induced differentiation-associated protein 1
H3C98Bilateria (clade)tubulin alpha,sialidase-1 [EC:3.2.1.18],ganglioside-induced differentiation-associated protein 1
9FGE9Vertebrata (clade)tubulin alpha,ganglioside-induced differentiation-associated protein 1,DnaJ homolog subfamily B member 2
FX71XHominoidea (superfamily)tubulin alpha
5N2N6Hominidae (family)tubulin alpha
5XY24Homininae (subfamily)tubulin alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: