Domains within Homo sapiens protein F5H8B4_HUMAN (F5H8B4)
Histone demethylase UTY
Alternative representations: 1 /
| Protein length | 1444 aa |
|---|---|
| Source database | UniProt |
| Identifiers | F5H8B4_HUMAN, F5H8B4, ENSP00000442047.2, ENSP00000442047 |
| Source gene | ENSG00000183878 |
| Alternative splicing | UTY_HUMAN, O14607-5, O14607-3, O14607-2, A6NCS7_HUMAN, F5H3N7_HUMAN, F5GWV3_HUMAN, O14607-4, A0A096LPD8_HUMAN, F5H8B4_HUMAN, A0A087X0Y2_HUMAN, A0A087X248_HUMAN, A0A087X2I9_HUMAN |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Amniota
Predicted functional partners
F5H8B4_HUMAN is shown as 
UTY in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein F5H8B4_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04550 | Signaling pathways regulating pluripotency of stem cells | |
| map05202 | Transcriptional misregulation in cancer | |
| map05020 | Prion disease |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K11446 | KDM5, JARID1 | [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67] | |
| K11447 | UTX, KDM6A | lysine-specific demethylase 6A [EC:1.14.11.68] | |
| K23742 | UTY, KDM6C | lysine-specific demethylase 6C [EC:1.14.11.68] | |
| K02112 | ATPF1B, atpD | F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] | iPath3 |
| K23424 | TMTC | protein O-mannosyl-transferase [EC:2.4.1.-] |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000442047 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0055 | All organisms (root) | F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1],[histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67],F-type H+-transporting ATPase subunit beta [EC:7.1.2.2] |
| LCOG0457 | All organisms (root) | protein O-mannosyl-transferase [EC:2.4.1.-],kinesin light chain,Ca-activated chloride channel homolog |
| KOG1246 | Eukaryota (superkingdom) | [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67],protein Jumonji,lysine-specific demethylase 6A [EC:1.14.11.68] |
| KOG1124 | Eukaryota (superkingdom) | protein O-mannosyl-transferase [EC:2.4.1.-],5'-nucleotidase [EC:3.1.3.5],Bardet-Biedl syndrome 4 protein |
| HUAUQ | Metazoa (kingdom) | lysine-specific demethylase 6A [EC:1.14.11.68],lysine-specific demethylase 6B [EC:1.14.11.68],lysine-specific demethylase 6C [EC:1.14.11.68] |
| 93NVY | Chordata (phylum) | lysine-specific demethylase 6C [EC:1.14.11.68],lysine-specific demethylase 6A [EC:1.14.11.68] |
| 5QY0Z | Sarcopterygii (superclass) | lysine-specific demethylase 6C [EC:1.14.11.68],lysine-specific demethylase 6A [EC:1.14.11.68] |
| 8ZCD4 | Mammalia (class) | lysine-specific demethylase 6C [EC:1.14.11.68],lysine-specific demethylase 6A [EC:1.14.11.68] |
| 4RFBJ | Euarchontoglires (superorder) | lysine-specific demethylase 6C [EC:1.14.11.68],lysine-specific demethylase 6A [EC:1.14.11.68] |
| 50516 | Primates (order) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| 98RED | Haplorrhini (suborder) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| BVCJJ | Simiiformes (infraorder) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| 9F07H | Catarrhini (parvorder) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| 7ISM0 | Opisthokonta (clade) | lysine-specific demethylase 6A [EC:1.14.11.68],lysine-specific demethylase 6B [EC:1.14.11.68],lysine-specific demethylase 6C [EC:1.14.11.68] |
| 9G9CA | Vertebrata (clade) | lysine-specific demethylase 6C [EC:1.14.11.68],lysine-specific demethylase 6A [EC:1.14.11.68] |
| H6NBC | Bilateria (clade) | lysine-specific demethylase 6A [EC:1.14.11.68],lysine-specific demethylase 6C [EC:1.14.11.68],atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48] |
| FWZ70 | Hominoidea (superfamily) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| 5N1VH | Hominidae (family) | lysine-specific demethylase 6C [EC:1.14.11.68] |
| 5Y47U | Homininae (subfamily) | lysine-specific demethylase 6C [EC:1.14.11.68] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.