Domains within Caenorhabditis elegans protein FOXO_CAEEL (O16850)

Forkhead box protein O

Alternative representations: 1 /

Protein length541 aa
Source databaseUniProt
Identifiers FOXO_CAEEL, O16850, R13H8.1H, F3NWW7, F3NWX0, G4RQR7, G4S686, G4SKG3, G4SKH0, O16849, O18676, Q86S42, O16850-5, O16850-1, O16850-6, A0A0K3AR95_CAEEL, A0A0K3AR95
Source gene WBGene00000912
Alternative splicing O16850-2, O16850-4, O16850-3, R13H8.1d, R13H8.1e, R13H8.1f, O16850-7, FOXO_CAEEL, A0A0K3AWG6_CAEEL, R13H8.1k, R13H8.1l, R13H8.1m

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

FOXO_CAEEL is shown as daf-16 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for daf-16

Protein FOXO_CAEEL is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04211Longevity regulating pathway
map04068FoxO signaling pathway
map05131Shigellosis

KEGG orthologous groups

KONameDescription
K09408FOXO3forkhead box protein O3
K09407FOXNforkhead box protein N

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 6239.R13H8.1h.1 in eggNOG.

OGTaxonomic classDescription
LKOG2294All organisms (root)forkhead box protein N,forkhead box protein D,forkhead box protein I
KOG2294Eukaryota (superkingdom)forkhead box protein N,forkhead box protein D,forkhead box protein I
HVYIBMetazoa (kingdom)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
8BMIWNematoda (phylum)forkhead box protein O3
HDGZPChromadorea (class)forkhead box protein O3
6DPSZRhabditida (order)forkhead box protein O3
8PTCXRhabditina (suborder)forkhead box protein O3
7H334Opisthokonta (clade)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
H720WBilateria (clade)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
AYPNJRhabditidae (family)forkhead box protein O3
BT5X8Caenorhabditis (genus)forkhead box protein O3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: