Domains within Mus musculus protein H7BX01_MOUSE (H7BX01)

Dynamin-like 120 kDa protein, mitochondrial

Alternative representations: 1 /

Protein length978 aa
Source databaseUniProt
Identifiers H7BX01_MOUSE, H7BX01, ENSMUSP00000036993.6, ENSMUSP00000036993
Source gene ENSMUSG00000038084
Alternative splicing OPA1_MOUSE, E0CXD1_MOUSE, ENSMUSP00000123880.1, H7BX01_MOUSE, F6U775_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

H7BX01_MOUSE is shown as Opa1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Opa1

Protein H7BX01_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05017Spinocerebellar ataxia
map04621NOD-like receptor signaling pathway

KEGG orthologous groups

KONameDescription
K17079OPA1optic atrophy protein 1 [EC:3.6.5.5]
K17065DNM1Ldynamin 1-like protein [EC:3.6.5.5]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000036993 in eggNOG.

OGTaxonomic classDescription
LCOG0699All organisms (root)dynamin 1-like protein [EC:3.6.5.5],dynamin 1/3 [EC:3.6.5.5],mitofusin 2 [EC:3.6.5.-]
KOG0447Eukaryota (superkingdom)optic atrophy protein 1 [EC:3.6.5.5]
HTFIKMetazoa (kingdom)optic atrophy protein 1 [EC:3.6.5.5]
94QKRChordata (phylum)optic atrophy protein 1 [EC:3.6.5.5]
5R4IYSarcopterygii (superclass)optic atrophy protein 1 [EC:3.6.5.5]
8Z75DMammalia (class)optic atrophy protein 1 [EC:3.6.5.5]
4RM9AEuarchontoglires (superorder)optic atrophy protein 1 [EC:3.6.5.5]
AHXFSRodentia (order)optic atrophy protein 1 [EC:3.6.5.5]
8DIDKMyomorpha (suborder)optic atrophy protein 1 [EC:3.6.5.5]
7IF6EOpisthokonta (clade)optic atrophy protein 1 [EC:3.6.5.5]
H3T6YBilateria (clade)optic atrophy protein 1 [EC:3.6.5.5]
9GPMNVertebrata (clade)optic atrophy protein 1 [EC:3.6.5.5]
CQGT6Muridae (family)optic atrophy protein 1 [EC:3.6.5.5]
AE2WMMurinae (subfamily)optic atrophy protein 1 [EC:3.6.5.5]
5PIC5Mus (genus)optic atrophy protein 1 [EC:3.6.5.5]
HEFAVMus (subgenus)optic atrophy protein 1 [EC:3.6.5.5]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: