Domains within Mus musculus protein HXA10_MOUSE (P31310)

Homeobox protein Hox-A10

Alternative representations: 1 /

Protein length416 aa
Source databaseUniProt
Identifiers HXA10_MOUSE, P31310, ENSMUSP00000120276.1, ENSMUSP00000120276, Q80Y22
Source gene ENSMUSG00000000938
Alternative splicing HXA10_MOUSE, P31310-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

HXA10_MOUSE is shown as Hoxa10 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Hoxa10

Protein HXA10_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K17443HOXA10homrobox protein Hox-A10
K09298HOX_13homeobox protein HoxA/B/C/D13

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 14 PTMs annotated in this protein:

PTMCount
Phosphorylation9
Acetylation3
Ubiquitination2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Hoxa10.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000120276 in eggNOG.

OGTaxonomic classDescription
LKOG0487All organisms (root)homeobox protein HoxA/B/C/D13,homeobox protein HoxB/C/D9,homeobox protein HoxC/D12
KOG0487Eukaryota (superkingdom)homeobox protein HoxA/B/C/D13,homeobox protein HoxB/C/D9,homeobox protein HoxC/D12
HUPF6Metazoa (kingdom)homrobox protein Hox-A10,homeobox protein abdominal-B and related proteins,homeobox protein Hox-A11
93PP1Chordata (phylum)homrobox protein Hox-A10,homeobox protein Hox-A11
5QIDTSarcopterygii (superclass)homrobox protein Hox-A10
8YZNIMammalia (class)homrobox protein Hox-A10
4R48DEuarchontoglires (superorder)homrobox protein Hox-A10
AIFW3Rodentia (order)homrobox protein Hox-A10
8D6GYMyomorpha (suborder)homrobox protein Hox-A10
9GJSUVertebrata (clade)homrobox protein Hox-A10,homeobox protein Hox-A11
7H1IFOpisthokonta (clade)homrobox protein Hox-A10,homeobox protein abdominal-B and related proteins,homeobox protein Hox-A11
H6A11Bilateria (clade)homrobox protein Hox-A10,homeobox protein abdominal-B and related proteins,homeobox protein Hox-A11
CQ1V6Muridae (family)homrobox protein Hox-A10
AEACRMurinae (subfamily)homrobox protein Hox-A10
5PTQIMus (genus)homrobox protein Hox-A10
HEFXWMus (subgenus)homrobox protein Hox-A10

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: