Domains within Homo sapiens protein J3KTH2_HUMAN (J3KTH2)

HCG38478, isoform CRA_a

Alternative representations: 1 /

Protein length867 aa
Source databaseUniProt
Identifiers J3KTH2_HUMAN, J3KTH2, ENSP00000462980.1, ENSP00000462980, B6IDA8_9ZZZZ, B6IDA8, A4PBF8_HUMAN, A4PBF8
Source gene ENSG00000141384
Alternative splicing TAF4B_HUMAN, J3KTH2_HUMAN, Q92750-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

J3KTH2_HUMAN is shown as TAF4B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TAF4B

Protein J3KTH2_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K03129TAF4transcription initiation factor TFIID subunit 4

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000462980 in eggNOG.

OGTaxonomic classDescription
LKOG2341All organisms (root)transcription initiation factor TFIID subunit 4
KOG2341Eukaryota (superkingdom)transcription initiation factor TFIID subunit 4
HVWQHMetazoa (kingdom)transcription initiation factor TFIID subunit 4
94H5EChordata (phylum)transcription initiation factor TFIID subunit 4
5RDZKSarcopterygii (superclass)transcription initiation factor TFIID subunit 4
8YVSVMammalia (class)transcription initiation factor TFIID subunit 4
4R6N7Euarchontoglires (superorder)transcription initiation factor TFIID subunit 4
50103Primates (order)transcription initiation factor TFIID subunit 4
98NT2Haplorrhini (suborder)transcription initiation factor TFIID subunit 4
BVJMWSimiiformes (infraorder)transcription initiation factor TFIID subunit 4
9EY2ZCatarrhini (parvorder)transcription initiation factor TFIID subunit 4
H3XSYBilateria (clade)transcription initiation factor TFIID subunit 4
7KMPGOpisthokonta (clade)transcription initiation factor TFIID subunit 4
9GBEAVertebrata (clade)transcription initiation factor TFIID subunit 4
FXC2SHominoidea (superfamily)transcription initiation factor TFIID subunit 4
5NB4MHominidae (family)transcription initiation factor TFIID subunit 4
5Y4K6Homininae (subfamily)transcription initiation factor TFIID subunit 4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: