Domains within Mus musculus protein KI21A_MOUSE (Q9QXL2)

Kinesin-like protein KIF21A

Alternative representations: 1 /

Protein length1672 aa
Source databaseUniProt
Identifiers KI21A_MOUSE, Q9QXL2, ENSMUSP00000085985.5, ENSMUSP00000085985, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1
Source gene ENSMUSG00000022629
Alternative splicing KI21A_MOUSE, Q9QXL2-3, F8WGN6_MOUSE, ENSMUSP00000154845.1, ENSMUSP00000155710.1, Q9QXL2-2, E9Q0J5_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

KI21A_MOUSE is shown as Kif21a in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Kif21a

Protein KI21A_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K10395KIF4kinesin family member 4

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 31 PTMs annotated in this protein:

PTMCount
Phosphorylation28
Acetylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Kif21a.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000085985 in eggNOG.

OGTaxonomic classDescription
LKOG0244All organisms (root)kinesin family member 4,kinesin family member 21,kinesin family member 27
KOG0244Eukaryota (superkingdom)kinesin family member 4,kinesin family member 21,kinesin family member 27
HU1ACMetazoa (kingdom)kinesin family member 21,kinesin family member 4,kinesin family member 5
94R17Chordata (phylum)kinesin family member 21,kinesin family member 4
5R2KHSarcopterygii (superclass)kinesin family member 21
8ZCXMMammalia (class)kinesin family member 21
4R3Z8Euarchontoglires (superorder)kinesin family member 21
AHYYDRodentia (order)kinesin family member 21
8DHDYMyomorpha (suborder)kinesin family member 21
H6DB5Bilateria (clade)kinesin family member 21,kinesin family member 4,kinesin family member 5
7MHSUOpisthokonta (clade)kinesin family member 21,kinesin family member 4,kinesin family member 5
9GF96Vertebrata (clade)kinesin family member 21
CQC4NMuridae (family)kinesin family member 21
ADXT4Murinae (subfamily)kinesin family member 21
5PG22Mus (genus)kinesin family member 21
HE4EIMus (subgenus)kinesin family member 21

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: