Domains within Homo sapiens protein LCK_HUMAN (P06239)
Tyrosine-protein kinase Lck
Alternative representations: 1 /
| Protein length | 509 aa |
|---|---|
| Source database | UniProt |
| Identifiers | LCK_HUMAN, P06239, ENSP00000337825.5, ENSP00000337825, ENSP00000477713.1, ENSP00000477713, D3DPP8, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q7RTZ3, Q96DW4, Q9NYT8, A0A2J8IYW0_PANTR, A0A2J8IYW0, A0A0S2Z3Y8_HUMAN, A0A0S2Z3Y8, A0A2J8IYW7_PANTR, A0A2J8IYW7, G3QJD4_GORGO, G3QJD4 |
| Source gene | ENSG00000182866 |
| Alternative splicing | LCK_HUMAN, E9PKQ8_HUMAN, ENSP00000435605.1, ENSP00000434525.1, ENSP00000362663.3, E9PI33_HUMAN, E9PAP0_HUMAN, ENSP00000328213.4, Q573B4_HUMAN |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Metazoa
Predicted functional partners
LCK_HUMAN is shown as 
LCK in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein LCK_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map05120 | Epithelial cell signaling in Helicobacter pylori infection | |
| map04360 | Axon guidance | |
| map04658 | Th1 and Th2 cell differentiation | |
| map04062 | Chemokine signaling pathway |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K05728 | CSK | c-src tyrosine kinase [EC:2.7.10.2] | |
| K05704 | SRC | tyrosine-protein kinase Src [EC:2.7.10.2] | |
| K08852 | ERN1 | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] | |
| K05705 | YES1 | tyrosine-protein kinase Yes [EC:2.7.10.2] | |
| K08893 | HCK | hemopoietic cell kinase [EC:2.7.10.2] | |
| K05856 | LCK | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] | |
| K08892 | FRK, PTK5 | fyn-related kinase [EC:2.7.10.2] |
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 37 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 28 |
 | Ubiquitination | 5 |
 | Palmitoylation | 2 |
 | Myristoylation | 1 |
 | Acetylation | 1 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSG00000182866.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000477713 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0478 | All organisms (root) | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1] |
| KOG0197 | Eukaryota (superkingdom) | fyn-related kinase [EC:2.7.10.2],c-src tyrosine kinase [EC:2.7.10.2],Janus kinase 2 [EC:2.7.10.2] |
| HSSCZ | Metazoa (kingdom) | fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 93EQ1 | Chordata (phylum) | tyrosine-protein kinase Yes [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2],tyrosine-protein kinase Lyn [EC:2.7.10.2] |
| 5QIHJ | Sarcopterygii (superclass) | hemopoietic cell kinase [EC:2.7.10.2],lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 8Z8Z5 | Mammalia (class) | hemopoietic cell kinase [EC:2.7.10.2],lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 4RBH8 | Euarchontoglires (superorder) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2],hemopoietic cell kinase [EC:2.7.10.2] |
| 4ZPTK | Primates (order) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 98BN5 | Haplorrhini (suborder) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| BV0FF | Simiiformes (infraorder) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 9EHWZ | Catarrhini (parvorder) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 9FM4B | Vertebrata (clade) | tyrosine-protein kinase Yes [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2],tyrosine-protein kinase Lyn [EC:2.7.10.2] |
| H5CVP | Bilateria (clade) | tyrosine-protein kinase Src [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 7IBRR | Opisthokonta (clade) | c-src tyrosine kinase [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2] |
| FXERX | Hominoidea (superfamily) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 5N132 | Hominidae (family) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
| 5XVAV | Homininae (subfamily) | lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.