Domains within Drosophila melanogaster protein M9PF16_DROME (M9PF16)

Spectrin beta chain

Alternative representations: 1 /

Protein length2308 aa
Source databaseUniProt
Identifiers M9PF16_DROME, M9PF16, FBPP0306507, B4IF35_DROSE, B4IF35
Source gene FBgn0250788
Alternative splicing M9PHG4_DROME, M9PF16_DROME, SPTCB_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

M9PF16_DROME is shown as beta-Spec in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for beta-Spec

Protein M9PF16_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05022Pathways of neurodegeneration - multiple diseases

KEGG orthologous groups

KONameDescription
K06115SPTBN1_4_5spectrin beta, non-erythrocytic 1/4/5

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0306507 in eggNOG.

OGTaxonomic classDescription
EJ0WZEndopterygota (cohort)spectrin beta
FV12Cmelanogaster group (species group)spectrin beta
LKOG0517All organisms (root)spectrin beta,spectrin beta, non-erythrocytic 2,spectrin alpha
FDVYGmelanogaster subgroup (species subgroup)spectrin beta
KOG0517Eukaryota (superkingdom)spectrin beta,spectrin beta, non-erythrocytic 2,spectrin alpha
HT9WNMetazoa (kingdom)spectrin beta,spectrin beta, non-erythrocytic 2,spectrin alpha
HHTYXArthropoda (phylum)spectrin beta
85RU7Hexapoda (subphylum)spectrin beta
AGWHDNeoptera (infraclass)spectrin beta
ANGKWDiptera (order)spectrin beta
H5FP8Bilateria (clade)spectrin beta,spectrin beta, non-erythrocytic 2,spectrin alpha
7MPMCOpisthokonta (clade)spectrin beta,spectrin beta, non-erythrocytic 2,spectrin alpha
EGTICDrosophila (genus)spectrin beta
50IBRSophophora (subgenus)spectrin beta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: