Domains within Drosophila melanogaster protein M9PFS1_DROME (M9PFS1)

Abl tyrosine kinase, isoform F

Alternative representations: 1 /

Protein length1723 aa
Source databaseUniProt
Identifiers M9PFS1_DROME, M9PFS1, FBPP0303166
Source gene FBgn0000017
Alternative splicing M9PFS1_DROME, M9PFI5_DROME, M9PCU1_DROME, ABL_DROME, M9PFX0_DROME, M9PCT8_DROME, FBpp0111702, M9PFI8_DROME, M9PI83_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

M9PFS1_DROME is shown as Abl in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Abl

Protein M9PFS1_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05416Viral myocarditis
map04014Ras signaling pathway
map04360Axon guidance
map04012ErbB signaling pathway

KEGG orthologous groups

KONameDescription
K06619ABL1abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K08852ERN1serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0303166 in eggNOG.

OGTaxonomic classDescription
EIVW7Endopterygota (cohort)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
FV4FHmelanogaster group (species group)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
FE3PBmelanogaster subgroup (species subgroup)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
LCOG0478All organisms (root)serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1]
KOG4278Eukaryota (superkingdom)abelson tyrosine-protein kinase 1 [EC:2.7.10.2],abelson tyrosine-protein kinase 2 [EC:2.7.10.2],multiple epidermal growth factor-like domains protein 10/11
HV1B6Metazoa (kingdom)abelson tyrosine-protein kinase 1 [EC:2.7.10.2],abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
HHRFIArthropoda (phylum)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
85YWFHexapoda (subphylum)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
AH2UTNeoptera (infraclass)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
ANYIBDiptera (order)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
H46IGBilateria (clade)abelson tyrosine-protein kinase 1 [EC:2.7.10.2],abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
7ITZTOpisthokonta (clade)abelson tyrosine-protein kinase 1 [EC:2.7.10.2],abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
EH79VDrosophila (genus)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
50GDCSophophora (subgenus)abelson tyrosine-protein kinase 1 [EC:2.7.10.2]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: