Domains within Homo sapiens protein NANP8_HUMAN (Q6NSW7)

Homeobox protein NANOGP8

Alternative representations: 1 /

Protein length305 aa
Source databaseUniProt
Identifiers NANP8_HUMAN, Q6NSW7, ENSP00000487073.1, ENSP00000487073, J7H3Y9, J7H3Z5, J7H408, J7H412, J7H416, J7H738, J7H745, J7H749, J7H9S6, J7H9T4, J7HAW9, J7HAX1, J7HAX8, J7HAY6_HUMAN, J7HAY6, J7H9Z3_HUMAN, J7H9Z3, J7H7C4_HUMAN, J7H7C4
Source gene ENSG00000255192
Alternative splicing NANP8_HUMAN, A0A0D9SG05_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

NANP8_HUMAN is shown as NANOGP8 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for NANOGP8

Protein NANP8_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05205Proteoglycans in cancer

KEGG orthologous groups

KONameDescription
K10164NANOGhomeobox protein Nanog
K09317EMXhomeobox protein EMX

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000487073 in eggNOG.

OGTaxonomic classDescription
LKOG0843All organisms (root)homeobox protein EMX,homeobox protein notochord,homeobox protein ventral anterior
KOG0843Eukaryota (superkingdom)homeobox protein EMX,homeobox protein notochord,homeobox protein ventral anterior
HTRIPMetazoa (kingdom)homeobox protein Nanog
94JJAChordata (phylum)homeobox protein Nanog
5QCW5Sarcopterygii (superclass)homeobox protein Nanog
8ZCDYMammalia (class)homeobox protein Nanog
4RBY9Euarchontoglires (superorder)homeobox protein Nanog
7KAP4Opisthokonta (clade)homeobox protein Nanog
9FYAFVertebrata (clade)homeobox protein Nanog
H4G7RBilateria (clade)homeobox protein Nanog

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: