Domains within Homo sapiens protein NASP_HUMAN (P49321)

Nuclear autoantigenic sperm protein

Alternative representations: 1 /

Protein length788 aa
Source databaseUniProt
Identifiers P49321, NASP_HUMAN, ENSP00000255120.5, ENSP00000255120, A8K6H2, B4DQP3, D3DQ07, F5H3J2, Q53GW5, Q5T622, Q5T625, Q96A69, Q9BTW2
Source gene ENSG00000132780
Alternative splicing ENSP00000400792.2, E9PAU3_HUMAN, E9PKR5_HUMAN, E9PQG5_HUMAN, E9PJQ2_HUMAN, ENSP00000437241.1, E9PPQ8_HUMAN, E9PRH9_HUMAN, NASP_HUMAN, E9PPR5_HUMAN, Q5T624_HUMAN, Q5T626_HUMAN, H0YF33_HUMAN, H0YDS9_HUMAN, P49321-4

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

NASP_HUMAN is shown as NASP in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for NASP

Protein NASP_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04212Longevity regulating pathway - worm

KEGG orthologous groups

KONameDescription
K11291NASPnuclear autoantigenic sperm protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000255120 in eggNOG.

OGTaxonomic classDescription
LKOG4563All organisms (root)nuclear autoantigenic sperm protein,HAT1-interacting factor 1,heat shock factor-binding protein 1
KOG4563Eukaryota (superkingdom)nuclear autoantigenic sperm protein,HAT1-interacting factor 1,heat shock factor-binding protein 1
HSQF9Metazoa (kingdom)nuclear autoantigenic sperm protein
944X5Chordata (phylum)nuclear autoantigenic sperm protein
5QQ0YSarcopterygii (superclass)nuclear autoantigenic sperm protein
8Z53YMammalia (class)nuclear autoantigenic sperm protein
4R9P3Euarchontoglires (superorder)nuclear autoantigenic sperm protein
4ZW0TPrimates (order)nuclear autoantigenic sperm protein
98F4FHaplorrhini (suborder)nuclear autoantigenic sperm protein
BV9ASSimiiformes (infraorder)nuclear autoantigenic sperm protein
9EH8FCatarrhini (parvorder)nuclear autoantigenic sperm protein
H525PBilateria (clade)nuclear autoantigenic sperm protein
9FTJZVertebrata (clade)nuclear autoantigenic sperm protein
7HJQXOpisthokonta (clade)nuclear autoantigenic sperm protein,HAT1-interacting factor 1,heat shock factor-binding protein 1
FX360Hominoidea (superfamily)nuclear autoantigenic sperm protein
5N8CHHominidae (family)nuclear autoantigenic sperm protein
5Y08GHomininae (subfamily)nuclear autoantigenic sperm protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: