Domains within Homo sapiens protein O75128-7

Isoform 7 of Protein cordon-bleu

Alternative representations: 1 /

Protein length1271 aa
Source databaseUniProt
Identifiers O75128-7, ENSP00000378912.3, ENSP00000378912
Source gene ENSG00000106078
Alternative splicing ENSP00000413498.1, H7C1N2_HUMAN, COBL_HUMAN, H7C2C4_HUMAN, O75128-4, O75128-5, A0A0J9YWK3_HUMAN, C9J9X1_HUMAN, O75128-7

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

O75128-7 is shown as COBL in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for COBL

Protein O75128-7 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K25874KIRREL, NEPHKirrel/Neph family protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000378912 in eggNOG.

OGTaxonomic classDescription
LKOG3510All organisms (root)Kirrel/Neph family protein,neural cell adhesion molecule,neurotrimin
KOG3510Eukaryota (superkingdom)Kirrel/Neph family protein,neural cell adhesion molecule,neurotrimin
HV0JBMetazoa (kingdom)protein cordon-bleu
94N0RChordata (phylum)protein cordon-bleu
5QG1XSarcopterygii (superclass)protein cordon-bleu
8Z0YWMammalia (class)protein cordon-bleu
4R60QEuarchontoglires (superorder)protein cordon-bleu
4ZRFVPrimates (order)protein cordon-bleu
98DZAHaplorrhini (suborder)protein cordon-bleu
BV706Simiiformes (infraorder)protein cordon-bleu
9F1ANCatarrhini (parvorder)protein cordon-bleu
9GTV1Vertebrata (clade)protein cordon-bleu
7HX6AOpisthokonta (clade)protein cordon-bleu
H6YK8Bilateria (clade)protein cordon-bleu
FX741Hominoidea (superfamily)protein cordon-bleu
5NAXSHominidae (family)Cobl,WH2
5XU3NHomininae (subfamily)Cobl,WH2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: