Domains within Homo sapiens protein P60201-2

Isoform DM-20 of Myelin proteolipid protein

Alternative representations: 1 /

Protein length242 aa
Source databaseUniProt
Identifiers P60201-2, ENSP00000477619.1, ENSP00000477619, K7ASA9_PANTR, K7ASA9, A0A0S2Z4D4_HUMAN, A0A0S2Z4D4, A0A2J8VAY5_PONAB, A0A2J8VAY5, M3X0A7_FELCA, M3X0A7, M3YDW4_MUSPF, M3YDW4, A0A097BVK2_RAT, A0A097BVK2, A0A286XSA9_CAVPO, A0A286XSA9, P60202-2, Q5R6E6-2
Source gene ENSG00000123560
Alternative splicing ENSP00000403335.1, ENSP00000480409.1, ENSP00000413931.1, ENSP00000393391.1, ENSP00000391853.1, MYPR_HUMAN, P60201-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

P60201-2 is shown as Plp1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Plp1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9669.ENSMPUP00000009521 in eggNOG.

OGTaxonomic classDescription
LKOG4800All organisms (root)myelin proteolipid protein
KOG4800Eukaryota (superkingdom)myelin proteolipid protein
HSY5UMetazoa (kingdom)myelin proteolipid protein
9420RChordata (phylum)myelin proteolipid protein
5QQB1Sarcopterygii (superclass)myelin proteolipid protein
8ZMVAMammalia (class)myelin proteolipid protein
BQUYULaurasiatheria (superorder)myelin proteolipid protein
AR7CGCarnivora (order)myelin proteolipid protein
HBSV8Caniformia (suborder)myelin proteolipid protein
9FMZWVertebrata (clade)myelin proteolipid protein
H54ITBilateria (clade)myelin proteolipid protein
7J1X9Opisthokonta (clade)myelin proteolipid protein
E0A8TMustelidae (family)myelin proteolipid protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: