Domains within Homo sapiens protein PANKY_HUMAN (Q7Z3H0)

Photoreceptor ankyrin repeat protein

Alternative representations: 1 /

Protein length452 aa
Source databaseUniProt
Identifiers PANKY_HUMAN, Q7Z3H0, ENSP00000301190.6, ENSP00000301190, Q0VAA7, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0, Q5K625_HUMAN, Q5K625, Q5K618_HUMAN, Q5K618, Q5K617_HUMAN, Q5K617, Q5K626_HUMAN, Q5K626
Source gene ENSG00000167612
Alternative splicing PANKY_HUMAN, F8VTQ6_HUMAN, ENSP00000344690.4

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

PANKY_HUMAN is shown as ANKRD33 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ANKRD33

Protein PANKY_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04390Hippo signaling pathway
map04530Tight junction

KEGG orthologous groups

KONameDescription
K24049MPP3_7MAGUK p55 subfamily member 3/7
K24048MPP2_6MAGUK p55 subfamily member 2/6
K00942gmk, GUK1guanylate kinase [EC:2.7.4.8] iPath3
Some of these orthologous groups are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000301190 in eggNOG.

OGTaxonomic classDescription
LCOG0194All organisms (root)guanylate kinase [EC:2.7.4.8],MAGUK p55 subfamily member 2/6,MAGUK p55 subfamily member 3/7
KOG0609Eukaryota (superkingdom)MAGUK p55 subfamily member 2/6,MAGUK p55 subfamily member 3/7,MAGUK p55 subfamily member 5
HUINRMetazoa (kingdom)MAGUK p55 subfamily member 5,MAGUK p55 subfamily member 3/7,dual specificity phosphatase 3 [EC:3.1.3.16 3.1.3.48]
94QDHChordata (phylum)Ank_2,Ank,Ank_4
5QBDSSarcopterygii (superclass)Ank_2,Ank,Ank_4
8Z9QYMammalia (class)Ank_2,Ank_4,Ank_5
4RNXNEuarchontoglires (superorder)Ank_2,Ank_4,Ank_5
4ZTPSPrimates (order)Ank_2,Ank_4
98ER8Haplorrhini (suborder)Ank_2,Ank_4
BV9Y0Simiiformes (infraorder)Ank_2,Ank_4
9F0DACatarrhini (parvorder)Ank_2
H4BV1Bilateria (clade)Ank_2,Ank,Ank_4
7GT74Opisthokonta (clade)MAGUK p55 subfamily member 3/7,MAGUK p55 subfamily member 5,dual specificity phosphatase 3 [EC:3.1.3.16 3.1.3.48]
9FWIRVertebrata (clade)Ank_2,Ank,Ank_4
FX2TVHominoidea (superfamily)Ank_2
5N3YFHominidae (family)Ank_2
5XWNFHomininae (subfamily)Ank_2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: