Domains within Mus musculus protein PCLO_MOUSE (Q9QYX7)

Protein piccolo

Alternative representations: 1 /

Protein length5068 aa
Source databaseUniProt
Identifiers PCLO_MOUSE, Q9QYX7, ENSMUSP00000030691.9, ENSMUSP00000030691, E9QK94, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
Source gene ENSMUSG00000061601
Alternative splicing Q9QYX7-2, PCLO_MOUSE, S4R2E0_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

PCLO_MOUSE is shown as Pclo in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pclo

Protein PCLO_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04911Insulin secretion

KEGG orthologous groups

KONameDescription
K07604KRT1type I keratin, acidic
K16882PCLOprotein piccolo

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000030691 in eggNOG.

OGTaxonomic classDescription
6YJQKAll organisms (root)type I keratin, acidic,endoglucanase [EC:3.2.1.4],type II keratin, basic
KOG0266Eukaryota (superkingdom)type I keratin, acidic,endoglucanase [EC:3.2.1.4],type II keratin, basic
HSN1SMetazoa (kingdom)protein piccolo
93RZFChordata (phylum)protein piccolo
5QKCJSarcopterygii (superclass)protein piccolo
H4WAPBilateria (clade)protein piccolo
7M8VROpisthokonta (clade)protein piccolo,mucin-6
9GPERVertebrata (clade)protein piccolo

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: