Domains within Homo sapiens protein POTB3_HUMAN (A0JP26)

POTE ankyrin domain family member B3

Alternative representations: 1 /

Protein length581 aa
Source databaseUniProt
Identifiers POTB3_HUMAN, A0JP26, ENSP00000483103.1, ENSP00000483103, A0A096LPD0, Q6NXN7, Q6S5H4, Q6S5H7
Source gene ENSG00000278522
Alternative splicing A0A0C4DH93_HUMAN, POTB3_HUMAN, A0JP26-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

POTB3_HUMAN is shown as POTEB3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for POTEB3

Protein POTB3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05132Salmonella infection

KEGG orthologous groups

KONameDescription
K10355ACTFactin, other eukaryote

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000483103 in eggNOG.

OGTaxonomic classDescription
LCOG5277All organisms (root)actin, other eukaryote,actin-related protein 3,actin-related protein 2
KOG0676Eukaryota (superkingdom)actin, other eukaryote,centractin,reversibly glycosylated polypeptide / UDP-arabinopyranose mutase [EC:2.4.1.- 5.4.99.30]
HW0P1Metazoa (kingdom)ankyrin repeat domain-containing protein 26,periphilin-1,POTE ankyrin domain family protein
93KSRChordata (phylum)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
5QZBASarcopterygii (superclass)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
8YZT7Mammalia (class)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
4R4CZEuarchontoglires (superorder)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
500UIPrimates (order)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
989TEHaplorrhini (suborder)POTE ankyrin domain family protein
BVC90Simiiformes (infraorder)POTE ankyrin domain family protein
H46IYBilateria (clade)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
9FSWDVertebrata (clade)ankyrin repeat domain-containing protein 26,POTE ankyrin domain family protein
7JFIWOpisthokonta (clade)ankyrin repeat domain-containing protein 26,periphilin-1,POTE ankyrin domain family protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: